1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Journal of Medicinal Chemistry

Volumn 38, Issue 22, 1995, Pages 4570-4578

  Li, James J ^a   Anderson, Gary D ^a   Burton, Earl G ^a   Cogburn, J Nita ^a   Collins, Joe T ^a   Garland, Danny J ^a   Gregory, Susan A ^a   Huang, Horng Chih ^a   Isakson, Peter C ^a   Koboldt, Carol M ^a   Logusch, Eugene W ^a   Norton, Monica B ^a   Perkins, William E ^a   Reinhard, Emily J ^a   Seibert, Karen ^a   Veenhuizen, Amy W ^a   Zhang, Yan ^a   Reitz, David B ^a  

^a MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (3 CHLORO 4 FLUOROPHENYL) 1 CYCLOPENTENYL]BENZENESULFONAMIDE; 5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; ANTIINFLAMMATORY AGENT; CYCLOPENTANE DERIVATIVE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ADJUVANT DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYTOTOXICITY; DOSE RESPONSE; DRUG ELIMINATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NEPHROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; RAT; RHEUMATOID ARTHRITIS;

ADMINISTRATION, ORAL; ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; CYCLOOXYGENASE INHIBITORS; CYCLOPENTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; INDOMETHACIN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MOLECULAR STRUCTURE; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; SULFONES;

EID: 0028889567     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00022a023     Document Type: Article

References (23)

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