Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction

Bioorganic and Medicinal Chemistry Letters

Volumn 5, Issue 3, 1995, Pages 283-288

  Labelle, M ^c   Belley, M ^a   Gareau, Y ^a   Gauthier, J Y ^a   Guay, D ^a   Gordon, R ^a   Grossman, S G ^b   Jones, T R ^a   Leblanc, Y ^a   McAuliffe, M ^a   McFarlane, C ^a   Masson, P ^a   Metters, K M ^a   Ouimet, N ^a   Patrick, D H ^b   Piechuta, H ^a   Rochette, C ^a   Sawyer, N ^a   Xiang, Y B ^a   Pickett, C B ^a   Ford Hutchinson, A W ^a   Zamboni, R J ^a   Young, R N ^a   more..

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOTRIENE D4 RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; UNCLASSIFIED DRUG; VERLUKAST; ZAFIRLUKAST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INDUCTION; FEMALE; GUINEA PIG; LIPID PEROXIDATION; LIVER WEIGHT; LUNG; MALE; MONKEY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PEROXISOME; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SMOOTH MUSCLE CONTRACTION; TRACHEA;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0028888059     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00023-M     Document Type: Article

References (27)

1. 677 The therapeutic effects of MK-571, a potent and selective leukotriene (LT) D receptor antagonist, in patients with chronic asthma