A Novel Serine/Threonine‐Specific Protein Phosphotransferase Activity of Nm23/Nucleoside‐Diphosphate Kinase

European Journal of Biochemistry

Volumn 234, Issue 1, 1995, Pages 200-207

  Engel, Matthias ^a   Véron, Michel ^b   Theisinger, Birgit ^a   Lacombe, Marie‐Lise ^c   Seib, Thomas ^a   Dooley, Steven ^a   Welter, Cornelius ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b INSTITUT PASTEUR   (France)

^c INSERM   (France)

Author keywords

Nm23; nucleoside diphosphate kinase; protein histidine kinase; serine phosphorylation

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE; PHOSPHOTRANSFERASE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; DROSOPHILA; ENZYME ACTIVITY; ERYTHROCYTE; HUMAN; HUMAN CELL; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCODINA; YEAST;

AMINO ACIDS; BINDING SITES; HUMAN; KINETICS; NUCLEOSIDE-DIPHOSPHATE KINASE; PHOSPHORYLATION; PHOSPHOTRANSFERASES; SERINE; THREONINE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; UREA;

EID: 0028887085     PISSN: 00142956     EISSN: 14321033     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1995.200_c.x     Document Type: Article

References (52)

1. Nucleoside diphosphokinases
2. Nucleoside diphosphate kinase from human erythrocytes: purification, molecular mass and subunit structure
3. Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme
4. Evidence for a novel gene associated with low tumor metastatic potential
5. Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis
6. Defining the critical gene expression changes associated with expres sion and suppression of the tumorigenic and metastatic phenotype in Ha‐ras‐transformed cloned rat embryo fibroblast cells
7. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23‐transtected melanoma cells
8. Transfection of human nm23‐Hl into the human MDA‐MB‐435 breast carcinoma cell line: effects on tumor metastatic potential, coloni zation and enzymic activity
9. Expression level of the nm23 gene in clonal populations of metastatic murine and human neoplasms
10. Increased expression of nucleoside diphosphate kinase/nm23 and c‐Ha‐ras mRNA is associated with spontaneous lung metastasis in rat‐transplantable osteosarcomas
11. Nm23/nucleoside diphosphate kinase: toward a structural and biochemical un derstanding of its biological functions
12. A Droxophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase
13. Developmental consequences of awdb3, a cell‐autonomous lethal mutation of Droxophila induced by hybrid dysgcnesis
14. Embryonic expression of nm23 during mouse organogenesis
15. Proliferation‐related expres sion of p19/nm23 nucleoside diphosphate kinase
16. Identity of a differentiation inhibiting factor for mouse myeloid leukemia cells with NM23/nucleoside diphosphate kinase
17. Dictyostelium nucleoside diphosphate kinase highly homologous to Nm23 and Awd proteins involved in mammalian tumor metastasis and Drosophila development
18. A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential
19. Nm23 and breast cancer metastasis
20. Nucleoside diphosphate kinases, nm23, and tumor metastasis: possible biochemical mechanisms
21. Nucleoside diphosphate kinases, nm23 and tumor metastasis: possible biochemical mechanisms
22. Human c‐myc transcription factor PuF identified as nm23‐H2 nu cleoside diphosphate kinase, a candidate suppressor of tumor me tastasis
23. Reduced nm 23‐H1 messenger RNA expression in metastatic lymph nodes from pa tients with papillary carcinoma of the thyroid
24. Reduced expression of nm23‐Hl, but not of nm23‐H2. is concordant with the frequency of lymph‐node metas tasis of human breast cancer
25. Signal transduction pathways involving protein phosphorylation in prokaryotes
26. Phosphorylation of nm23/nucleoside diphosphate kinase by casein kinase 2 in vitro
27. Equilibrium dissociation and unfolding of nucleoside diphosphate kinase from Dictyostelium discoideum. Role of proline 100 in the sta bility of the hexameric enzyme
28. Reduced Nm23/Awd protein in tumour metastasis and ab errant Drosophila development
29. X‐ray structure of nucleoside diphosphate kinase
30. Nucleoside diphosphate kinase: investigation of the active site and of the conformational stability by site‐directed mutagenesis
31. Isolation and characterization of recombinant human casein kinase II sub‐units alpha and beta from bacteria
32. Rapid large‐scale purification of pig heart nucleoside diphosphate kinase by affinity chromatography on Cibacron blue 3G‐A Sepharose
33. Thin‐layer chromatography can resolve phosphotyrosine, phosphoserine, and phosphothreonine in a protein hydrolyzate
34. A hepatic soluble cyclic nucleotide‐independent protein kinase
35. Crystal structure of the Awd nucleoside diphosphate kinase from Drosophila
36. Molecular species of a soluble nucleoside diphosphokinase related to the Na+, K + ‐ATPase
37. Contribution of subunit interactions to the effectiveness of catalysis by succinyl coenzyme A synthetase
38. Adenosine 5′‐diphosphate binding and the active site of nucleoside diphosphate kinase
39. Overexpression of nucleoside diphosphate kinase (Nm23) in solid tumours
40. High levels of nm23‐Hl and nm23‐H2 messenger RNA in human squamous‐cell lung carcinoma are as sociated with poor differentiation and advanced tumor stages
41. Isolation of a mRNA encoding a nucleoside diphosphate kinase from tomato that is up‐regulated by wounding
42. Autophosphorylation of plasma membrane bound calcium calmodulin dependent protein kinase from pea seedlings and modification of catalytic activity by autophosphorylation
43. 2+ ‐calmodulin regulated plasma membrane located protein kinase from pea
44. Characterization of a low molecular mass autophosphorylating protein in cultured sugarcane cells and its identification as a nu cleoside diphosphate kinase
45. Arabidopsis ethylene‐response gene ETR1: similarity of product to two‐component regulators
46. A yeast protein similar to bacterial two‐component regulators
47. A two‐component system that regulates an osmosensing MAP kinase cascade in yeast
48. Branched‐chain alpha‐ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases
49. A cromoglycate binding protein from rat mast cells of a leukemia line is a nucleoside diphosphate kinase
50. Inhibition of cell motility after nm23 transfection of human and murine tumor cells
51. k‐pn. a homologue of the metastasis suppressor gene nm23, suppresses the Tum‐I haematopoietic oncogene
52. The Role of nm23 in Transforming Growth Factor β1‐mediated Adherence and Growth Arrest