Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine

Psychopharmacology

Volumn 122, Issue 1, 1995, Pages 35-43

  Lipska, B K ^a   Weinberger, D R ^a   Swerdlow, N R ^b   Geyer, M A ^b   Braff, D L ^b   Jaskiw, G E ^c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Brecksville VAMC ^*  (United States)

Author keywords

Apomorphine; Hippocampus; Ibotenic acid; Neonatal lesion; Prepulse inhibition of startle; Sensorimotor gating; Startle

Indexed keywords

APOMORPHINE; EXCITOTOXIN; IBOTENIC ACID;

ACOUSTIC REFLEX; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; HIPPOCAMPUS; HISTOLOGY; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; NEWBORN; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; STARTLE REFLEX; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; ANIMALS, NEWBORN; APOMORPHINE; HIPPOCAMPUS; IBOTENIC ACID; MALE; PUBERTY; RATS; RATS, SPRAGUE-DAWLEY; STARTLE REACTION; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028886663     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/BF02246439     Document Type: Article

References (47)

1. Auditory sensory gating in hippocampal neurons: a model system in the rat
2. Sensorimotor gating and habituation evoked by electro-cutaneous stimulation in schizophrenia
3. Information processing and attention dysfunctions in schizophrenia
4. Prestimulus effects on human startle reflex in normals and schizophrenics
5. Gating and habituation of the startle reflex in schizophrenic patients
6. Impaired startle prepulse inhibition and habituation in schizotypal patients
7. Carbachol infusion into the dentate gyrus disrupts sensorimotor gating of startle in the rat
8. Twenty-four hour periodicity of the startle response in rats
9. Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats
10. Habituation of the blink reflex in normals and schzophrenic patients
11. Startle response models of sensorimotor gating and habituation deficits in schizophrenia
12. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia
13. The more or less startling effects of weak prestimuli
14. Startle gating deficits occur across prepulse intensities in schizophrenic patients
15. Smooth pursuit eye movements, attention and schizophrenia
16. Reflex modification in the domain of startle: II. The anomalous history of a robust and ubiquitous phenomenon
17. Dopamine and schizophrenia - a cortically corrective perspective
18. Failure of haloperidol to block the effects of phencyclidine and dizolcipine on prepulse inhibition of startle
19. Cortical regulation of the mesolimbic dopamine system: implications for schizophrenia
20. Delayed effects of neonatal hippocampal damage on haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat
21. Gonadectomy does not prevent novelty or drug-induced motor hyperresponsiveness in rats with neonatal hippocampal damage
22. Subchronic treatment with haloperidol and clozapine in rats with neonatal excitotoxic hippocampal damage
23. Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat
24. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia
25. The effects of combined prefrontal cortical and hippocampal damage on dopamine-related behaviors in rats
26. Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat
27. Dopaminergic stimulation disrupts sensorimotor gating in the rat
28. Disorders of attention and perception in early schizophrenia
29. Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains
30. Sensory gating in rats depleted of dopamine as neonates: potential relevance to findings in schizophrenic patients
31. Deficits in sensory gating in schizophrenic patients and their relatives: evidence obtained with auditory evoked responses
32. Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia
33. Prepulse inhibition of acoustic startle in rats after lesions of the pedunculopontine nucleus
34. Central dopamine hyperactivity in rats mimicks abnormal acoustic startle response in schizophrenics
35. Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine
36. Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusions into the nucleus accumbens
37. Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat
38. Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats
39. Neural substrates of sensorimotor gating of the startle reflex: preclinical findings and their implications
40. Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients
41. Implications of normal brain development for the pathogenesis of schizophrenia
42. Social isolation produces developmentally specific deficits in prepulse inhibition of the acoustic startle response but does not disrupt latent inhibition