Loss of Heterozygosity at the Familial RCC t(3;8) Locus in Most Clear Cell Renal Carcinomas

Cancer Research

Volumn 55, Issue 22, 1995, Pages 5348-5353

  Druck, Teresa ^a   Kastury, Kumar ^a   Ohta, Masataka ^a   LaForgia, Sal ^a   Huebner, Kay ^a   Lasota, Jerzy ^b   McCue, Peter ^b   Hadaczek, Piotr ^c   Podolski, Jacek ^c   Toloczko, Aleksandra ^c   Lubinski, Jan ^c   Sikorski, Andrzej ^c  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; BASE PAIRING; CARCINOGENESIS; CHROMOSOME LOSS; CHROMOSOME TRANSLOCATION 3; CHROMOSOME TRANSLOCATION 8; FAMILIAL CANCER; GENE EXPRESSION REGULATION; GENE LOCUS; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA, CLEAR CELL; AGED; AGED, 80 AND OVER; ALLELES; BASE SEQUENCE; CHROMOSOME DELETION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 8; FEMALE; HUMAN; KIDNEY NEOPLASMS; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; PROTEIN-TYROSINE-PHOSPHATASE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSLOCATION (GENETICS);

EID: 0028886532     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Cohen, A. J., Li, F. P., Berg, S., Marchetto, D. J., Tsai, S., Jacobs, S. C., and Brown, R. S. Hereditary renal-cell carcinoma associated with chromosomal translocation. N. Engl. J. Med., 301: 592–595, 1979.
2. Li, F. P., Decker, H. J., Zbar, B., Stanton, V. P., Jr., Kovacs, G., Seizinger, B. R., Aburatani, H., Sandberg, A. A., Berg, S., Hosoe, S., and Brown, R. S. Clinical and genetic studies of renal cell carcinomas in a family with a constitutional chromosome 3.8 translocation: genetics of familial renal carcinoma. Ann. Intern. Med., 118: 106–111, 1993.
3. Gnarra, J., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, R, Latif, F., Liu, S., Walther, M. M., Bander, N. H., Grossman, H. B., Brauch, H., Books, J. D., Isaac, W. B., Lerman, M. I., Zbar, B., and Linehan, W. M. VHL tumor suppressor gene mutations in renal carcinoma tumorigenesis. Nat. Genet., 7: 85–90, 1994.
4. Harris, P., Morton, G. G., Guglielmi, P., Li, F., Kelly, K., and Latt, S. A. Mapping by chromosome sorting of several gene probes, including c-myc, to the derivation chromosomes of a 3;8 translocation associated with familial renal cancer. Cytometry, 7: 589–594, 1986.
5. Gemmill, R. M., Coyle-Morris, J., Ware-Uribe, L., Pearson, N., Hecht, F., Brown, R. S., Li, F. P., and Drabkin, H. A. A 1.5-megabase restriction map surrounding MYC does not include the translocation breakpoint in familial renal cell carcinoma. Genomics, 4: 28–35, 1989.
6. LaForgia, S. K., Morse, B., Levy, J., Barnea, G., Li, F., Cannizzaro, L. A., Nowell, P. G., Glick, J., Boghosian-Sell, L. Weston, A., Harris, G. G., Drabkin, H., Patterson, D., Croce, G. M., Schlessinger, J., and Huebner, K. Receptor protein-tyrosine phosphatase y is a candidate tumor suppressor gene at human chromosome region 3p21. Proc. Natl. Acad. Sci. USA, 81: 5036–5040, 1991.
7. LaForgia, S., Lasota, J., Latif, F., Boghosian-Sell, L., Kastury, K., Ohta, M., Druck, T., Atchison, L., Cannizzaro, L., Barnea, G., Schlessinger, J., Modi, W., Kuzmin, I., Tory, K., Zbar, B., Croce, G. M., Lerman, M., and Huebner, K. Detailed genetic and physical map of the 3p chromosome region surrounding the familial RCC chromosome translocation, t(3;8)(pl4.2;q24.1). Cancer Res., 53: 3118–3124, 1993.
8. Boldog, F. L., Gemmill, R. M., Wilke, G. M., Glover, T. W., Nilsson, A. S., Chandrasekharappa, S. G., Brown, R. S., Li, F. P., and Drabkin, H. A. Positional cloning of the hereditary renal carcinoma 3;8 chromosome translocation breakpoint. Proc. Natl. Acad. Sci. USA, 90: 8509–8513, 1993.
9. Boldog, F. L., Waggoner, B., Glover, T. W., Chumakov, I., Paslier, D., Cohen, D., Gemmill, R. M., and Drabkin, H. A. Integrated YAC contig containing the 3pl4.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B. Genes Chromosomes & Cancer, 11: 216–221, 1994.
10. Michaelis, S. G., Bardenheuer, W., Lux, A., Schramm, A., Gockel, A., Siebert, R., Willers, G., Schmidtke, K., Todt, B., van der Hout, A. H., Buys, G. H. G. M., Heppell-Parton, A. G., Rabbitts, P. H., Ungar, S., Smith, D., Le Paslier, D., Cohen, D., Opalka, B., and Schutte, J. Characterization and chromosomal assignment of yeast artificial chromosomes containing human 3pl3-p21 -specific sequence tagged sites. Cancer Genet. Cytogenet., 81: 1–12, 1995.
11. Knudson, A. G. Antioncogenes and human cancer. Proc. Natl. Acad. Sci. USA, 90: 10914–10921, 1993.
12. Lubinski, J., Hadaczek, P., Podolski, J., Toloczko, A., Sikorski, A., McCue, P., Druck, T., and Huebner, K. Common regions of deletion in chromosome regions 3pl2 and 3pl4.2 in primary clear cell renal carcinomas. Cancer Res., 54: 3710–3713, 1994.
13. Naylor, S. L., Buys, G. H. G. M., and Carritt, B. Report of the fourth international workshop on human chromosome 3 mapping. Cytogenet. Cell Genet., 65:1–50,1994.
14. Roche, J., Whisenant, E., Boldog, F., Loeb, D., Vance, J. M., and Drabkin, H. Dinucleotide repeats flanking the renal cell carcinoma breakpoint at 3pl4.2. Hu. Mol. Genet., 3: 215, 1994.
15. Barnea, G., Silvennoinen, O., Shaanan, B., Honegger, A. M., Canoll, P. D., D'Eustachio, P., Morse, B., Levy, J. B., LaForgia, S., Huebner, K., Musacchio, J. M., Sap, J., and Schlessinger, J. Identification of a carbonic anhydrase-like domain in the extracellular region of RPTPg defines a new subfamily of receptor tyrosine phosphatases. Mol. Cell. Biol., 13: 1497–1506, 1993.
16. Bullrich, F., Druck, T., Kunapuli, P., Gomez, J., Gripp, K. W., Schlegelberger, B., Lasota, J., Aronson, M., Cannizzaro, L. A., Huebner, K., and Benovic, J. L. Chromosomal mapping of the human G protein-coupled receptor kinase GPRK5 and GPRK6 genes. Cytogenet. Cell Genet., 70: 250–254, 1995.
17. Kovacs, G., Emanuel, A., Neumann, H. P., and Kung, H. F. Cytogenetics of renal cell carcinomas associated with von Hippel-Lindau disease. Genes Chromosomes & Cancer, 3: 256–262, 1991.
18. Carroll, P. R., Murty, V. V. S., Reuter, V., Jhanwar, S., Fair, W. R., Whitmore, W. F.,and Chaganti, R. S. K. Abnormalities at chromosome region 3pl2–14 characterize clear cell renal carcinoma. Cancer Genet. Cytogenet., 26: 253–259, 1987.
19. Szucs, S., Muller-Brechlin, R., DeRiese, W., and Kovacs, G. Deletion 3p: the only chromosome loss in a primary renal cell carcinoma. Cancer Genet. Cytogenet., 26: 369–373, 1987.
20. Zbar, B., Brauch, H., Talmage, G., and Linehan, M. Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinomas. Nature (Lond.), 327: 721–724,1987.
21. Ogawa, O., Kakehi, Y., Ogawa, K., Koshiba, M., Sugiyama, T., and Yoshida, O. Allelic loss at chromosome 3p characterizes clear cell phenotype of renal cell carcinoma. Cancer Res., 51: 949–953, 1991.
22. Naylor, S. L., Johnson, B. E., Minna, J. D., and Sakaguchi, A. Y. Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer. Nature (Lond.), 329: 451–454, 1987.
23. Takagi, H., Nakamura, Y., and Takahasi, T. Three distinct regions involved in 3p deletion in human lung cancer. Oncogenes, 7: 445–459, 1992.
24. Kok, K., Osinga, J., Carritt, B., Davis, M. B., van der Hout, A. H., van der Veen, A. Y., Landsvater, R. M., de Leij, L. F. M. H., Bcrendsen, H. H., Postmus, P. E., Poppema, S., and Buys, G. H. G. M. Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature (Lond.), 330: 578–581, 1987.
25. Rabbitts, P., Douglas, J., Daly, M., Sundaresan, V., Fox, B., Haselton, P., Wells, F., Albertson, D., Waters, J., and Bergh, J. Frequency and extent of allelic loss in the short arm of chromosome 3 in non-small cell lung cancer. Genes Chromosomes & Cancer, 1: 95–105, 1989.
26. Yokota, J., Tsukada, Y., Nakajima, T., Gotoh, M., Shimosato, Y., Mori, N., Tsuano-kawa, Y., Sugimura, T., and Terada, M. Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix. Cancer Res., 49:3598–3601,1989.
27. Jones, M. H., and Nakamura, Y. Deletion mapping of chromosome 3p in female genital tract malignancies using microsatellite polymorphisms. Oncogene, 7: 1631–1634, 1992.
28. Maestro, R., Gasparotto, D., Vukosavljevic, T., Barzan, L., Sulfaro, S., and Boiocchi, M. Three discrete regions of deletion at 3p in head and neck cancers. Cancer Res., 53: 5775–5779, 1993.
29. Crossey, P. A., Maher, E. R., Jones, M. H., Richards, F. M., Latif, F., Phipps, M. E., Lush, M., Foster, K., Tory, K., Green, J. S., Oostra, B., Yakes, J. R. W., Linehan, W. M., Affara, N. A., Lerman, M., Zbar, B., Nakamura, Y., and Ferguson-Smieth, M. A. Genetic linkage between von Hippel-Lindau disease and three microsatellite polymorphisms refines the localization of the VHL locus. Hum. Mol. Genet., 2: 279–282, 1993.
30. Anglard, P., Tory, K., Brauch, H., Weiss, G. H., Latif, F., Merino, M. J., Lerman, M. I., Zbar, B., and Linehan, W. M. Molecular analysis of genetic changes in the origin and development of renal cell carcinoma. Cancer Res., 57: 1071–1077, 1991.
31. Yamakawa, K., Morita, R., Takahashi, E., Hori, T., Ishikawa, J., and Nakamura, Y. A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res., 51: 4707–4711, 1991.
32. Rabbitts, P., Berg, J., Douglas, J., Collins, F., and Waters, J. A submicroscropic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma. Genes Chromosomes &S Cancer, 2: 231–238, 1990.
33. Yamakawa, K., Takahashi, T., Horio, Y., Murata, Y., Takahashi, E., Hibi, K, Yokoyama, S., Ueda, R., Takahashi, T., and Nakamura, Y. Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22. Oncogene, 8: 327–330, 1993.
34. Daly, M. G., Xiang, R.-H., Buchhagen, D., Hensel, G. H., Garcia, D. K., Killary, A. M., Minna, J. D., and Naylor, S. L. A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity. Oncogene, 8: 1721–1729, 1993.
35. Kok, K., van den Berg, A., Veldhuis, P. M. J. F., van der Veen, A., Franke, M., Schoenmakers, E. F. P. M., Hulsbeek, M. M. R., van der Hout, A. H., de Leij, L., van de Ven, W., and Buys, G. H. G. M. A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes. Cancer Res., 54: 4183–4187, 1994.
36. Shuin, T., Kondo, K., Torigoe, S., Kishida, T., Kubota, Y., Hosaka, M., Nagashima, Y., Kitamura, H., Latif, F., Zbar, B., Lerman, M. I., and Yao, M. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res., 54: 2852–2855, 1994.
37. Foster, K., Prowse, A., van den Berg, A., Fleming, S., Hulsbeek, M. M. F., Crossey, P. A., Richards, F. M., Cairns, P., Affara, N. A., Ferguson-Smith, M. A., Buys, G. H. G. M., and Maher, E. R. Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma. Hum. Mol. Genet., 3: 2169–2173, 1994.
38. Fantes, J., Redeker, B., Breen, M., Boyle, S., Brown, J., Fletcher, J., Jones, S., Bickmore, W., Fukushima, Y., Mannens, M., Danes, S., Heyningen, V., and Hanson, I. Aniridia-associated cytogenetic rearrangements suggest that a position effect may cause the mutant phenotype. Hum. Mol. Genet., 4: 415–422, 1995.
39. Thoenes, W., Storkel, S. T., and Rumpelt, H. J. Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas): the basic cytological and histopathological elements and their use of diagnosis. Pathol. Res. Pract., 181: 125–143, 1986.
40. Robson, G. J., Churchill, B. M., and Anderson, W. The results of radical nephrectomy for renal cell carcinomas. J. Urol., 101: 297–301, 1969.