Possible links between glucose-induced changes in the energy state of pancreatic B cells and insulin release: Unmasking by decreasing a stable pool of adenine nucleotides in mouse islets

Journal of Clinical Investigation

Volumn 96, Issue 4, 1995, Pages 1738-1745

  Detimary, Philippe ^a   Jonas, Jean Christophe ^a   Henquin, Jean Claude ^a,b  

^a UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

ADP; ATP; Glucose metabolism; Pancreatic islets; Stimulus secretion coupling

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; FORSKOLIN; GLUCOSE; INSULIN; PHORBOL ESTER; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGRANULATION; ENERGY TRANSFER; FEMALE; GLUCOSE OXIDATION; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SECOND MESSENGER; STIMULUS SECRETION COUPLING;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMAL; CELL DEGRANULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MICE; ORGAN CULTURE; SUPPORT, NON-U.S. GOV'T;

EID: 0028885706     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118219     Document Type: Article

References (44)

1. Hedeskov, C. J. 1980. Mechanism of glucose-induced insulin secretion. Physiol. Rev. 60:442-509.
2. Meglasson, M. D., and F. M. Matschinsky. 1986. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab. Rev. 2:163-214.
3. MacDonald, M. J. 1990. Elusive proximal signals of β-cells for insulin secretion. Diabetes. 39:1461-1466.
4. Henquin, J. C. 1994. The cell biology of insulin secretion. In Joslin's Diabetes Mellitus, 13th edition. C. R. Kahn and G. C. Weir, editors. Lea & Febiger, Philadelphia. 56-80.
5. Ashcroft, F. M., and P. Rorsman. 1989. Electrophysiology of the pancreatic β-cell. Prog. Biophys. Mol. Biol. 54:87-143.
6. Rajan, A. S., L. Aguilar-Bryan, D. A. Nelson, G. C. Yaney, W. H. Hsu, D. L. Kunze, and A. E. Boyd. 1990. Ion channels and insulin secretion. Diabetes Care. 13:340-363.
7. Cook, D. L., and G. J. Taborsky. 1990. B-cell function and insulin secretion. In Diabetes Mellitus: Theory and Practice, 4th edition. H. Rifkin and D. Porte, editors. Elsevier Science Publishers B. V., Amsterdam. 89-103.
8. Dunne, M. J., and O. H. Petersen. 1991. Potassium selective ion channels in insulin-secreting cells: physiology, pharmacology and their role in stimulus-secretion coupling. Biochim. Biophys. Acta. 1071:67-82.
9. Misler, S., D. W. Barnett, K. D. Gillis, and D. M. Pressel. 1992. Electrophysiology of stimulus-secretion coupling in human β-cells. Diabetes. 41:1221-1228.
10. Hopkins, W. F., S. Fatherazi, B. Peter-Riesch, B. E. Corkey, and D. L. Cook. 1992. Two sites for adenine-nucleotide regulation of ATP-sensitive potassium channels in mouse pancreatic β-cells and HIT cells. J. Membrane Biol. 129:287-295.
11. Hellman, B., L.-A. Idahl, and A. Danielsson. 1969. Adenosine triphosphate levels of mammalian pancreatic β cells after stimulation with glucose and hypoglycemic sulfonylureas. Diabetes. 18:509-516.
12. Ashcroft, S. J. H., L. C. C. Weerasinghe, and P. J. Randle. 1973. Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. Biochem. J. 132:223-231.
13. Erecinska, M., J. Bryla, M. Michalik, M. D. Meglasson, and D. Nelson. 1992. Energy metabolism in islets of Langerhans. Biochim. Biophys. Acta. 1101:273-295.
14. Trus, M., H. Warner, and F. Matschinsky. 1980. Effects of glucose on insulin release and on intermediary metabolism of isolated perifused pancreatic islets from fed and fasted rats. Diabetes. 29:1-14.
15. Malaisse, W. J., and A. Sener. 1987. Glucose-induced changes in cytosolic ATP content in pancreatic islets. Biochim. Biophys. Acta. 927:190-195.
16. Warnotte, C., P. Gilon, M. Nenquin, and J. C. Henquin. 1994. Mechanisms of the stimulation of insulin release by saturated fatty acids: a study of palmitate effects in mouse β-cells. Diabetes. 43:703-711.
17. Ghosh, A., P. Ronner, E. Cheong, P. Khalid, and F. M. Matschinsky. 1991. The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet β-cells in the isolated perfused rat pancreas. J. Biol. Chem. 266:22887-22892.
18. Ohta, M., D. Nelson, J. Nelson, M. D. Meglasson, and M. Erecinska. 1990. Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans. J. Biol. Chem. 265:17525-17532.
19. 2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J. Biol. Chem. 266:9314-9319.
20. Zhou, X.-J., G. Z. Fadda, A. F. Perna, and S. G. Massry. 1991. Phosphate depletion impairs insulin secretion by pancreatic islets. Kidney Int. 39:120-128.
21. Detimary, P., P. Gilon, M. Nenquin, and J. C. Henquin. 1994. Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells. Biochem. J. 297:455-461.
22. Leitner, J. W., K. E. Sussman, A. E. Vatter, and F. H. Schneider. 1975. Adenine nucleotides in the secretory granule fraction of rat islets. Endocrinology. 95:662-677.
23. Hutton, J. C., E. J. Penn, and M. Peshavaria. 1983. Low-molecular-weight constituents of isolated insulin-secretory granules. Biochem. J. 210:297-305.
24. Lacy, P. E., and M. Kostianowsky. 1967. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes. 16:35-39.
25. Hampp, R. 1986. Luminometric method. In Methods of Enzymatic Analysis. H. U. Bergmeyer, editor. VCH Verlagsgesellschaft mbH, Weinheim, Germany. 370-379.
26. Palmer, M., R. Jursch, U. Weller, A. Valeva, K. Hilgert, M. Kehoe, and S. Bhakdi. 1993. Staphylococcus aureus α-toxin: production of functionally intact, site-specifically modifiable protein by introduction of cystein at positions 69, 130 and 186. J. Biol. Chem. 268:11959-11962.
27. 2+ and guanosine 5′-[γ-thio]triphosphate action on insulin secretion from α-toxin-permeabilized HIT-T15 cells. Biochem. J. 301:523-529.
28. Scott, D. A., and A. M. Fischer. 1938. The insulin and zinc content of normal and diabetic pancreas. J. Clin. Invest. 17:725-731.
29. Labarca, C., and K. Paigen. 1980. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102:344-352.
30. Henquin, J. C., and A. E. Lambert. 1976. Bicarbonate modulation of glucose-induced biphasic insulin release by rat islets. Am. J. Physiol. 231:713-721.
31. Stryer, L. 1988. Biochemistry. 3rd edition. W. H. Freeman and Co., San Francisco, 1089 pp.
32. 2-adrenoceptors modulating insulin release from isolated pancreatic islets. Naunyn-Schmiedebergs Arch. Pharmacol. 313:151-153.
33. + channel in mouse pancreatic beta-cells. Pflügers Arch. 47:493-499.
34. Ahnert-Hilger, G., W. Mach, K. J. Föhr, and M. Gratzl. 1989. Poration by α-toxin and streptolysin O: an approach to analyze intracellular processes. Methods Cell Biol. 31:63-90.
35. Grodsky, G. M., and J. L. Bolaffi. 1992. Desensitization of the insulin-secreting beta cell. J. Cell Biochem. 48:3-11.
36. Winkler, H., and E. Westhead. 1980. The molecular organization of adrenal chromaffin granules. Neuroscience. 5:1803-1823.
37. Corcoran, J. J., M. Korner, B. Caughey, and N. Kirshner. 1986. Metabolic pools of ATP in cultured bovine adrenal medullary chromaffin cells. J. Neurochem. 47:945-952.
38. Malaisse, W. J., J. C. Hutton, S. Kawazu, A. Herchuelz, I. Valverde, and A. Sener. 1979. The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events. Diabetologia. 16:331-341.
39. Andersson, A., and C. Hellerström. 1972. Metabolic characteristics of isolated pancreatic islets in tissue culture. Diabetes. 21:546-554.
40. Henquin, J. C. 1978. D-glucose inhibits potassium efflux from pancreatic islet cells. Nature (Lond.). 271:271-273.
41. Niki, I., F. M. Ashcroft, and S. J. H. Ashcroft. 1989. The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15-cells. FEBS Lett. 257:361-364.
42. + channels may control glucose-induced electrical activity in pancreatic B-cells. Biochem. Biophys. Res. Commun. 156:769-775.
43. 2+ channels by glucose metabolism in mouse pancreatic β-cells. Nature (Lond.). 342:550-553.
44. + channels in mouse B cells. J. Clin. Invest. 91:871-880.