Biodistribution of Monoclonal Antibodies: Scale-up from Mouse to Human Using a Physiologically Based Pharmacokinetic Model

Cancer Research

Volumn 55, Issue 20, 1995, Pages 4611-4622

  Baxter, Laurence T ^a   Zhu, Hui ^a,b   Jain, Rakesh K ^a   Mackensen, Daniel G ^c   Butler, William F ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Hybritech Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; HAPTEN; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BLOOD FLOW VELOCITY; BLOOD VESSEL PERMEABILITY; GENETIC ENGINEERING; HUMAN; HUMAN EXPERIMENT; MATHEMATICAL MODEL; MOUSE; NONHUMAN; ORGAN SIZE; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMAL; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; BODY WEIGHT; CARCINOEMBRYONIC ANTIGEN; CARCINOMA; COLORECTAL NEOPLASMS; HAPTENS; HUMAN; IMMUNOTHERAPY; MATHEMATICS; MICE; MODELS, BIOLOGICAL; SUPPORT, U.S. GOV'T, P.H.S.; TISSUE DISTRIBUTION;

EID: 0028885668     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

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