Altered expression of cyclins and c-fos in r6 cells that overproduce pkcε

Carcinogenesis

Volumn 16, Issue 10, 1995, Pages 2423-2428

  Han, Edward Kyu Ho ^a,b   Cacace, Angela M ^a,b   Sgambato, Alessandro ^a,b   Bernard Weinstein, I ^a,b  

^a Institute of Cancer Research   (United States)

^b College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; MESSENGER RNA; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; EARLY RESPONSE GENE; FIBROBLAST CULTURE; GENE EXPRESSION; MITOSIS INHIBITION; NONHUMAN; NORTHERN BLOTTING; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT;

ANIMAL; BLOTTING, NORTHERN; CELL CYCLE; CELL LINE; CULTURE MEDIA, SERUM-FREE; CYCLINS; DNA PROBES; FIBROBLASTS; FLOW CYTOMETRY; GENE EXPRESSION; GENES, FOS; ISOENZYMES; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TETRADECANOYLPHORBOL ACETATE;

EID: 0028883765     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/16.10.2423     Document Type: Article

References (47)

1. Nishizuka, Y. (1992) Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science, 258, 607-614
2. Hug, H. and Farre, T.F. (1993) Protein kinase C isozymes: Divergence in signal transduction. Biochem. J., 292, 329-343
3. Dekker, L.V. and Parker, P. (1994) Protein kinase C-a question of specificity. Trends Biochem. Sei., 19, 73-77
4. Borner, C., Filipuzz, J., Weinstein, I.B. and Imber, R. (1991) Failure of wild¬type or a mutant form of protein kinase C-a to transform fibroblasts. Nature, 353, 78-80
5. Housey, G.M., Johnson, M.D., Hsiao, W.L., O’Bnan, C.A., Murphy, J.P., Kirchmeier, P. and Weinstein, I.B. (1988) Oveiproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell, 52, 343-354
6. Cacace, A.M., Guadagno, S.N., Krauss, R.S., Fabbro, D. and Weinstein, I.B. (1993) The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene, 8, 2095-2104
7. Sherr, C.J. (1993) Mammalian G1 cyclins. Cell, 73, 1059-1065
8. Sherr, CJ. (1994) G1 phase progression: cycling on cue. Cell, 79, 551-555
9. Hunter, T. and Pines, J. (1994) Cyclins and cancer 2: cyclin D and CDK inhibitors come of age. Cell, 79, 573-582
10. Pardee, A.B. (1974) A restriction point for control of normal animal cell proliferation. Proc. Natl Acad. Sei. USA, 88, 1029-1043
11. Pardee, A.B. (1989) G1 events and regulation of cell proliferation. Science, 246, 603-608
12. Dulic, V., Lees, E. and Reed, S.l. (1992) Association of human cyclin E with a periodic Gl-S phase protein kinase. Science, 257, 1958-1961
13. Koff, A., Giordano, A., Desia, D. et al. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science, 257, 1689-1694
14. Lew, D.J., Dulic, V. and Reed, S.l. (1991) Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast. Cell, 66, 1197-1206
15. Matsushime, H., Roussel, M., Ashmun, R. and Sherr CJ. (1991) Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell, 65, 701-713
16. Motokura, T., Bloom, T., Kim, H.G., Juppner, H., Ruderman, J.V. and Kronenberg, H.M. (1991) A novel cyclin encoded by a bcl-hnked candidate oncogene. Nature, 350, 512-515
17. El-Deiry, W.S., Harper, J.W., O’Connor, P.M. et al. (1994) WAF/CIPl is induced in p53-mediated G1 arrest and apoptosis. Cancer Res., 54, 1169-1174
18. Gu, Y., Turck, C.W. and Morgan, D.O. (1993) Inhibition of CDK2 activity in vivo by an associated 20 K regulatory subunit Nature, 366, 707-710
19. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. (1993) The p21 Cdk-interacting protein Ctpl is a potent inhibitor of G1 cyclin-dependent kinases. Cell IS, 805-816
20. Xiong, Y, Hannon, G J., Zhang, H., Casso, D., Kobayashi, R. (1993) p21 is a universal inhibitor of cyclin kinases. Nature, 366, 701-704
21. Noda, A., Nig, Y., Venable, S.F., Pereira-Smith, O.M. and Smith, J.R. (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res., 211, 90-98
22. Polyak, K., Lee, M.-H., Erdjument-Bromage, H., Koff, A., Roberts, J.M., Tempst, P. and Massague, J. (1994) Cloning of p27klpl, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 78, 59-66
23. Toyoshima, H. (1994) p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell, 78, 67-74
24. Serrano, M., Hannon J. and Beach, D. (1993) A new regulatory motif in cell cycle control causing specific inhibitions of cyclin D/CDK. Nature, 366, 704-706
25. Kamb, A., Gruis, N.A., Weaver-Feldhaus, J. el al. (1994) A cell regulator potentially involved in oncogenesis of many tumor types. Science, 264, 463-440
26. Kosaka, C., Sasaguri, T., Masuda, J., Zen, K., Shimokado, K., Yokota, T. and Ogata, J. (1993) Protein kinase C-mediated inhibition of cyclin A expression in human vascular endothelial cells. Biochem. Biophys. Res. Commun., 193, 991-998
27. Won, K., Xiong, Y, Beach, D. and Gilman, M.Z. (1992) Growth regulated expression of D-type cyclin genes in human diploid fibroblasts. Proc. Natl Acad. Sei. USA, 89, 9910-9914
28. Sewing, A., Burger, C., Brusselbach, S., Schalk, C., Lucibello, F.C. and Muller, R (1993) Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J. Cell. Sei., 104, 545-554
29. Winston J.T. and Pledger, WJ. (1993) Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and independent mechanism. Mol. Biol. Cell., 4, 1133-1144
30. Lau, L.F. and Nathans, D. (1987) Expression of a set of growth-related immediate early genes in BALB/c3T3 cells: coordinate regulation with c¬fos or c-myc. Proc. Natl Acad. Sei. USA, 84, 1182-1186
31. Borner, C., Ueffing, M., Jaken S, Parker, PJ. and Weinstein, I.B. (1995) Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. J. Biol. Chem., 270, 78-86
32. Mischak, H., Goodnight, J., Kolch, W., Martiny-Baron, G., Schaechtle, C., (1993) Overexpression of protein kinase C-8 and -e in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigemcity. J. Biol. Chem., 268, 6090-6096
33. Medrano, E.E. and Pardee, A. (1980) Prevalent deficiency in tumor cells of cycloheximide-induced cycle arrest. Proc. Natl Acad. Sei. USA, 77, 4123-4126
34. Keyomarsi, K., Sandival, L., Band, V. and Pardee A. (1991) Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res., 51, 3602-3609
35. Quelle, D.E, Ashmun, R.A., Shurtleff, S.A., Kato, J.-Y., Bar-Sagi, D., Roussel, M.F. and (1993) Overexpression of mouse Dl-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev., 7, 1559-1571
36. Sewing, A. (1994) Protein kinase A phosphorylâtes cyclin D1 at three distinct sites within the cyclin box and at the C-terminus. Oncogene, 9, 2733-2736
37. Buchou, T., Kranenburg, O., van Dam, H., Roelen, D., Zantema, A., Hall, F.L. and van der Eb, A. (1993) Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1 A-transformed rodent cell lines. Oncogene, 8, 1765-1773
38. Jansen-Durr, P., Meichle, A., Steiner, P., Pagano, M., Finke, K., Botz, J., Wessbecher, J., Draetta, D. and Eilers, M. (1993) Differential modulation of cyclin gene expression by MYC. Proc. Natl Acad. Sei. USA, 90, 3685-3689
39. Philipp, A., Schneider, A., Vasrik, I., Finke, K., (1994) Repression of cyclin Dl: A novel function of MYC. Mol. Cell. Biol., 14, 4032-1043
40. Herber, B., Truss, M., Beato, M. and Muller, R. (1994) Inducible regulatory elements in the human cyclin Dl promoter. Oncogene, 9, 1295-1304
41. Dowdy, S.F., Hinds, P.W., Louie, K., Reed, S.l., Arnold, A. and Weinberg, R.A. (1993) Physical interaction of the retinoblastoma protein with human cyclin Dl. Cell, 73, 499-511
42. Hinds, P.W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S.l. and Weinberg, R.A. (1992) Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell, 70, 993-1006
43. Kato, J., Matsushime, H., Hiebert, S.W., Ewen, M.E. and Sherr CJ. (1993) Direct binding of cyclin D to the retinoblastoma product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev., 7, 331-342
44. Shigeoka, H. and Yang, H.C. (1990) c-fos Regulation in untransformed as compared to transformed Balh/c3T3 fibroblasts. Oncogene, 5, 741-745
45. Abate, C. and Curran, T. (1990) Encounters with Fos and Jun on the road to AP-1. Sem. Cancer Biol., 1, 19-26
46. Forrest, D. and Curran, T. (1992) Crossed signals: oncogenic transcription factors. Curr. Opin. Genetics Dev., 2, 19-27
47. Abate, C., Marshak, D.R. and Curran, T. (1991) Fos is phosphorylated by p34cdc2, cAMP-dependent protein kinase and protein kinase C at multiple sites clustered within regulatory regions. Oncogene, 6, 2179-2185