Production of fully human antibodies by transgenic mice

Current Opinion in Biotechnology

Volumn 6, Issue 5, 1995, Pages 561-566

  Jakobovits, Aya ^a  

^a CELL GENESYS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; BIOTECHNOLOGY; GENE TARGETING; GENETIC ENGINEERING; HUMAN; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

ANIMAL; ANTIBODIES, MONOCLONAL; GENES, IMMUNOGLOBULIN; HUMAN; MICE; MICE, TRANSGENIC;

EID: 0028883531     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/0958-1669(95)80093-X     Document Type: Article

References (24)

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10. The human immunoglobulin κ locus consists of two copies that are organized in opposite polarity
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17. Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production
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19. The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci
20. A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins
21. Antigen-specific human antibodies from mice comprising four distinct genetic modifications
22. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes
23. Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM
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