Activation of cultured vascular endothelial cells by antiphospholipid antibodies

Journal of Clinical Investigation

Volumn 96, Issue 5, 1995, Pages 2211-2219

  Simantov, Ronit ^a   LaSala, Johanna M ^a   Lo, Siu K ^a   Gharavi, Azzudin E ^b,c   Sammaritano, Lisa R ^b   Salmon, Jane E ^b   Silverstein, Roy L ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

adhesion; anticardiolipin; lupus; monocytes; thrombosis

Indexed keywords

CARDIOLIPIN; CARDIOLIPIN ANTIBODY; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FC RECEPTOR; IMMUNOGLOBULIN G; INTERCELLULAR ADHESION MOLECULE 1; PHOSPHOLIPID ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN ANTIBODY COMPLEX; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CELL ADHESION; CELL STIMULATION; CONTROLLED STUDY; FETUS WASTAGE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; THROMBOSIS; VASCULAR ENDOTHELIUM;

EID: 0028883356     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118276     Document Type: Article

References (32)

1. Sammaritano, L. R., A. E. Gharavi, and M. D. Lockshin. 1990. Antiphospholipid antibody syndrome: immunologic and clinical aspects. Semin. Arthritis Rheum. 20:81-96.
2. Harris, E. N., A. E. Gharavi, and G. R. V. Hughes. 1985. Antiphospholipid antibodies. Clin. Rheum. Dis. 11:591-609.
3. Lozier, J., N. Takahashi, and F. W. Putnam. 1984. Complete amino acid sequence of human plasma Beta-2-glycoprotein I. Proc. Natl. Acad. Sci. USA. 81:3640-3644.
4. McNeil, H. P., R. J. Simpson, C. N. Chesterman, and S. A. Krilis. 1990. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta-2-glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. USA. 87:4120-4124.
5. Love, P. E., and S. A. Santoro. 1990. Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders: Prevalence and clinical significance. Ann. Int. Med. 112:682-698.
6. Ginsburg, K. S., M. H. Liang, L. Newcomer, S. Z. Goldhaber, P. H. Schur, C. H. Hennekens, and M. J. Stampfer. 1992. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. Ann. Int. Med. 117:997-1002.
7. Gharavi, A. E., R. C. Mellors, and K. B. Elkon. 1989. IgG anti-cardiolipin antibodies in murine lupus. Clin. Exp. Immunol. 78:233-238.
8. Branch, D. W., D. J. Dudley, M. D. Mitchell, K. A. Creighton, T. M. Abbott, E. H. Hammond, and R. A. Daynes. 1990. Immunoglobulin G fractions from patients with aPL antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss. Am. J. Obstet. Gynecol. 163:210-216.
9. Cariou, R., G. Toblem, S. Bellucci, J. Soria, C. Soria, J. Maclouf, and J. Caen. 1988. Effect of lupus anticoagulant on antithrombogenic properties of endothelial cells-inhibition of thrombomodulin-dependent protein C activation. Thromb. Haemostasis. 60:54-58.
10. Smirnov, M. D., D. T. Triplett, P. C. Comp, N. L. Esmon, and C. T. Esmon. 1995. On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies. J. Clin. Invest. 95:309-316.
11. Shih, W., B. H. Chong, and L. N. Chesterman. 1993. Beta-2-glycoprotein 1 is a requirement for anticardiolipin antibody to activated platelets: differences with lupus anticoagulants. Blood. 81:1255-1262.
12. Lindsey, N. J., R. A. Dawson, F. I. Henderson, M. Greaves, and P. Hughes. Stimulation of von Willebrand factor antigen release by immunoglobulin from thrombosis prone patients with systemic lupus erythematosus and the anti-phospholipid syndrome. 1993. Br. J. Rheum. 32:123-126.
13. Cines, D. B., A. P. Lyss, M. Reeber, M. Bina, and R. J. DeHoratius. 1984. Presence of complement-fixing anti-endothelial cell antibodies in systemic lupus erythematosus. J Clin. Invest. 73:611-625.
14. Del Papa, N., P. L. Meroni, A. Tincani, E. N. Harris, S. S. Pierangeli, W. Barcellini, M. O. Borghi, G. Balestrieri, and C. Zanussi. 1992. Relationship between anti-phospholipid and anti-endothelial cell antibodies: further characterization of the reactivity on resting and cytokine-activated endothelial cells. Clin. Exp. Rheum. 10:37-42.
15. McCrae, K. R., A. DeMichele, P. Samuels, D. Roth, A. Kuo, Q.-H. Meng, J. Rauch, and D. Cines D. 1991. Detection of endothelial cell-reactive immunoglobulin in patients with anti-phospholipid antibodies. Br. J. Haematol. 79:595-605.
16. Hess, D. C., J. C. Shepard and R. J. Adams. 1993. Increased immunoglobulin binding to cerebral endothelium in patients with antiphospholipid antibodies. Stroke. 24:994-999.
17. 2-glycoprotein I in the rat: isolation from serum and demonstration in lipoprotein density fractions. Int. J. Biochem. 11:265-270.
18. Sammaritano, L. R., M. A. Lockshin, and A. E. Gharavi. 1992. Antiphospholipid antibodies differ in aPL cofactor requirement. Lupus. 1:83-90.
19. Ishizaka, K., and T. Ishizaka. 1960. Biological activity of aggregated gamma-globulin II. A study of various methods for aggregation and species differences. J. Immunol. 85:163-166,
20. Jaffe, E. A., R. L. Nachman, C. G. Becker, and C. R. Minick. 1973. Culture of human endothelial cells derived from umbilical cord veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52:2745-2756.
21. Ziegler-Heitbrock, H. W., E. Thiel, A. Futterer, V. Herzog, A. Wirtz, and G. Riethmuller. 1988. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int. J. Cancer. 41:456-461.
22. Tan, E. M., A. S. Cohen, J. F. Fries, A. T. Masi, D. J. McShane, N. F. Rothfield, J. C. Schaller, N. Talal, and P. J. Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis & Rheum. 25:1271-1277.
23. Gharavi, A. E., E. N. Harris, R. A. Asherson, and G. R. V. Hughes. 1987. Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Am. Rheum. Dis. 46:1-6.
24. Sammaritano, L. R., A. E. Gharavi, C. Soberano, R. A. Levy, and M. D. Lockshin. 1992. Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein. J. Clin. Immun. 12:27-35.
25. 2-glycoprotein I (apolipoprotein H). J. Clin. Invest. 90:1105-1109.
26. Rosenbaum, J., B. E. Pottinger, P. Woo, C. M. Black, S. Loizou, M. A. Byron, and J. D. Pearson. 1988. Measurement and characterization of circulating anti-endothelial cell IgG in connective tissue diseases. Clin. Exp. Immunol. 72:450-456.
27. Lo, S. K., A. Cheung, Q. Zheng, and R. L. Silverstein. 1995. Induction of tissue factor on monocytes by adhesion to endothelial cells. J. Immunol. 154:4768-4777.
28. Thornhill, M., S. M. Wellicome, D. L. Mahiouz, J. S. S. Lanchbury, U. Kyang-Aung and D. O. Haskard. 1991. TNF combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells: the contribution of vascular cell adhesion molecule-1-dependent and independent mechanisms. J. Immunol. 146:592-598.
29. Nachman, R. L., and R. L. Silverstein. 1993. Hypercoagulable states. Ann. Intern. Med. 119:819-827.
30. Bevilacqua, M. P., J. S. Pober, M. E. Wheeler, R. S. Cotran, and M. A. Gimbrone, Jr. 1985. Interleukin-1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, rnonocytes, and related leukocyte cell lines. J. Clin. Invest. 76:2003-2011.
31. Del Papa, N., G. Conforti, D. Gambini, W. Barcellini, M. O. Borghi, C. Fain, A. Tincani, G. Balestrieri, F. Tedesco, and P. L. Meroni. 1993. Characterization of anti-endothelial cell antibodies in antiphospholipid syndrome. In Molecular Basis of Human Diseases. E. E. Polli, editor. Elsevier Science Publishers, Amsterdam. 67-73.
32. Kornberg, A., M. Blank, S. Kaufman, and Y. Schoenfeld. 1994. Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J. Immunol. 153:1328-1332.