The Rb2/p130 gene product is a nuclear protein whose phosphorylation is cycle regulated

Journal of Cellular Biochemistry

Volumn 59, Issue 3, 1995, Pages 402-408

  Baldi, Alfonso ^a   De Luca, Antonio ^a   Claudio, Pier Paolo ^a   Baldi, Feliciano ^b   Giordano, Giovan Giacomo ^b   Tommasino, Massimo ^c   Paggi, Marco Giorgio ^d   Giordano, Antonio ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d NONE

Author keywords

cell cycle; E1A oncoprotein; nuclear phosphoprotein; pocket protein; Rb2 p130; retinoblastoma gene; tumor suppressor gene

Indexed keywords

GENE PRODUCT; ONCOPROTEIN; PHOSPHATASE; PHOSPHOPROTEIN; PHOSPHOTRANSFERASE; POLYCLONAL ANTIBODY; RETINOBLASTOMA PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

ANTIBODIES, MONOCLONAL; CELL CYCLE; COMPARATIVE STUDY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOSORBENT TECHNIQUES; MUTATION; NUCLEAR PROTEINS; OSTEOSARCOMA; PHOSPHOPROTEINS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; S PHASE; SEQUENCE HOMOLOGY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0028881866     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.240590311     Document Type: Article

References (40)

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2. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
3. The E2f transcription factor is a cellular target for the RB protein
4. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
5. pRb2/p130 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107
6. Cell cycle–specific association of E2F with the p130 E1A‐binding protein
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8. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptiblility gene
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14. Solubilization and purification of enzymatically active glutathione S‐transferase (pGEX) fusion proteins
15. A 60 kD cdc2‐associated polypeptide complexes with the E1A proteins in adenovirus‐infected cells
16. Cell cycle regulation of histone H1 kinase activity associated with adenovirus protein E1A
17. Human cyclin‐A and the retinoblastoma protein interact with similar but distinguishable sequences in the adenovirus E1A gene product
18. Characteristics of a human cell line transformed by DNA from human adenovirus type 5
19. Monoclonal antibodies specific for adenovirus early region 1A proteins: Extensive heterogeneity in early region 1A products
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27. Defective human retinoblastoma protein idenitified by lack of interatction with the E1A oncoprotein
28. Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding
29. Identification of a growth suppressive domain within the retinoblastoma gene product
30. The roles of tumor suppressors pRb and p53 in cell proliferation and cancer
31. E2F4 and E2F5, two members of the E2F family, are expressed in the early phases of the cell cycle
32. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response
33. C‐terminal truncation of the retinoblastoma gene product leads to functional inactivation
34. The transcription factor E2F interacts with the retinoblastoma product and a p107‐cyclin A complex in a cell cycle–regulated manner
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37. The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cell
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