The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription

Nature Genetics

Volumn 9, Issue 3, 1995, Pages 293-298

  Kennedy, Giulia Catignani ^a,c   German, Michael S ^b   Rutter, William J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SATELLITE DNA; TRANSCRIPTION FACTOR;

ARTICLE; GENE EXPRESSION REGULATION; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; TANDEM REPEAT; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 11; DIABETES MELLITUS, INSULIN-DEPENDENT; DNA, SATELLITE; HUMAN; INSULIN; ISLETS OF LANGERHANS; LINKAGE (GENETICS); MINISATELLITE REPEATS; MOLECULAR SEQUENCE DATA; POLYMORPHISM (GENETICS); PROMOTER REGIONS (GENETICS); SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0028881617     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng0395-293     Document Type: Article

References (27)

1. DeFranzo, R.A., Lecture 1987: The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM. Diabetes 37, 667-687 (1988).
2. Cherrington, A.D. et al. Insulin, glucagon and glucose as regulators of hepatic glucose uptake and production In vivo. Diabetes Met. Rev. 3, 307-332 (1987).
3. Froguel, P. et al. Familial hyperglycaemia due to mutations in glucokinase: definition of a subtype of diabetes mellitus. New Engl. J. Med. 328, 697-702 (1993).
4. Froguel, P. et al. The glucokinase locus on chromosome 7 is closely linked to early-onset non-insulin-dependent diabetes mellitus. Nature 356, 162-164 (1992).
5. Steiner, D.F. et al. Lessons learned from molecular biology of insulin-gene mutations. Diabetes Care 13, 600-609 (1990).
6. Van den Ouweland, J.M.W. et al. Mutation in mitochondrial tRNALeu (UUR) gene In a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nature Genet. 1, 368-371 (1993).
7. Taylor, S.I. Lessons from patients with mutations in the insulin-receptor gene. Diabetes 41, 1473-1490 (1992).
8. Levebre, P., Paolisso, G. & Scheen, A. The role of glucagon in non-insulin-dependent (type 2) diabetes mellitus. In New directions In research and clinical works for obesity and diabetes mellitus: (eds Sakamoto, N., Angel, A. & Hotta, N.) 25-29 (Elsevier Science Publishers B.V., 1991).
9. Baron, A.D., Schaeffer, L., Shragg, P. & Koltermann, G.O. role of hyperglucagonemla in maintenance of increased rates of hepatic glucose output in Type II diabetics. Diabetes 36, 274-283 (1987).
10. Segre, G.V. & Goldring, S.R. Receptors for secretln, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family.TEM 4, 309-314 (1993).
11. Jellnek, L.J. et al. Expression Cloning and Signaling Properties of the Rat Glucagon Receptor. Science 259, 1614-1616 (1993).
12. Lok, S. et al. The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization. Gene 140, 203-209 (1994).
13. Vionnet, N. et al. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature (356, 721-22 (1992).
14. Bell, G.I. et al. Gene for non-insulin dependent diabetes mellitus (maturity onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc. natn. Acad. Sci. U.S.A 88, 1484-1488 (1991).
15. Spielman, R.S., McGinnls, R.E. & Ewens, W.J. Transmission Test for Linkage Disequilibrium: The Insulin Gene Region and Insulin-dependent Diabetes Mellitus (IDDM). Am. J. hum. Genet. 52, 506-516 (1993).
16. Juller, C. et al. Insulin-IGF 2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature 354, 155-159 (1991).
17. Parsian, A. et al. Alcoholism and alleles of the human D2 dopamine receptor locus. Arch. Gen. Psychiatry 48, 655-663 (1991).
18. Spiegel, A.M., Weinstein, L.S. & Shenker, A. Abnormalities in G Protein-coupled Signal Transduction Pathways In Human Disease. J. clln. Inv. 92, 1119-1125 (1993).
19. Van Eyll, B., Lankat-Buttgerelt, B., Bode, H.P., Göke, R. & Göke, B. Cloning and functional expression of the GLP-1-Receptor from a human Insulinoma. Diabetes 43, (Suppl. 1) 178A (1994).
20. Van Schravendijk, C.F.H. et al. Pancreatic hormone receptors on islet cells. Endocrinology 117, 841-848 (1985).
21. Samols, E., Marrl, G. & Marks, V. Promotion of insulin secretion by glucagon. Lancet 2, 415-416 (1965).
22. Gallus, G. & Garancinl, P. Dati epidemlologlci sul diabete mellito in Italia.Epldemiol. e Prevenz. 48-49, 55-58 (1991).
23. Linger, R.H., Aguilar-Parada, E., Mueller, W.A. & Eisentrant, A.M. Studies of pancreatic α-cell function in normal and diabetic subjects. J. clln. Invest. 49, 837-845 (1970).
24. Raskin, P. & Unger, H. Hyperglucagonemia and its supression, importance in the metabolic control of diabetes. New Engl. J. Med. 290, 433-436 (1978).
25. Vionnet, N., Passa, P. & Froguel, P. Prevalence of mitochondrial gene mutations in families with diabetes mellitus. Lancet 342, 1429-1430 (1993).
26. Elston, R.C., Bailey-Wilson, J.E., Bonney, G.E., Keats, B.J. & Wilson, A.F. S.A.G.E. - A package of computer programs to perform statistical analysis in genetic epidemiology. Presented at the 7th international congress of human genetics, Berlin, Germany, September 22-26 (1986).
27. Ho, S.N., Hunt, H.D., Horton, R.M., Pullen, J.K. & Pease, L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59 (1989).