Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

British Journal of Cancer

Volumn 72, Issue 5, 1995, Pages 1189-1193

  Bates, P ^a   Fisher, R ^a   Ward, A ^a   Richardson, L ^a   Hill, D J ^b   Graham, C F ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Breast cancer; Insulin lke growth factor II; Mammary tumours; Transgcne

Indexed keywords

BETA LACTOGLOBULIN; MESSENGER RNA; SOMATOMEDIN B;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST ADENOCARCINOMA; BREAST CARCINOGENESIS; CANCER TRANSPLANTATION; CONTROLLED STUDY; FEMALE; GENE TRANSFER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOMBINANT GENE; REGULATOR GENE; SHEEP; TRANSGENIC MOUSE; ZYGOTE;

ADENOCARCINOMA; ANIMAL; CELL TRANSFORMATION, NEOPLASTIC; COMPARATIVE STUDY; CROSSES, GENETIC; FEMALE; GENE EXPRESSION REGULATION; INSULIN-LIKE GROWTH FACTOR II; LACTOGLOBULINS; MALE; MAMMAE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; NEOPLASM PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; SHEEP; SUPPORT, NON-U.S. GOV'T; TRANSGENES;

EID: 0028880017     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1995.484     Document Type: Article

References (48)

1. ALI S and CLARK AJ. (1988). Characterisation of the gene encoding ovine beta-lactoglobulin: similarity to the genes for the retinol binding proteins. J, Mol. Biol., 199, 415–426.
2. ALLEN ND, BARTON SC, SURANI MAH and REIK W. (1987). Production of transgenic mice. In Mammalian Development, a Practical Approach, Monk M. (ed.) pp. 217-234. IRL Press: Oxford.
3. BAKER J, LIU J-P, ROBERTSON EJ and EFSTRATLADIS A. (1993). Role of insulin-like growth factors in embryonic and postnatal growth. Cell, 75, 73–82.
4. BERNS EMJJ, KLUN JGM, VAN STAVERTEN IL, PORTENGEN H and FOEKENS JA. (1992). Sporadic amplification of the insulinlike growth factor I receptor gene in human breast tumours. Cancer Res., 52, 1036–1039.
5. BIDDLE C, LI CH, SCHOFIELD PN, TATE VE, HOPKINS B, ENGSTROM W, HUSKISSON N and GRAHAM CF (1988). InsuHn-hke growth factors and the multiplication of Tera-2, a human teratoma-derived cell line. J, Cell Sci., 99, 475–484.
6. BREIER BH, MILSOM SR, BLUM WF, SCHWANDER J, GALLAHER BW and GLUCKMAN PD. (1993). Insulin-like growth factors and their binding proteins in plasma and milk after growth hormone-stimulated galactopoiesis in normally lactating woman. Acta Endocrinol., 129, 427–435.
7. BRUNNER N, MOSER C, CLARKE R and CULLEN K. (1992). IGF-I and IGF-II expression in human breast cancer xenografts: relationship to hormone independence. Breast Cancer Res. Treat., 22, 39–45.
8. CALLAHAN R and SALOMON DS. (1993). Oncogenes, tumour suppressor genes and growth factors in breast cancer novel targets for diagnosis, prognosis and therapy. In Breast Cancer, Fentiman IS and Taylor-Papadimitriou J. (eds.) pp. 35-56. Cokl Spring Harbor Laboratory Press: Cold Spring Harbor, New York.
9. CHRISTOFORI G, NAIK P and HANAHAN D. (1994). A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature, 369, 414–417.
10. CHRISTOFORI G and HANAHAN D. (1994). Molecular dissection of multi-stage tumorigenesis in transgenic mice. Seminars in Cancer Biology, 5, 3–12.
11. CONOVER CA, KIEFER MC and ZAPF J. (1993). Post-translational regulation of insulin-like growth factor protein-4 in normal and transformed human fibroblasts. J. Clin. Invest., 91, 1129–1137.
12. CONOVER CA, CLARKSON JT and BALE LK. (1994). Insulin-like growth factor-II enhancement of human fibroblast growth via a non-receptor mediated mechanism. Endocrinology, 135, 76–82.
13. DACOSTA THM, WILLIAMSON DH, WARD A, BATES P, FISHER R, RICHARDSON L, HILL D, ROBINSON ICAF and GRAHAM CF. (1994). High plasma insuHn-hke growth factor-II (IGF-II) and low lipid content in transgenic mice. Measurements of lipid metabolism. J, Endocrinol., 143, 433–439.
14. DECHIARA TM, EFSTRATLADIS A and ROBERTSON EJ. (1990). A growth deficiency phototype in heterozygous mice carrying an insuHn-hke growth factor II gene disrupted by targeting. Nature, 345, 78–80.
15. DONOVAN SM, HINTZ RL and ROSENFELD RG. (1991a). Insulinlike growth factors I and II and their binding proteins in human milk: effect of heat treatment on IGF and IGF binding protein stabihty. J, Ped. Gastroent. Nutr., 13, 242–253.
16. DONOVAN SM, HINTZ RL, WILSON DM and ROSENFELD RG. (1991b). Insulin-like growth factors I and II and their binding proteins in rat milk. Pediatr. Res., 29, 50–55.
17. DULBECCO R and VOGT M. (1954). Plaque formation and isolation of pure lines with poliomyelitis viruses. J, Exp. Med., 99, 167–182.
18. EDWARDS PAW, WARD JL and BRADBURY JM. (1988). Alterations of morphogenesis by the x-myc oncogene in transplants of the mammary gland. Oncogene, 2, 407–412.
19. FLETCHER L, RIDER C, TAYLOR CB, ADAMSON ED, LUKE BM and GRAHAM CF. (1978). Enolase lsenzymes as markers of differentiation of teratocarcinoma cells. Dev. Biol., 65, 211–224.
20. FRANCIS GL, UPTON FM, BALLARD FJ, MCNEIL KA and WALLACE JC. (1988). Insulin-like growth factors 1 and 2 in bovine colostrum. Biochem. J., 251, 95–103.
21. GUENETTE RS, CORBEIL HB, LEGER J, WONG K, MEZL V, MOOIBROEK M and TENNISWOOD M. (1994). Induction of gene expression during involution of the lactating mammary gland of the rat. J, Mol. Endocrinol., 12, 47–60.
22. HALL JM, LEE MK, NEWMAN B, MORROW JE, ANDERSON LA, HUEY B and KING M-C. (1990). Linkage of early-onset familial breast cancer to chromosome 17q21. Science, 250, 1684–1689.
23. HARRINGTON EA, BENNETT MR, FANIDI A and EVAN GI. (1994). c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EM BO, J., 13, 3286–3295.
24. HARRIS S, ALI S, ANDERSON S, ARCH I BOLD AL and CLARK AJ. (1988). Complete nucleotide sequence of the genomic fl-lactoglobulin gene. Nucleic Acids Res., 16, 10379–10380.
25. HASELBACHER GK, IRMINGER JC, ZAPF J, ZIEGLER WH and HUMBEL RE. (1987). Insulin like growth factor II in human adrenal phaeochromocytomas and Wilms’ tumours: expression at the RNA and protein level. Proc. Natl Acad. Sci. USA., 84, 1104–1106.
26. HERBERT E, HERBELIN C and BOUGNOUX P. (1994). Analysis of the IGF-II receptor gene copy number in breast carcinoma. Br. J. Cancer, 69, 120-124
27. HILL DJ. (1990). Relative abundance and molecular size of immune-reactive insulin-like growth factors I and II in human fetal tissues. Early Hum. Dev., 21, 49–58.
28. HOGAN BLM, COSTANTINI F and LACY E. (1986). Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York.
29. LEE JE, TANTRAVAHL U, BOYLE AL and EFST RATI ADIS A. (1993). Parental imprinting of an Igf-2 transgene. Mol. Reprod. Dev., 35, 382–390.
30. MELTON DA KREIG PA, REBAGLIATI MR, MANIATIS T, ZINN K and GREEN MR. (1984). Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res., 12, 7035–7056.
31. MILAZZO G, GIORGINO F, DAMANTE G, SUNG S, STAMPFER MR, VIGNERI R, GOLDFINE ID and BELFIORE A. (1992). Insulin receptor expression and function in human breast cancer cell fines. Cancer Res., 52, 3924–3930.
32. NEWELL S, WARD A and GRAHAM CF. (1994). Discriminating translation of Insulin-like growth factor-II (IGF-II) during mouse embryogenesis. Mol. Reprod. Dev., 39, 249–258.
33. NIELSEN FC. (1992). The molecular and cellular biology of insulinlike growth factor II, Prog. Growth Factor Res., 4, 257–290.
34. PEYRAT JP and BONNETERRE J. (1992). Type 1 IGF receptor in human breast diseases. Breast Cancer Res. Treat., 22, 59–67.
35. RATHJEN PD, NICHOLS J, TOTH S, EDWARDS JR, HEATH JK and SMITH AG. (1990). Developmentally programmed induction of differentiation inhibiting activity in the control of stem cell populations. Genes Dev. 4, 2308–2318.
36. ROGLER CE, YANG D, ROSSETTI L, DONOHOE J, ALT E, CHANG CJ, ROSENFELD R, NEELY K and HINTZ R. (1994). Altered body composition and increased frequency of diverse malignancies in Insulin-like growth factor-II transgenic mice. J. Biol. Chem., 269, 13779–13784.
37. ROTWEIN P and HALL LJ. (1990). Evolution of insulin-like growth factor II: characterization of the mouse IGF-II gene and identification of two pseudo-exons. DNA Cell Biol. 9, 725–735.
38. SAKAKURA T, NISHIZUKA Y and DAWE CJ. (1976). Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland. Science. 194, 1439–1441.
39. SQUARTINI F and PINGITORE R. (1994). Tumours of the mammary gland. In Pathology of Tumours in Laboratory Animals, vol 2: Tumours of the Mouse. VS Turusov and U Mohr, (eds.) pp. 47-100. International Agency for Research on Cancer (WHO): Lyon.
40. WANG TC, CARDIFF RD, ZUKERBERG L, LEES E, ARNOLD A and SCHMIDT EV. (1994). Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature, Lond. 369, 669–671.
41. WARD A BATES P, FISHER R, RICHARDSON L and GRAHAM CF (1994). Disproportionate growth in mice with Igf-2 transgenes. Proc. Natl Acad. Sci. USA. 91, 10365–10369.
42. WEBSTER MA and MULLER WJ. (1994). Mammary tumorigenesis and metastasis in transgenic mice. Seminars in Cancer Biology. 5, 69–76.
43. WHITELAW CBA, HARRIS S, MCCLENAGHAN M, SIMONS JP and CLARK AJ. (1992). Position-independent expression of the ovine /Mactoglobufin gene in transgenic mice. Biochem. J. 286, 31–39.
44. WILLIAMSON DH. (1991). Regulation of adipose tissue mass and metabolism. In Obesity and Cachexia. Rothwell NJ and Stock MJ (eds.) pp. 63-101. John Wiley: New York.
45. XY a) mice. J, Heredity. 77, 151–158.
46. WOLFF GL. (1987). Body weight and cancer. Am. J. Clin. Nutr. 45, 168–180.
47. WOOSTER R, NEUHAUSEN SL, MANGION J, QUIRK Y, FORD D, COLLINS N, NGUYEN K, SEAL S, TRAN T, AVERILL D, FIELDS P, MARSHALL G, NAROD S, LENOIR GM, LYNCH H, FEUNTEUN J, DEVI LEE P, CORNELISSE CJ, MENKO FH, DALY PA, ORMISTON W, MCMANUS R, PYE C, LEWIS CM, CANNON-ALBRIGHT LA, PETO J, PONDER BAJ, SKOLNICK MH, EASTON DF, GOLDGAR DE and STRATTON MR. (1994). Localization of a breast cancer susceptibility gene, BRAC2, to chromosome 13q 12-13. Science, 265, 2088–2090.
48. YEE D. (1992). Can insulin-like growth factors regulate breast cancer growth? Breast Cancer Res. Treat., 22, 3–5.