Heteroarylaminoethyl and heteroarylthioethyl imidazoles. Synthesis and H3-receptor affinity

European Journal of Medicinal Chemistry

Volumn 30, Issue 11, 1995, Pages 881-889

  Plazzi, P V ^a   Bordi, F ^a   Mor, M ^a   Silva, C ^a   Morini, G ^a   Caretta, A ^a   Barocelli, E ^a   Vitali, T ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

heteroarylglaminoethylimidazole; heteroarylthioethylimidazole; histamine H3 receptor affinity; rat brain cortex membrane; 3H N methylhistamine

Indexed keywords

HISTAMINE H3 RECEPTOR; IMIDAZOLE DERIVATIVE; N METHYLHISTAMINE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0028876319     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/0223-5234(96)88307-3     Document Type: Article

References (33)

1. Highly potent and selective ligands for histamine H3-receptors
2. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
3. Highly potent and selective ligands for histamine H3-receptors
4. Carbon disulfide as a 2-.pi. component in its cycloaddition with 1-azirines