Esters of 3-Pyridylacetic Acid That Combine Potent Inhibition of 17α-Hydroxylase/C17,20-Lyase (Cytochrome P45017α) with Resistance to Esterase Hydrolysis

Journal of Medicinal Chemistry

Volumn 38, Issue 21, 1995, Pages 4191-4197

  Rowlands, Martin G ^a   Barrie, S Elaine ^a   Chan, Ferdinand ^a   Houghton, John ^a   Jarman, Michael ^a   McCague, Raymond ^a   Potter, Gerard A ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 2 (3 PYRIDYL)PROPIONIC ACID 1 ADAMANTYL ESTER; 2 METHYL 2 (3 PYRIDYL)PROPIONIC ACID 2 METHYL 2 ADAMANTYL ESTER; ISOPINOCAMPHEOL 2 METHYL 2 (3 PYRIDYL)PROPANOATE; PROPIONIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; PROSTATE CANCER; RAT;

ADAMANTANE; ANIMAL; ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS; COMPARATIVE STUDY; DRUG RESISTANCE; ENZYME INHIBITORS; ESTERASES; ESTERS; FEMALE; HUMAN; HYDROLYSIS; MALE; MICROSOMES, LIVER; PLACENTA; PROPIONATES; PROSTATIC NEOPLASMS; RATS; STEROID 17-ALPHA-HYDROXYLASE; SUPPORT, NON-U.S. GOV'T; TESTIS;

EID: 0028876284     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00021a008     Document Type: Article

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