Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice

Endocrinology

Volumn 136, Issue 12, 1995, Pages 5311-5321

  Singh, Jaskirat ^a,c   O’neill, Chris ^c   Handelsman, David J ^a,b,c  

^a School of Obstetrics and Gynaecology   (Australia)

^b Departments of Respiratory Medicine   (Australia)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTANOLONE; GONADOTROPIN; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE DELETION; GERM CELL; HORMONAL REGULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERTOLI CELL; SPERMATOGENESIS; TESTIS BIOPSY;

ANDROGENS; ANIMAL; BODY WEIGHT; FEMALE; FERTILIZATION; FOLLICLE STIMULATING HORMONE; GONADORELIN; HYPOGONADISM; MALE; MICE; ORGAN WEIGHT; SPERM COUNT; SPERMATOGENESIS;

EID: 0028876068     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo.136.12.7588276     Document Type: Article

References (88)

1. Smith P 1927 The disabilities caused by hypophysectomy and their repair. JAMA 88:158-161
2. Greep R, Fevold H, Hisaw F 1936 Effects of two hypophyseal gonadotropic hormones on the reproductive system of the male rat. Anat Rec 65:261-71
3. Steinberger E 1971 Hormonal control of mammalian spermatogenesis. Physiol Rev 51:1-22
4. Sharpe RM 1994 Regulation of spermatogenesis. In: Knobil E, Neill JD (eds) The Physiology of Reproduction. Raven Press, New York, pp 1363-1434
5. Lyon MF, Glenister PH, Lamoreux ML 1975 Normal spermatozoa from androgen resistant germ cells of chimaeric mice and the role of androgen in spermatogenesis. Nature 258:620-622
6. Cattanach BM, Iddon CA, Charlton HM, Chiappa SA, Fink G 1977 Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 269:338-340
7. Lang J 1991 Assay for deletion in GnRH (hpg) locus using PCR. Mouse Genome 89:857
8. Mason AJ, Hayflick JS, Zoeller RT, Young WS, Phillips HS, Nikolics K, Seeburg PH 1986 A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse. Science 234:1366-1371
9. Robb GW, Amann RP, Killian GJ 1978 Daily sperm production and epididymal sperm reserves of pubertal and adult rats. J Reprod Fertil 54:103-107
10. Puri V, Puri CP, Anand Kumar TC 1981 Serum levels of dihydrotestosterone in male rhesus monkeys estimated by a non-chro-matographic radioimmunoassay method. J Steroid Biochem 14:877-881
11. Russell LD, Ettlin RA, Sinha Hikim AP, Clegg ED 1990 Histological and Histopathological Evaluation of the Testis. Cache River Press, Clearwater
12. de Hoff RJ, Rhines FN 1961 Determination of the number of particles per unit volume from measurements made on random plane sections: the general cylinder and ellipsoid. Trans Metallurg Soc AIME 221:975-982
13. Wing TY, Christensen AK 1982 Morphometrie studies on rat seminiferous tubules. Am J Anat 165:13-25
14. Elias H, Hyde DM 1980 An elementary introduction to stereology (quantitative microscopy). Am J Anat 159:412-446
15. Zhengwi Y, Wreford NG, De Kretser DM 1990 A quantitative study of spermatogenesis in the developing rat testis. Biol Reprod 43:629-635
16. Quinn P, Warnes GM, Kerin JF, Kirby C 1985 Culture factors affecting the success rate of in vitro fertilisation and embryo transfer. Ann NY Acad Sei 442:195-203
17. Bartlett JMS, Weinbauer GF, Nieschlag E 1989 Differential effects of FSH and testosterone on the maintenance of spermatogenesis in the adult hypophysectomized rat. J Endocrinol 121:49-58
18. Huang HFS, Marshall GR, Rosenberg R, Nieschlag E 1987 Restoration of spermatogenesis by high levels of testosterone in hypophy-sectomised rats after long-term regression. Acta Endocrinol (Copenh) 116:433-444
19. Marshall GR, Wickings EJ, Ludecke DK, Nieschlag E 1983 Stimulation of spermatogenesis in stalk sectioned rhesus monkeys by testosterone alone. J Clin Endocrinol Metab 57:152-159
20. Vihko KK, Lapolt PS, Nishimori K, Hsueh AJW 1991 Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats. Endocrinology 129:1926-1932
21. Rea MA, Marshall GR, Weinbauer GF, Nieschlag E 1986 Testosterone maintains pituitary and serum FSH and spermatogenesis in gonadotrophin-releasing hormone antagonist-suppressed rats. J Endocrinol 108:101-107
22. Rea MA, Weinbauer GF, Marshall GR, Nieschlag E 1987 Testosterone stimulates pituitary and serum FSH in GnRH antagonist-suppressed rats. Acta Endocrinol (Copenh) 113:487-492
23. Weinbauer GF, Gockeler E, Nieschlag E 1988 Testosterone prevents complete suppression of spermatogenesis in the gonadotropin-releasing hormone antagonist-treated nonhuman primate (Macaca fascicularis). J Clin Endocrinol Metab 67:284-290
24. Bhasin S, Fielder TJ, Swerdloff RS 1988 Testosterone selectively increases serum follicle-stimulating hormonal (FSH) but not luteinizing hormone (LH) in gonadotropin-releasing hormone antagonist-treated male rats: evidence for differential regulation of LH and FSH secretion. Biol Reprod 37:55-9
25. McLachlan RI, Wreford NG, Tsonis C, De Kretser DM, Robertson DM 1994 Testosterone effects on spermatogenesis in the gonadotropin-releasing hormone-immunized rat. Biol Reprod 50:271-280
26. Awoniyi CA, Santulli R, Sprando RL, Ewing LL, Zirkin BR 1989 Restoration of advanced spermatogenic cells in the experimentally regressed rat testis: quantitative relationship to testosterone concentration within the testis. Endocrinology 124:1217-1223
27. Awoniyi CA, Sprando RL, Santulli R, Chandrashekar V, Ewing LL, Zirkin BR 1990 Restoration of spermatogenesis by exogenously administered testosterone in rats made azoospermic by hypophy-sectomy or withdrawal of luteinizing hormone alone. Endocrinology 127:177-184
28. Awoniyi CA, Zirkin BR, Chandrashekar V, Schlaff WD 1992 Exogenously administered testosterone maintains spermatogenesis quantitatively in adult rats actively immunized against gonadotropin-releasing hormone. Endocrinology 130:3283-3288
29. Sun YT, Irby DC, Robertson DM, De Kretser DM 1989 The effects of exogenously administered testosterone on spermatogenesis in intact and hypophysectomised rats. Endocrinology 125:1000-1010
30. Bartke A, Goldman BD, Bex FJ, Kelch RP, Dalterio S, Doherty PC, Smith MS 1980 Effect of prolactin on testicular regression and recrudescence in the golden hamster. Endocrinology 106:167-172
31. Dombrowicz D, Sente B, Closset J, Hennen G 1992 Dose-dependent effects of human prolactin on the immature hypohysectomized rat testis. Endocrinology 130:695-700
32. Van Haaster LH, De Jong FH, Docter R, De Rooij DG 1993 High neonatal triiodothyronine levels reduce the period of Sertoli cell proliferation and accelerate tubular lumen formation in the rat testis, and increase serum inhibin levels. Endocrinology 133:755-760
33. Luton JP, Thiebolt P, Valcke JC, Mahoudeau JA, Bricaire H 1977 Reversible gonadotropin deficiency in male Cushing’s syndrome. J Clin Endocrinol Metab 45:488-495
34. Charlton HM, Halpin DMG, Iddon C, Rosie R, Levy G, Mcdowell IFW, Megson A, Morris JF, Broadhead J, Davey-Smith G, Fink G 1983 The effects of daily administration of single and multiple injections of gonadotropin-releasing hormone on pituitary and gonadal function in the hypogonadal (hpg) mouse. Endocrinology 113: 535-544
35. Mason AJ, Pitts SL, Nikolics K, Szonyi E, Wilcox JN, Seeburg PH, Stewart TA 1986 The hypogonadal mouse: reproductive functions restored by gene therapy. Science 234:1372-1378
36. Kreiger DT, Perlow MJ, Gibson MJ, Davies TF, Zimmerman EA, Ferin M, Charlton HM 1982 Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency. Nature 298:468-471
37. Silverman AJ, Silverman RC, Gibson MJ 1990 Repair of reproductive deficits by neural transplantation. Biol Reprod 42:29-38
38. Silverman AJ, Roberts JL, Dong KW, Miller GM, Gibson MJ 1992 Intrahypothalamic injection of a cell line secreting gonadotropin-releasing hormone results in cellular differentiation and reversal of hypogonadism in mutant mice. Proc Natl Acad Sci USA 89:10668-10672
39. Chen H, Chandrashekhar V, Zirkin BR 1994 Can spermatogenesis be maintained quantiatively in intact adult rats with exogenously administered dihydrotestosterone? J Androl 15:132-138
40. Oakberg EF 1956 Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium. Am J Anat 99:507-516
41. Faucher CJ, Berger M, de Turckheim M, Veyssiere G, Jean C 1978 Developmental patterns of plasma and testicular testosterone in mice from birth to adulthood. Acta Endocrinol (Copenh) 89:780-788
42. Cunningham GR, Huckins C 1979 Persistence of complete spermatogenesis in the presence of low intratesticular concentrations of testosterone. Endocrinology 105:177-186
43. Sun YT, Wreford NG, Robertson DM, De Kretser DM 1990 Quantitative cytological studies of spermatogenesis in intact and hypophysectomised rats: identification of androgen-dependent stages. Endocrinology 127:1215-1223
44. Kerr JB, Maddocks S, Sharpe RM 1992 Testosterone and FSH have independent, synergistic and stage-dependent effects upon spermatogenesis in the rat testis. Cell Tissue Res 268:179-189
45. Cooke PS, Porcelli J, Hess RA 1992 Induction of increased testis growth and sperm production in adult rats by neonatal administration of the goitrogen propylthiouracil (PTU): the critical period. Biol Reprod 46:146-154
46. Joyce KL, Porcelli J, Cooke PS 1993 Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse. J Androl 14:448-455
47. Defranca L, Hess R, Cooke P, Russell L 1995 Neonatal hypothyroidism causes delayed Sertoli cell maturation in rats treated with propylthiouracil-evidence that the Sertoli cell controls testis growth. Anat Rec 242:57-69
48. Johnson L, Carter GK, Varner DD, Taylor TS, Blanchard TL, Rembert MS 1994 The relationship of daily sperm production with number of Sertoli cells and testicular size in adult horses: role of primitive spermatogonia. J Reprod Fertil 100:315-321
49. Orth JM, Gunsalus GL, Lamperti AA 1988 Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development. Endocrinology 122:787-794
50. Kluin PM, Kramer MF, de Rooij DG 1984 Proliferation of spermatogonia and Sertoli cells in maturing mice. Anat Embryol 169: 73-78
51. Vergouwen RPFA, Jacobs SGPM, Huiskamp R, Davids JAG, De Rooij DG 1991 Proliferative activity of gonocytes, Sertoli cells and interstitial cells during testicular development in mice. J Reprod Fertil 93:233-243
52. Arslan M, Weinbauer GF, Khan S, Nieschlag E 1989 Testosterone and dihydrotestosterone, but not estradiol, selectively maintain pituitary and serum follicle-stimulating hormone in gonadotropin-releasing hormone antagonist treated male rats. Neuroendocrinology 49:395-401
53. Pavlou SN, Brewer K, Farley MG, Lindner J, Bastias MC, Rogers BJ, Swift LL, Rivier JE, Vale WW, Conn PM, Flerbert CM 1991 Combined administration of a gonadotropin-releasing hormone antagonist and testosterone in men induces reversible azoospermia without loss of libio. J Clin Endocrinol Metab 73:1360-1369
54. Tom L, Bhasin S, Salameh W, Steiner B, Peterson M, Sokol R, Rivier J, Vale WW, Swerdloff RS 1992 Induction of azoospermia in normal men with combined Nal-Glu GnRH antagonist and testosterone enanthate. J Clin Endocrinol Metab 75:476-483
55. Bagatell CJ, Matsumoto AM, Christensen RB, Rivier JE, Bremner WJ 1993 Comparison of a gonadotropin-releasing hormone antagonist plus testosterone (T) vs. T alone as a potential male contraceptive. J Clin Endocrinol Metab 77:427-432
56. Spiteri-Grech J, Nieschlag E 1993 Paracrine factors relevant to the regulation of spermatogenesis-a review. J Reprod Fertil 98:1-14
57. Turner TT, Howards SS, Gleavy JL 1990 On the maintenance of male fertility in the absence of native testosterone secretion: site directed hormonal therapy in the rat. Fertil Steril 54:149-156
58. Boccabella AV 1963 Reinitiation and restoration of spermatogenesis with testosterone propionate and other hormones after a long term post-hypophysectomy period. Endocrinology 72:787-798
59. Ahmad N, Haltmeyer GC, Eik-Nes KB 1973 Maintenance of spermatogenesis in rats with intratesticular implants containing testosterone or dihydrotestosterone (DHT). Biol Reprod 8:411-419
60. Ahmad N, Haltmeyer GC, Eik-Nes K 1975 Maintenance of spermatogenesis with testosterone or dihydrotestosterone in hypophy-sectomized rats. J Endocrinol 44:103-107
61. Chowdhury AK, Tcholakian RK 1979 Effects of various doses of testosterone propionate on intratesticular and plasma testosterone levels and maintenance of spermatogenesis in adult hypophysec-tomized rats. Steroids 34:151-162
62. Buhl AE, Comette JC, Kirton KT, Yuan YD 1982 Hypophysecto-mised male rats treated with polydimethylsiloxane capsules containing testosterone: effects on spermatogenesis, fertility, and reproductive tract concentrations of androgens. Biol Reprod 27:183-188
63. Santulli R, Sprando RL, Awoniyi CA, Ewing LL, Zirkin BR 1990 To what extent can spermatogenesis be maintained in the hypophy-sectomised adult rat testis with exogenously administered testosterone? Endocrinology 126:95-101
64. Marshall GR, Wickings EJ, Nieschlag E 1984 Testosterone can initiate spermatogenesis in an immature nonhuman primate, Macaca fascicularis. Endocrinology 114:2228-2232
65. Ludwig DJ 1950 The effect of androgen on spermatogenesis. Endocrinology 46:453-481
66. Woods MC, Simpson ME 1961 Pituitary control of the testis of the hypophysectomised rat. Endocrinology 69:91-125
67. Lostroh AJ 1963 Effect of follicle-stimulating hormone and interstitial cell-stimulating hormone on spermatogenesis in Long-Evans rats hypophysectomised for six months. Acta Endocrinol (Copenh) 43:592-600
68. Lostroh AJ, Johnson R, Jordan CW 1963 Effect of ovine gonadotrophins and antiserum to interstitial cell-stimulating hormone on the testis of the hypophysectomized rat. Acta Endocrinol (Copenh) 44:536-544
69. Zirkin BR, Santulli R, Awoniyi CA, Ewing LL 1989 Maintenance of advanced spermatogenic cells in the adult rat testis: quantitative relationship to testosterone concentration within the testis. Endocrinology 124:3043-3049
70. Russell LD, Alger LE, Nequin LG 1987 Hormonal control of pubertal spermatogenesis. Endocrinology 120:1615-1632
71. Huang RFS, Nieschlag E 1986 Suppression of the intratesticular testosterone is associated with quantitative changes in spermato-gonial populations in intact adult rats. Endocrinology 118:619-626
72. Kierszenbaum AL 1994 Mammalian spermatogenesis in vivo and in vitro: a partnership of spermatogenic and somatic cell lineages. Endocr Rev 15:116-134
73. Matsumoto AM 1989 Hormonal control of spermatogenesis. In: Burger H, de Kretser DM (eds) The Testis. Raven Press, New York, pp 181-196
74. Barenetsky NG, Carlson HE 1980 Persistence of spermatogenesis in hypogonadotropic hypogonadism treated with testosterone. Fertil Steril 34:477-482
75. Bagatell CJ, Paulsen CA, Bremner WJ 1994 Preservation of fertility despite subnormal gonadotropin and testosterone levels after cessation of pulsatile gonadotropin-releasing hormone therapy in a man with Kallmann’s syndrome. Fertil Steril 61:392-394
76. Steinberger E, Root A, Ficher M, Smith KD 1973 The role of androgens in the initiation of spermatogenesis in man. J Clin Endocrinol Metab 37:746-751
77. Schaison G, Young J, Pholsena M, Nahoul K, Couzinet B 1993 Failure of combined follicle-stimulating hormone-testosterone administration to initiate and/or maintain spermatogenesis in men with hypogonadotropic hypogonadism. J Clin Endocrinol Metab 77:1545-1549
78. Chandolia RK, Weinbauer GF, Fingscheidt U, Bartlett JMS, Neischlag E 1991 Effects of flutamide on testicular involution induced by an antagonist of gonadotrohin-releasing hormone and on stimulation of spermatogenesis by follicle-stimulating hormone in rats. J Reprod Fertil 93:313-323
79. Russell LD, Corbin TJ, Borg KE, de Franca LR, Grasso P, Bartke A1993 Recombinant human follicle-stimualting hormone is capable of exerting a biological effect in the adult hypophysectomised rat by reducing the numbers of degenerating germ cells. Endocrinology 133:2062-2070
80. MacLuscky NJ, Naftolin F1981 Sexual differentiation of the central nervous system. Science 211:1294-1303
81. Corbier P, Edwards DA, Roffi J 1991 The neonatal testosterone surge: a comparative study. Arch Int Physiol 100:127-131
82. Riley JC, Behrman HR 1991 Oxygen radicals and reactive oxygen species in reproduction. Proc Soc Exp Biol Med 198:781-791
83. Aitken RJ 1994 A free radical theory of male infertility. Reprod Fertil Dev 6:19-24
84. Plapinger L, McEwen BS 1978 Gonadal steroid-brain interactions in sexual differentiation. In: Hutchinson JB (eds) Biological Determinants of Sexual Behaviour. Wiley and Sons, Chicester, pp 174-219
85. Corbier P, Kerdelhue B, Picon R, Roffi J 1978 Changes in testicular weight and serum gonadotropin and testosterone levels before, during, and afterbirth in the perinatal rat. Endocrinology 103:1985-1991
86. Mann DR, Gould KG, Collins DC, Wallen K 1989 Blockade of neonatal activation of the pituitary-testicular axis: effect on peripubertal luteinizing hormone and testosterone secretion and on testicular development in male monkeys. J Clin Endocrinol Metab 68:600-607
87. Winter JSD, Hughes IA, Reyes FI, Faiman C 1976 Pituitary-gonadal relations in infancy. II. Patterns of serum gonadal steroid concentrations in man from birth to two years of age. J Clin Endocrinol Metab 42:679-686
88. Livne I, Silverman AJ, Gibson MJ 1992 Reversal of reproductive deficiency in the hpg male mouse by neonatal androgenization. Biol Reprod 47:1-7