Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation

FEBS Letters

Volumn 375, Issue 3, 1995, Pages 289-293

  Leighton, Ian A ^a   Dalby, Kevin N ^a   Barry Caudwell, F ^a   Cohen, Patricia T W ^a   Cohen, Philip ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

MAP kinase; Protein kinase; Protein phosphorylation; Ribosomal protein S6; S6 kinase; Site directed mutagenesis

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CLONING, MOLECULAR; COMPARATIVE STUDY; DNA PRIMERS; KINETICS; LIVER; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; RATS; RECOMBINANT PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEIN S6 KINASES, 90KD; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0028875925     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(95)01170-J     Document Type: Article

References (37)

1. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
2. An analysis of the substrate specificity of insulin-stimulated protein kinase-1, a mammalian homologue of S6 kinase-II