Correlation of cyclic AMP accumulation and relaxant actions of salmeterol and salbutamol in bovine tracheal smooth muscle

British Journal of Pharmacology

Volumn 116, Issue 5, 1995, Pages 2510-2516

  Ellis, Karen E ^a   Mistry, Rajendra ^a   Boyle, John P ^a   Challiss, R A John ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

cyclic AMP accumulation; phosphoinositide turnover; salbutamol; salmeterol; smooth muscle relaxation; Adrenoceptor agonists

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CYCLIC AMP; HISTAMINE; INOSITOL PHOSPHATE; METHACHOLINE; SALBUTAMOL; SALMETEROL;

ANIMAL TISSUE; ARTICLE; CATTLE; DRUG POTENCY; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; SPASMOLYSIS; TRACHEA MUSCLE;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMAL; CATTLE; COMPARATIVE STUDY; CYCLIC AMP; HISTAMINE ANTAGONISTS; IN VITRO; INOSITOL 1,4,5-TRISPHOSPHATE; METHACHOLINE CHLORIDE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; PARASYMPATHOMIMETICS; RECEPTORS, ADRENERGIC, BETA-2; SECOND MESSENGER SYSTEMS; SUPPORT, NON-U.S. GOV'T; TRACHEA;

EID: 0028874982     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1995.tb15103.x     Document Type: Article

References (33)

1. Why are long‐acting β‐adrenoceptor agonists long‐acting?
2. 2adrenoceptor agonist: characterization of pharmacological activity in vitro and in vivo
3. A simple and sensitive saturation assay method for the measurement of adenosine 3′ 5′‐cyclic monophosphate
4. Inhibition of histamine‐stimulated phos‐phoinositide hydrolysis in bovine tracheal smooth muscle by BRL 38227 and isoprenaline
5. Second messenger and ionic modulation of agonist‐stimulated phosphoinositide turnover in airway smooth muscle
6. Comparative effects of BRL 38227, nitrendipine and isoprenaline on carbachol‐ and histamine‐stimulated phosphoinositide metabolism in airway smooth muscle
7. Phosphoinositide metabolism in airway smooth muscle
8. Effects of membrane depolarization and changes in intra‐ and extra‐cellular calcium concentration on phosphoinositide hydrolysis in bovine tracheal smooth muscle
9. +‐channels in trachealis muscle: electrophysiological and mechanical studies in guinea‐pig tissue
10. +‐channels in trachealis muscle: electrophysiological and mechanical studies in guinea‐pig tissue
11. 2+‐linked increase in coupled cyclic AMP synthesis and hydrolysis is an early event in cholinergic and P‐adrenergic stimulation of parotid secretion
12. 2‐adrenoceptor agonist salmeterol in guinea‐pig trachea
13. Correlation of cyclic AMP accumulation and relaxant actions of salmeterol in bovine tracheal smooth muscle: comparison with salbutamol
14. Effect of charybdotoxin on inhibition of histamine‐stimulated inositol phospholipid hydrolysis by isoprenaline, salbutamol and salmeterol in bovine tracheal smooth muscle
15. Putative substrates for cyclic nucleotide‐dependent protein kinases and the control of airway smooth muscle tone
16. Inhibition of histamine‐stimulated inositol phospholipid hydrolysis by agents which increase cyclic AMP levels in bovine trachea smooth muscle
17. β‐Adrenoceptor stimulation inhibits histamine‐stimulated inositol phospholipid hydrolysis in bovine tracheal smooth muscle
18. A way of looking at agonism and antagonism: Lessons from salbutamol, salmeterol and other β‐adrenoceptor agonists
19. Salmeterol: a novel drug for the treatment of asthma
20. 2‐adrenoceptor agonists with higher efficacy on guinea‐pig trachea and human bronchus in vitro
21. Neuronally released (−)−noradrenaline relaxes smooth muscle of calf trachea mainly through β‐adrenoceptors: comparison with (−)−adrenaline and relation to adenylate cyclase stimulation
22. The regulation of adenylyl cyclase by receptor‐operated G proteins
23. Protein measurement with the folin phenol reagent. J
24. Differential inhibitory effects of forskolin, isoproterenol and dibutyryl cyclic adenosine monophosphate on phosphoinositide hydrolysis in canine tracheal smooth muscle
25. Salmeterol, a new inhaled beta 2‐adrenergic agonist, has a longer blocking effect than albuterol on hyperventilation‐induced bronchoconstriction
26. 2‐adrenoceptor agonist mediating cyclic AMP accumulation in a neuronal cell line
27. Relaxant effects and durations of action of formoterol and salmeterol on isolated human bronchus
28. Effects of β‐adrenoceptor agonists in human bronchial smooth muscle
29. 2‐adrenoceptor agonist, salmeterol
30. Comparison of the effects of salmeterol and formoterol on airway tone and responsiveness over 24 h in bronchial asthma
31. Equilibrium and kinetic studies of the interactions of salmeterol with membrane bilayers
32. Onset of action and duration of effect of formoterol and salmeterol compared to salbutamol in isolated guinea‐pig trachea with or without epithelium
33. 2‐adrenoceptor agonist: comparison with salbutamol in adult asthmatic patients