Virus-induced immunosuppression: Immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression

Journal of Virology

Volumn 69, Issue 2, 1995, Pages 1059-1070

  Borrow, Persephone ^a   Evans, Claire F ^a   Oldstone, Michael B A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; IMMUNE DEFICIENCY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS PATHOGENESIS; VIRUS RECOMBINATION;

EID: 0028873681     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.69.2.1059-1070.1995     Document Type: Article

References (70)

1. Ahmed, R., C. S. Hahn, T. Somasundaram, L. Villarete, M. Matloubian, and J. H. Strauss. 1991. Molecular basis of organ-specific selection of viral variants during chronic infection. J. Virol. 65:4242-4247.
2. Ahmed, R., A. Salmi, L. D. Butler, J. M. Chiller, and M. B. A. Oldstone. 1984. Selection of genetic variants of LCMV in spleens of persistently infected mice. J. Exp. Med. 160:521-540.
3. Ahmed, R., R. S. Simon, M. Matloubian, S. R. Kolhekar, P. J. Southern, and D. M. Freedman. 1988. Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus. J. Virol. 62:3301-3308.
4. Ahmed, R., and J. G. Stevens. 1990. Viral persistence, p. 241-265. In Virology, 2nd ed. B. N. Fields and D. M. Knipe (ed.), Raven Press, Ltd., New York.
5. Althage, A., B. Odermatt, T. Moskophidis, T. Kundig, U. Hoffman-Rohrer, H. Hengartner, and R. M. Zinkernagel. 1992. Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation. Eur. J. Immunol. 22:1803-1812.
6. Armstrong, J. A., and R. Horne. 1984. Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy. Lancet ii:370-372.
7. Austyn, J. M., and S. Gordon. 1981. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur. J. Immunol. 11:805-815.
8. Beckford, A. P., R. O. C. Kaschula, and C. Stephen. 1985. Factors associated with fatal cases of measles: a retrospective autopsy study. S. Afr. Med. J. 68:858-863.
9. Borrow, P. Unpublished observation.
10. Borrow, P., and M. B. A. Oldstone. Unpublished observations.
11. Borrow, P., and M. B. A. Oldstone. 1992. Characterization of lymphocytic choriomeningitis virus-binding protein(s): a candidate cellular receptor for the virus. J. Virol. 66:7270-7281.
12. Borrow, P., and M. B. A. Oldstone. Measles virus: mononuclear cell interactions. Curr. Top. Microbiol. Immunol., in press.
13. Borrow, P., A. Tishon, and M. B. Oldstone. 1991. Infection of lymphocytes by a virus that aborts cytotoxic T lymphocyte activity and establishes persistent infection. J. Exp. Med. 174:203-212.
14. Breel, M., R. E. Mebius, and G. Kraal. 1987. Dendritic cells of the mouse recognized by two monoclonal antibodies. Eur. J. Immunol. 17:1555-1559.
15. Bruce, J., F. W. Symington, T. J. McKearn, and J. Sprent. 1981. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 127:2496-2501.
16. Buchmeier, M. J., R. M. Welsh, F. J. Dutko, and M. B. A. Oldstone. 1980. The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv. Immunol. 30:275-331.
17. Byrne, J. A., and M. B. A. Oldstone. 1984. Biology of cloned cytotoxic T lymphocytes specific for LCMV. Clearance of virus in vivo. J. Virol. 51:682-686.
18. Children's Vaccine Initiative. 1993. Measles control: resetting the agenda. Report of the CVI's ad hoc committee on an investment strategy for measles control. Bellagio, Italy.
19. Clerici, M., A. L. Landay, H. A. Kessler, R. A. Zajac, R. N. Boswell, S. C. Muluk, and G. M. Shearer. 1991. Multiple patterns of alloantigen presenting/stimulating cell dysfunction in patients with AIDS. J. Immunol. 146: 2207-2213.
20. Cobbold, S. P., A. Jayasuriya, A. A. Nash, T. D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T cell subsets in vivo. Nature (London) 312:548-551.
21. Cohen, J. 1993. What causes the immune system collapse seen in AIDS? Science 260:1256.
22. Crocker, P., and S. Gordon. 1989. Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody. J. Exp. Med. 169:1333-1346.
23. Dutko, F. J., and M. B. A. Oldstone. 1983. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains. J. Gen. Virol. 64:1689-1698.
24. Fung-Leung, W. P., T. M. Kundig, R. M. Zinkernagel, and T. W. Mak. 1991. Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J. Exp. Med. 174:1425-1429.
25. Gordon, S., P. R. Crocker, S. H. Lee, L. Morris, and S. Rabinowitz. 1986. In R. M. Steinman and R. J. North (ed.), Host-resistance mechanisms to infectious agents, tumors and allografts, p. 121-137. Rockefeller University Press, New York.
26. Helbert, M. R., J. Lage-Stehr, and N. A. Mitchison. 1993. Antigen presentation, loss of immunological memory, and AIDS. Immunol. Today 14:340-344.
27. Hengel, H., M. Lindner, H. Wagner, and K. Heeg. 1987. Frequency of herpes simplex virus-specific murine cytotoxic T lymphocyte precursors in mitogen-and antigen-driven primary in vitro T cell responses. J. Immunol. 139:4196-4202.
28. Horohov, D. W., and B. T. Rouse. 1986. Virus-induced immunosuppression. Vet. Clin. North Am. Small Anim. Pract. 16:1097-1127.
29. Inaba, K., and R. M. Steinman. 1984. Resting and sensitized T lymphocytes exhibit stimulatory (antigen presenting cell) requirements for growth and lymphocytic release. J. Exp. Med. 160:1717-1735.
30. King, C. C., B. D. Jamieson, K. Reddy, N. Bali, R. J. Concepcion, and R. Ahmed. 1992. Viral infection of the thymus. J. Virol. 66:3155-3160.
31. Kohler, M., B. Rüttner, S. Cooper, H. Hengartner, and R. M. Zinkernagel. 1990. Enhanced tumor susceptibility of immunocompetent mice infected with lymphocytic choriomeningitis virus. Cancer Immunol. Immunother. 32: 117-124.
32. Kraal, G., M. Breel, M. Janse, and G. Bruin. 1986. Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J. Exp. Med. 163:981-987.
33. Kraal, G., M. Rep, and M. Janse. 1987. Macrophages in T and B cell compartments and other tissue macrophages recognized by monoclonal antibody MOMA-2. Scand. J. Immunol. 26:653-661.
34. Langhoff, E., and R. M. Steinman. 1989. Clonal expansion of human T lymphocytes initiated by dendritic cells. J. Exp. Med. 169:315-320.
35. Leist, T. P., E. Rüedi, and R. M. Zinkernagel. 1988. Virus-triggered immune suppression in mice caused by virus-specific cytotoxic T cells. J. Exp. Med. 167:1749-1754.
36. Lo, D., C. R. Reilly, B. Scott, R. Liblau, H. O. McDevitt, and L. C. Burkly. 1993. Antigen-presenting cells in adoptively transferred and spontaneous autoimmune diabetes. Eur. J. Immunol. 23:1693-1698.
37. Macatonia, S. E., M. Gompels, A. J. Pinching, S. Patterson, and S. C. Knight. 1992. Antigen presentation by macrophages but not by dendritic cells in human immunodeficiency virus (HIV) infection. Immunology 75: 576-581.
38. Macatonia, S. E., R. Lau, S. Patterson, A. J. Pinching, and S. C. Knight. 1990. Dendritic cell infection, depletion and dysfunction in HIV-infected individuals. Immunology 71:38-45.
39. Matloubian, M., S. R. Kolhekar, T. Somasundaram, and R. Ahmed. 1993. Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 67:7340-7349.
40. McChesney, M. B., and M. B. A. Oldstone. 1989. Virus-induced immunosuppression: infections with measles virus and human immunodeficiency virus. Adv. Immunol. 45:335-380.
41. Merson, M. H. 1993. Slowing the spread of HIV: agenda tor the 1990s. Science 260:1266-1268.
42. Metlay, J. P., M. D. Witmer-Pack, R. Agger, M. T. Crowley, D. Lawless, and R. M. Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171:1753-1771.
43. Mims, C. A. 1986. Interactions of viruses with the immune system. Clin. Exp. Immunol. 66:1-16.
44. + class I-restricted antiviral cytotoxic T cells in vivo. J. Virol. 66: 3661-3668.
45. Murphy, F. A., M. J. Buchmeier, and W. E. Rawls. 1977. The reticuloendothelium as the target in a virus infection. Pichinde virus pathogenesis in two strains of hamsters. Lab. Invest. 37:502-515.
46. Nussenzweig, M. C., R. M. Steinman, M. D. Witmer, and B. Gutchinov. 1982. A monoclonal antibody specific for mouse dendritic cells. Proc. Natl. Acad. Sci. USA 79:161-165.
47. Odermatt, B., M. Eppler, T. P. Leist, H. Hengartner, and R. M. Zinkernagel. 1991. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc. Natl. Acad. Sci. USA 88:8252-8256.
48. Oldstone, M. B. A. 1987. Immunotherapy for virus infection. Curr. Top. Microbiol. Immunol. 134:211-229.
49. Oldstone, M. B. A. 1989. Viral persistence. Cell 56:517-520.
50. Oldstone, M. B. A. 1991. Molecular anatomy of viral persistence. J. Virol. 65:6381-6386.
51. Oldstone, M. B. A., A. Tishon, J. M. Chiller, W. O. Weigle, and F. J. Dixon. 1973. Effect of chronic viral infection on the immune system. I. Comparison of the immune responsiveness of mice chronically infected with LCM virus with that of noninfected mice. J. Immunol. 110:1268-1278.
52. b haplo-type reveal genetic control of isotype expression. J. Immunol. 126:317-321.
53. Parekh, B. S., and M. J. Buchmeier. 1986. Proteins of LCMV: antigenic topography of the viral glycoproteins. Virology 153:168-178.
54. Pircher, H., K. Burki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (London) 342:559-561.
55. Riviere, Y., R. Ahmed, P. J. Southern, M. J. Buchmeier, F. J. Dutko, and M. B. A. Oldstone. 1985. The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2. J. Virol. 53:966-968.
56. Roost, H., S. Charan, R. Gobet, E. Ruedi, H. Hengartner, A. Althage, and R. M. Zinkernagel. 1988. An acquired immune suppression in mice caused by infection with LCMV. Eur. J. Immunol. 4:511-518.
57. Rüedi, E., H. Hengartner, and R. M. Zinkernagel. 1990. Immunosuppression in mice by lymphocytic choriomeningitis virus infection: time dependence during primary and absence of effects on secondary antibody response. Cell. Immunol. 130:501-512.
58. Salvato, M., P. Borrow, E. Shimomaye, and M. B. A. Oldstone. 1991. Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence. J. Virol. 65:1863-1869.
59. Salvato, M. S., and E. M. Shimomaye. 1989. The completed sequence of lymphocytic choriomeningitis virus reveals a unique RNA structure a gene for a zinc finger protein. Virology 173:1-10.
60. -). Virology 104:517-522.
61. Southern, P. J., M. K. Singh, Y. Riviere, D. R. Jacoby, M. J. Buchmeier, and M. B. A. Oldstone. 1987. Molecular characterization of the genomic S RNA segment from lymphocytic choriomeningitis virus. Virology 157:145-155.
62. Sprent, J., and M. Schaefer. 1985. Properties of purified T cell subset. I. In vitro responses to class I vs. class II H-2 alloantigens. J. Exp. Med. 162:2068-2088.
63. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
64. Swiggard, W. J., R. M. Nonacs, M. D. Witmer-Pack, and R. M. Steinman. 1992. Enrichment of dendritic cells by plastic adherence and EA rosetting, p. 3.7.1-3.7.11. In J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober (ed.), Current protocols in immunology, vol. 2. Greene Publishing Associates and Wiley-Interscience, New York.
65. Tenner-Racz, K., P. Racz, M. Dietrich, and P. Kern. 1985. Altered follicular dendritic cells and virus-like particles in AIDS and AIDS-related lymphadenopathy. Lancet i:105-106.
66. Tishon, A., P. Borrow, C. Evans, and M. B. Oldstone. 1993. Virus-induced immunosuppression. I. Age at infection relates to a selective or generalized defect. Virology 195:397-405.
67. Whittle, H. C., and W. C. Marshall. 1987. Measles, p. 5.89-5.93. In D. J. Weatherall, J. G. G. Ledingham, and D. A. Warrell (ed.), Oxford textbook of medicine, 2nd ed. Oxford University Press, Oxford.
68. Wilson, M. C., and G. A. Higgins. 1989. In situ hybridization, p. 239-284. In A. A. Goultong, G. B. Baker, and A. T. Campagnoni (ed.), Neuromethods, vol. 16. Molecular neurobiological techniques. Humana Press, Clifton, N.J.
69. Wright, K. E., and M. J. Buchmeier. 1991. Antiviral antibodies atternuate T-cell-mediated immunopathology following acute lymphocytic choriomeningitis virus infection. J. Virol. 65:3001-3006.
70. Wu-Hsieh, B., D. H. Howard, and R. Ahmed. 1988. Virus-induced immunosuppression: a murine model of susceptibility of opportunistic infection. J. Infect. Dis. 158:232-235.