Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum

Molecular and Biochemical Parasitology

Volumn 69, Issue 1, 1995, Pages 135-138

  Basco, Leonardo K ^a,b   de Pécoulas, Philippe Eldin ^a,b   Wilson, Craig M ^c   Le Bras, Jacques ^b   Mazabraud, André ^a  

^a CNRS   (France)

^b BICHAT HOSPITAL   (France)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Antifolate; Drug resistance; Malaria; Polymerase chain reaction; Proguanil

Indexed keywords

CYCLOGUANIL; DIHYDROFOLATE SYNTHETASE; PROGUANIL; PYRIMETHAMINE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; NONHUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; DRUG RESISTANCE, MULTIPLE; HUMAN; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; POINT MUTATION; PYRIMETHAMINE; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE; TRIAZINES;

ANIMALIA; PLASMODIUM FALCIPARUM;

EID: 0028872311     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(94)00207-4     Document Type: Article

References (14)

1. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
2. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria
3. Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resisance in Plasmodium falciparum
4. Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum
5. Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance
6. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria
7. Plasmodium falciparum: drug sensitivity in vitro of isolates before and after adaptation to continuous culture
8. In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum
9. In vitro susceptibility of Cambodian isolates of Plasmodium falciparum to halofantrine, pyronaridine, and artemisinin derivatives
10. In vitro study of drug sensitivity of Plasmodium falciparum: An evaluation of a new semi-microtest
11. Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene
12. Prevalence of the dihydrofolate reductase Asn-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon
13. Plasmodium falciparum: Three amino acid changes in the dihydrofolate reductase of a pyrimethamine-resistant mutant
14. Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine