Low-molecular-weight heparin for the treatment of acute ischemic stroke

New England Journal of Medicine

Volumn 333, Issue 24, 1995, Pages 1588-1594

  Kay, Richard ^a   Wong, ka Sing ^a   yu, Yuk Ling ^a   Chan, Yuk Wah ^a   Tsoi, Tak Hong ^a   Ahuja, Anil T ^a   Chan, fu Luk ^a   Fong, ka Yeung ^a   Law, Chun Bong ^a   Wong, Agatha ^a   Woo, Jean ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

NADROPARIN;

AGED; ARTICLE; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

ACTIVITIES OF DAILY LIVING; ACUTE DISEASE; AGED; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; CEREBRAL INFARCTION; CEREBROVASCULAR DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LOGISTIC MODELS; MALE; NADROPARIN; TREATMENT OUTCOME;

EID: 0028871958     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199512143332402     Document Type: Article

References (31)

1. Kay R, Woo J, Kreel L, Wong HY, Teoh R, Nicholls MG Stroke subtypes among Chinese living in Hong Kong: the Shatin Stroke Registry. Neurology 1992; 42: 985-987
2. Barnett HJM, Eliasziw M, Meldrum HE Drugs and surgery in the prevention of ischemic stroke. N Engl J Med 1995; 332: 238-248
3. Marshall RS, Mohr JP Current management of ischaemic stroke. J Neurol Neurosurg Psychiatry 1993; 56: 6-16
4. Adams HP Jr, Brott TG, Crowell RM, Guidelines for the management of patients with acute ischemic stroke: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke 1994; 25: 1901-1914
5. Marsh EE III, Adams HO Jr, Biller J, Use of antithrombotic drugs in the treatment of acute ischemic stroke: a survey of neurologists in practice in the United States. Neurology 1989; 39: 1631-1634
6. Miller VT, Hart RG Heparin anticoagulation in acute brain ischemia. Stroke 1988; 19: 403-406
7. Phillips SJ An alternative view of heparin anticoagulation in acute focal brain ischemia. Stroke 1989; 20: 295-298
8. Scheinberg P Heparin anticoagulation. Stroke 1989; 20: 173-174
9. Caplan LR to heparinize or not: an unsettled issue. Stroke 1989; 20: 968-968
10. Rothrock JF, Hart RG Antithrombotic therapy in cerebrovascular disease. Ann Intern Med 1991; 115: 885-895
11. Biller J, Love BB, Gordon De Antithrombotic therapy for ischemic cerebrovascular disease. Semin Neurol 1991; 11: 353-367
12. Prandoni P, Lensing AWA, Buller HR, Comparison of subcutaneous low-molecular-weight heparin with intravenous standard heparin in proximal deep-vein thrombosis. Lancet 1992; 339: 441-445
13. Hull RD, Raskob GE, Pineo GF, Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis. N Engl J Med 1992; 326: 975-982
14. Kakkar VV, Cohen TC, Edmonson RA, Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. Lancet 1993; 341: 259-265
15. Leizorovicz A, Simonneau G, Decousus H, Boissel JP Comparison of efficacy and safety of low molecular weight heparins and unfractionated heparin in initial treatment of deep venous thrombosis: a meta-analysis. BMJ 1994; 309: 299-304
16. Hirsh J, Levine MN Low molecular weight heparin. Blood 1992; 79: 1-17
17. Kay R, Wong KS, Woo J Pilot study of low-molecular-weight heparin in the treatment of acute ischemic stroke. Stroke 1994; 25: 684-685
18. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 1991; 337: 1521-1526
19. Adams HP Jr, Bendixen BH, Kappelle LJ, Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial: TOAST: Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41
20. Anderson CS, Taylor BV, Hankey GJ, Stewart-Wynne EG, Jamrozik KD Validation of a clinical classification of subtypes of acute cerebral infarction. J Neurol Neurosurg Psychiatry 1994; 57: 1173-1179
21. Lindley RI, Warlow CP, Wardlaw JM, Dennis MS, Slattery J, Sandercock PAG Interobserver reliability of a clinical classification of acute cerebral infarction. Stroke 1993; 24: 1801-1804
22. Lindley RI, Waddell F, Livingstone M, Can simple questions assess outcome after stroke? Cerebrovasc Dis 1994; 4: 314-324
23. Wade DT, Hewer RL Functional abilities after stroke: measurement, natural history and prognosis. J Neurol Neurosurg Psychiatry 1987; 50: 177-182
24. Armitage P, Berry G. Statistical methods in medical research. 3rd ed. Oxford, England: Blackwell Scientific, 1994:403-7.
25. Sackett DL, Haynes RB, Tugwell P. Clinical epidemiology: a basic science for clinical medicine. Boston: Little, Brown, 1985:59-100.
26. Granger CV, Dewis LS, Peters NC, Sherwood CC, Barrett JE Stroke rehabilitation: analysis of repeated barthel index measures. Arch Phys Med Rehabil 1979; 60: 14-17
27. Sandercock PAG, van den Belt AGM, Lindley RI, Slattery J Antithrombotic therapy in acute ischaemic stroke: an overview of the completed randomised trials. J Neurol Neurosurg Psychiatry 1993; 56: 17-25
28. Shinar D, Gross CR, Bronstein KS, Reliability of the activities of daily living scale and its use in the telephone interview. Arch Phys Med Rehabil 1987; 68: 723-728
29. Candelise L, Pinardi G, Aritzu E, Musicco M Telephone interview for stroke outcome assessment. Cerebrovasc Dis 1994; 4: 341-343
30. Heiss WD, Huber M, Fink GR, Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab 1992; 12: 193-203
31. Warkentin TE, Levine MN, Hirsh J, Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995; 332: 1330-1335