Use of an antibody against the matrix metalloproteinase–generated aggrecan neoepitope fvdipen‐cooh to assess the effects of stromelysin in a rabbit model of cartilage degradation

Arthritis & Rheumatism

Volumn 38, Issue 10, 1995, Pages 1400-1409

  Bayne, Ellen Kahn ^a   MacNaul, KAREN L ^a   Donatelli, Susan A ^a   Christen, Amy ^a   Griffin, Patrick R ^a   Hoerrner, Lori A ^a   Calaycay, Jimmy R ^a   Ayala, Julia M ^a   Chapman, Kevin ^a   Hagmann, William ^a   Weidner, Jeffrey R ^a   Mcdonnell, Joseph ^a   Moore, Vernon L ^a   Mumford, Richard A ^a   Lark, Michael W ^a   Hutchinson, Nancy I ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; COLLAGENASE; STROMELYSIN;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARTILAGE DEGENERATION; DNA DETERMINATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODIES; BASE SEQUENCE; CARTILAGE, ARTICULAR; EPITOPES; INJECTIONS, INTRA-ARTICULAR; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PROTEOGLYCANS; RABBITS; STROMELYSIN 1; SYNOVIAL FLUID;

EID: 0028871942     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.1780381007     Document Type: Article

References (27)

1. Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury
2. Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis
3. Differential in vivo expression of collagenase messenger RNA in synovium and cartilage: quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis
4. Cartilage metalloproteinase genes are upregulated in experimental osteoarthritis and in isolated osteoarthritic chondrocytes in culture (abstract)
5. Recombinant human interleukin‐β‐induced increase in levels of proteoglycans, stromelysin, and leukocytes in rabbit synovial fluid
6. In vivo expression of stromelysin in synovium and cartilage of rabbits injected intraarticularly with interleukin‐1β
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8. Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones
9. Proteoglycans: isolation and characterization
10. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethyl‐methylene blue
11. Structural analysis of proteins by capillary HPLC electrospray tandem mass spectrometry
12. Quantification of a matrix metalloproteinase‐generated aggrecan GI fragment using monospecific anti‐peptide serum
13. Monoclonal antibodies against cartilage proteoglycan and link protein
14. Elicitation of a stromelysin‐specific neoepitope in the IGD region of aggrecan by the intraarticular injection of human stromelysin into rabbits (abstract)
15. Inhibition of matrix metalloproteinases by N‐carboxyalkyl peptides
16. Periodate‐lysine paraformaldehyde fixative: a new fixative for immunoelectron microscopy
17. Studies on the quantification of proteoglycans by the dimethylmethylene blue dye‐binding method: specificity, quantification in synovial lavage fluid, and automation
18. Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan: evidence for proteolysis at this site in vivo in human articular cartilage
19. Hyaluronan receptor‐directed assembly of chondrocyte pericellular matrix
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21. Stromelysins and PUMP cleave cartilage proteoglycan between G1 and G2 domains (abstract)
22. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain
23. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B
24. Cleavage of proteoglycan aggregate by leucocyte elastase
25. Aggrecan catabolism in cartilage: studies on the nature of a novel proteinase (aggrecanase) which cleaves the Glu 373‐Ala 374 bond of the interglobular domain (abstract)
26. VDIPEN, a metalloproteinasegenerated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis
27. Detection of a metalloproteinase‐generated aggrecan HABR fragment within human OA and RA cartilage (abstract)