Inhibition of E-Selectin-, ICAM-1-, and VCAM-1-Mediated Cell Adhesion by Benzo[b]thiophene-, Benzofuran-, Indole-, and Naphthalene-2-carboxamides: Identification of PD 144795 as an Antiinflammatory Agent

Journal of Medicinal Chemistry

Volumn 38, Issue 22, 1995, Pages 4597-4614

  Boschelli, Diane H ^a   Kramer, James B ^a   Khatana, Sonya S ^a   Sorenson, Roderick J ^a   Connor, David T ^a   Ferin, Mark A ^a   Wright, Clifford D ^a   Lesch, Mark E ^a   Imre, Kathleen ^a   Okonkwo, Godwin C ^a   Schrier, Denis J ^a   Conroy, Mary Carol ^a   Ferguson, Erika ^a   Woelle, Joachim ^a   Saxena, Uday ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHOXY 3 (1 METHYLETHOXY)BENZO[B]THIOPHENE 2 CARBOXAMIDE 1 OXIDE; ANTIINFLAMMATORY AGENT; BENZOTHIOPHENE DERIVATIVE; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; PD 144795; THIOGLYCOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADJUVANT DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG CONFORMATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NEUTROPHIL; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; PLEURISY; RAT; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION; VASCULAR ENDOTHELIUM;

ADMINISTRATION, ORAL; AMIDES; ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOFURANS; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMAN; INDOLES; INTERCELLULAR ADHESION MOLECULE-1; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NAPHTHALENES; NEUTROPHILS; THIOPHENES; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0028871572     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00022a026     Document Type: Article

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