Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto‐ATPase

British Journal of Pharmacology

Volumn 114, Issue 2, 1995, Pages 475-481

  Crack, B E ^a   Pollard, C E ^a   Beukers, M W ^a,b   Roberts, S M ^a   Hunt, S F ^a   Ingall, A H ^a   McKechnie, K C W ^a   IJzerman, A P ^a,b   Leff, P ^a  

^a SANOFI   (France)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

agonist potency orders; ATP; ecto ATPase; enzyme inhibition; FPL 67156; P2U purinoceptors; P2X purinoceptors; receptor classification

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; 6 N,N DIETHYL BETA,GAMMA ADENOSINE TRIPHOSPHATE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ACETYLCHOLINE; ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; AMILORIDE; BETA,GAMMA DIBROMOMETHYLENE 6 N,N DIETHYLADENOSINE TRIPHOSPHATE; BUMETANIDE; INDOMETACIN; NEW DRUG; PHOSPHORUS 32; PURINE P2 RECEPTOR; PURINE P2X RECEPTOR; PURINE P2Y2 RECEPTOR; PURINERGIC RECEPTOR AFFECTING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ANIMAL TISSUE; ARTICLE; BLOOD CELL; CHLORIDE TRANSPORT; CLASSIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG POTENCY; DRUG POTENTIATION; EAR ARTERY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; TRACHEA MUCOSA;

ADENOSINE TRIPHOSPHATE; ADENOSINETRIPHOSPHATASE; ANIMAL; CHLORIDES; EPITHELIAL CELLS; EPITHELIUM; HUMAN; IN VITRO; ION CHANNELS; MALE; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; RABBITS; RECEPTORS, PURINERGIC P2; URIDINE TRIPHOSPHATE;

EID: 0028871207     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1995.tb13251.x     Document Type: Article

References (15)

1. Characterization of ecto‐ATPase on human blood cells
2. 2‐purinoceptor
3. 2X‐purinoceptor ligands
4. The potentiation of the responses to noradrenaline and isoprenaline of the guinea‐pig isolated tracheal chain preparation by desipramine, cocaine, phentolamine, phenoxybenzamine, guanethidine, metanephrine and cooling
5. The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory
6. The relationship between cholinesterase inhibition in the chick biventer cervicis muscle and its sensitivity to exogenous acetylcholine
7. 2T‐purinoceptors
8. Errors in the measurement of agonist potency‐ratios produced by uptake processes: a general model applied to β‐adrenoceptor agonists
9. 2X‐receptors in the rabbit isolated ear artery
10. 2X‐purinoceptors in the rabbit ear artery
11. 2X‐purinoceptors in rabbit isolated ear artery
12. Quantitative estimation of overadditive and underadditive drug effects by means of theoretical, additive dose‐response curves
13. Purine receptors in the trachea: studies with adenosine deaminase and dipyridamole
14. 2‐purinoceptor
15. 2‐purinoceptors: evidence that dephosphorylation of ATP analogues reduces pharmacological potency