Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of β-amyloid in rat PC12 cells

Neuroscience Letters

Volumn 184, Issue 2, 1995, Pages 113-116

  Pollack, Scott J ^a   Sadler, Isobel I J ^a   Hawtin, Stuart R ^a   Tailor, Vipula J ^a   Shearman, Mark S ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

3 4,5 Dimethylthiazol 2 yl 2,5 diphenyltetrazolium bromide (MTT); Alzheimer's disease; Carageenan; Congo Red; Glycosaminoglycan; Heparan sulfate; sulfate; Amyloid

Indexed keywords

AMYLOID PROTEIN; CONGO RED; DYE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; PROTEOGLYCAN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; RAT;

AMYLOID BETA-PROTEIN; ANIMAL; CELL SURVIVAL; DYES; GLYCOSAMINOGLYCANS; OXIDATION-REDUCTION; PC12 CELLS; PEPTIDE FRAGMENTS; RATS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 0028870182     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(94)11182-I     Document Type: Article

References (27)

1. Hydrogen peroxide mediates amyloid β protein toxicity
2. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction
3. pH-Dependent binding of synthetic β-amyloid peptides to glycosaminoglycans
4. Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide
5. Reduction of a tetrazolium salt and superoxide generation in human tumor cells (HeLa)
6. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
7. Spectroscopic studies on the effect of pH on the interaction between Congo Red and amyloid-type proteins
8. Effects of sulfate ions on Alzheimer β/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions
9. Biochemistry of Alzheimer's disease amyloid plaques
10. Amyloid deposits and amyloidosis: the betafibrillosa (second of two parts)
11. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
12. Heparan sulfate proteoglycans in amyloidogenesis an epiphenomenon, a unique factor, or the tip of a more fundamental process
13. A critical analysis of postulated pathogenic mechanisms in amyloidogenesis
14. Quantitative evaluation of Congo Red binding to amyloid-like proteins with a beta-pleated sheet conformation
15. Binding of heparan sulfate glycosaminoglycan to β-amyloid peptide: inhibition by potentially therapeutic polysulfated compounds
16. Circular-dichroism studies on two murine serum amyloid A proteins
17. Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state
18. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death
19. Secondary structure of amyloid β-peptide correlates with neurotoxic activity in vitro
20. Studies on succinate reductase systems. III. Points of coupling of four different tetrazolium salts
21. Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses
22. Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease
23. Binding of the dye Congo Red to the amyloid protein pig insulin reveals a novel homology amongst amyloid-forming peptide sequences
24. Amyloid β protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid β protein
25. Influence of sulphate ions on the structure of AA amyloid fibrils
26. Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides
27. β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo Red