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Volumn 26, Issue 5, 1995, Pages 803-809

Investigation of the mechanism by which ketanserin prolongs the duration of the cardiac action potential

Author keywords

Action potential duration; Benzoyl piperidine; Ketanserin; Potassium currents; Serotonin (5 HT)2A 2C receptors

Indexed keywords

2 [(2 DIMETHYLAMINO 2 METHYLPROPYL)THIO] 3 PHENYLQUINOLINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; KETANSERIN TARTRATE; PENTOBARBITAL; PIPERIDINE DERIVATIVE; PIRENPERONE; POTASSIUM CHANNEL; RITANSERIN; SEROTONIN 1C RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN ANTAGONIST;

EID: 0028868956     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/00005344-199511000-00018     Document Type: Article
Times cited : (23)

References (22)
  • 1
    • 0023605666 scopus 로고
    • Ketanserin in essential hypertension: Use as monotherapy and in combination with a diuretic or ß-adrenoceptor antagonist
    • Cameron HA, Waller PC, Ramsay LE. Ketanserin in essential hypertension: use as monotherapy and in combination with a diuretic or ß-adrenoceptor antagonist. Br J Clin Pharmacol 1987:24:705-11.
    • (1987) Br J Clin Pharmacol , vol.24 , pp. 705-711
    • Cameron, H.A.1    Waller, P.C.2    Ramsay, L.E.3
  • 2
    • 0024517702 scopus 로고
    • The multicenter ketanserin research group. Incidence and clinical relevance of QT prolongation caused by the new selective serotonin antagonist ketanserin
    • Zehender M, Meinertz T, Hohnloser S, et al. The multicenter ketanserin research group. Incidence and clinical relevance of QT prolongation caused by the new selective serotonin antagonist ketanserin. Am J Cardiol 1989:63:826-32.
    • (1989) Am J Cardiol , vol.63 , pp. 826-832
    • Zehender, M.1    Meinertz, T.2    Hohnloser, S.3
  • 3
    • 0021264274 scopus 로고
    • Effects of pacing on triggered activity induced by early afterdepolarizations
    • Damiano BP, Rosen MR. Effects of pacing on triggered activity induced by early afterdepolarizations. Circulation 1984:69:1013-25.
    • (1984) Circulation , vol.69 , pp. 1013-1025
    • Damiano, B.P.1    Rosen, M.R.2
  • 4
    • 0022386591 scopus 로고
    • Serotonin and the heart: Effects of ketanserin on myocardial function, heart rate, and arrhythmias
    • Saman S, Thandroyen F, Opie LH. Serotonin and the heart: effects of ketanserin on myocardial function, heart rate, and arrhythmias. J Cardiovasc Pharmacol 1985:7(suppl 7):S70-5.
    • (1985) J Cardiovasc Pharmacol , vol.7 , pp. S70-S75
    • Saman, S.1    Thandroyen, F.2    Opie, L.H.3
  • 5
    • 0023878188 scopus 로고
    • Acute and chronic effects of ketanserin on the electrophysiologic properties of isolated rabbit ventricular myocardium: Particular reference to repolarization
    • Kamiya K, Venkatesh N, Singh BN. Acute and chronic effects of ketanserin on the electrophysiologic properties of isolated rabbit ventricular myocardium: particular reference to repolarization. Am Heart J 1988:115:1222-8.
    • (1988) Am Heart J , vol.115 , pp. 1222-1228
    • Kamiya, K.1    Venkatesh, N.2    Singh, B.N.3
  • 6
    • 0024409290 scopus 로고
    • Electrophysiologic effects of ketanserin on canine Purkinje fibers, ventricular myocardium and the intact heart
    • Zaza A, Malfatto G, Rosen MR. Electrophysiologic effects of ketanserin on canine Purkinje fibers, ventricular myocardium and the intact heart. J Pharmacol Ther Exp 1989:250:397-405.
    • (1989) J Pharmacol Ther Exp , vol.250 , pp. 397-405
    • Zaza, A.1    Malfatto, G.2    Rosen, M.R.3
  • 7
    • 0028060074 scopus 로고
    • Ketanserin inhibits depolarization-activated outward potassium current in rat ventricular myocytes
    • Zhang ZH, Boutjdir M, El-Sherif N. Ketanserin inhibits depolarization-activated outward potassium current in rat ventricular myocytes. Circ Res 1994:75:711-21.
    • (1994) Circ Res , vol.75 , pp. 711-721
    • Zhang, Z.H.1    Boutjdir, M.2    El-Sherif, N.3
  • 8
    • 0028959268 scopus 로고
    • Ketanserin inhibits the transient outward current in rabbit ventricular myocytes
    • Le Grand B, Marty A, Colpaert FC, John GW. Ketanserin inhibits the transient outward current in rabbit ventricular myocytes. J Cardiovasc Pharmacol 1995:25:341-4.
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 341-344
    • Le Grand, B.1    Marty, A.2    Colpaert, F.C.3    John, G.W.4
  • 9
    • 0022148018 scopus 로고
    • A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates
    • Mitra R, Morad M. A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates. Am J Physiol 1985;249:H1056-60.
    • (1985) Am J Physiol , vol.249 , pp. H1056-H1060
    • Mitra, R.1    Morad, M.2
  • 10
    • 0000169232 scopus 로고
    • An algorithm for least squares estimation of non-linear parameters
    • Marquardt DW. An algorithm for least squares estimation of non-linear parameters. J Soc Indust Appl Math 1963;11:431.
    • (1963) J Soc Indust Appl Math , vol.11 , pp. 431
    • Marquardt, D.W.1
  • 11
    • 0020051801 scopus 로고
    • A drug discrimination analysis of lysergic acid diethylamide (LSD): In vivo agonist and antagonist effects of purported 5-hydroxy-tryptamine antagonists and of pirenperone, a LSD-antagonist
    • Colpaert FC, Niemegeers CJE, Janssen PAJ. A drug discrimination analysis of lysergic acid diethylamide (LSD): in vivo agonist and antagonist effects of purported 5-hydroxy-tryptamine antagonists and of pirenperone, a LSD-antagonist. J Pharmacol Exp Ther 1982:221:206-14.
    • (1982) J Pharmacol Exp Ther , vol.221 , pp. 206-214
    • Colpaert, F.C.1    Niemegeers, C.J.E.2    Janssen, P.A.J.3
  • 12
    • 0021885892 scopus 로고
    • Behavioral and 5-HT antagonist effects of ritanserin: A pure and selective antagonist of LSD discrimination in rat
    • Colpaert FC, Meert TF, Niemegeers CJE, Janssen PAJ. Behavioral and 5-HT antagonist effects of ritanserin: a pure and selective antagonist of LSD discrimination in rat. Psychopharmacology 1985:86:45-54.
    • (1985) Psychopharmacology , vol.86 , pp. 45-54
    • Colpaert, F.C.1    Meert, T.F.2    Niemegeers, C.J.E.3    Janssen, P.A.J.4
  • 13
    • 10544236577 scopus 로고
    • In vitro pharmacology of ICI 170809, a new 5-HT, antagonist
    • A1404 (P6441)
    • Blackburn TP, Thornber CV, Pearce RJ, Cox B. In vitro pharmacology of ICI 170809, a new 5-HT, antagonist. FASEB J 1988;2:A1404 (P6441).
    • (1988) FASEB J , vol.2
    • Blackburn, T.P.1    Thornber, C.V.2    Pearce, R.J.3    Cox, B.4
  • 14
    • 0022559931 scopus 로고
    • 2 binding characteristics of l-(2.5-dimethoxy-4-bromophenyl)-2-aminopropane analogues
    • 2 binding characteristics of l-(2.5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem 1986:29:194-9.
    • (1986) J Med Chem , vol.29 , pp. 194-199
    • Glennon, R.A.1    McKenney, J.D.2    Lyon, R.A.3    Titeler, M.4
  • 15
    • 0021972633 scopus 로고
    • Action potential prolongation and induction of abnormal automaticity of low quinidine concentrations in canine Purkinje fibers
    • Roden DM, Hoffman BF. Action potential prolongation and induction of abnormal automaticity of low quinidine concentrations in canine Purkinje fibers. Circ Res 1985:56:857-67.
    • (1985) Circ Res , vol.56 , pp. 857-867
    • Roden, D.M.1    Hoffman, B.F.2
  • 16
    • 0021255108 scopus 로고
    • Frequency-dependent effects of antiarrhythmic drugs on action potential duration and refractoriness of canine cardiac Purkinje fibers
    • Nattel S, Zeng FD. Frequency-dependent effects of antiarrhythmic drugs on action potential duration and refractoriness of canine cardiac Purkinje fibers. J Pharmacol Exp Ther 1984:229:283-91.
    • (1984) J Pharmacol Exp Ther , vol.229 , pp. 283-291
    • Nattel, S.1    Zeng, F.D.2
  • 17
    • 0025910681 scopus 로고
    • Rate and concentration-dependent effects of UK-68,798, a potent new class III antiarrhythmic, on canine Purkinje fibre action potential duration and Vmax
    • Knilans TK, Lathrop DA, Nanasi PP, Schwartz A, Varro A. Rate and concentration-dependent effects of UK-68,798, a potent new class III antiarrhythmic, on canine Purkinje fibre action potential duration and Vmax. Br J Pharmacol 1991:103:1568-72.
    • (1991) Br J Pharmacol , vol.103 , pp. 1568-1572
    • Knilans, T.K.1    Lathrop, D.A.2    Nanasi, P.P.3    Schwartz, A.4    Varro, A.5
  • 18
    • 0020059648 scopus 로고
    • Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje fibers
    • Colatsky TJ. Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje fibers. Circ Res 1982:50:17-27.
    • (1982) Circ Res , vol.50 , pp. 17-27
    • Colatsky, T.J.1
  • 20
    • 0026635995 scopus 로고
    • Modulation of potassium channels by anti-arrhythmic and antihypertensive drugs
    • Sanguinetti MC. Modulation of potassium channels by anti-arrhythmic and antihypertensive drugs. Hypertension 1992:19:228-36.
    • (1992) Hypertension , vol.19 , pp. 228-236
    • Sanguinetti, M.C.1
  • 21
    • 0025963987 scopus 로고
    • Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea-pig myocytes: Mechanism of action
    • Sanguinetti MC, Jurkiewicz NK, Scott A, Siegl PKS. Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea-pig myocytes: mechanism of action. Circ Res 1991:68:77-84.
    • (1991) Circ Res , vol.68 , pp. 77-84
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2    Scott, A.3    Siegl, P.K.S.4
  • 22
    • 0027433995 scopus 로고
    • Mechanisms and control of repolarization
    • Carmeliet E. Mechanisms and control of repolarization. Eur Heart J 1993:14(suppl H):3-13.
    • (1993) Eur Heart J , vol.14 , pp. 3-13
    • Carmeliet, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.