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Volumn 7, Issue 5, 1995, Pages 682-686

Manipulation of costimulatory signals to enhance antitumor T-cell responses

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TUMOR ANTIGEN;

EID: 0028867835     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0952-7915(95)80077-8     Document Type: Article
Times cited : (158)

References (34)
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    • Analysis of lymphocyte costimulation in vivo using transgenic and ‘knockout’ mice
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  • 9
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    • of outstanding interest, This paper describes aspects of the immunity induced by several B7-1 transfected tumor cell lines. It shows that the longevity of protection differs in two different tumor models. Cross-protection is reported in two different tumor models. Elimination of a pre-existing tumor is also demonstrated. Finally, this paper reports that irradiation greatly diminishes immunogenicity of B7-transfected tumor cells.
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    • Townsend1    Su2    Atherton3    Allison4
  • 13
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    • + T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma
    • + cells are required for the effect.
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    • Li1    McGowan2    Hellstrom3    Hellstrom4    Chen5
  • 20
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    • Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 costimulatory molecules
    • of special interest, This paper demonstrates that B7-2 expression can result in tumor rejection and in induction of immunity in a manner similar to that of B7-1.
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    • Induction of antitumor immunity by recombinant vaccinia viruses expressing B7-1 or B7-2 costimulatory molecules
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    • of special interest, This paper reports that fusion of a tumor cell with an activated APC endows the tumor cell with the capacity to induce potent immunity.
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  • 27
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    • of special interest, This is an current review suggesting a promising strategy for immunotherapy.
    • (1995) Immunol Today , vol.16 , pp. 117-121
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  • 28
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    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
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    • of special interest, This paper and [31] describe methods for obtaining large numbers of dendritic cells from precursors in the blood of adults.
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    • CD28 and CTLA-4 deliver opposing signals which regulate the response of T cells to stimulation
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel1    Allison2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.