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Volumn 5, Issue 5, 1995, Pages 625-635

Regeneration in the adult mammalian CNS: guided by development

Author keywords

[No Author keywords available]

Indexed keywords

AGRIN; CADHERIN; CELL SURFACE PROTEIN; CYTOSKELETON PROTEIN; NERVE CELL ADHESION MOLECULE; NEUROTROPHIC FACTOR;

EID: 0028867747     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-4388(95)80068-9     Document Type: Article
Times cited : (113)

References (118)
  • 1
    • 0028909228 scopus 로고
    • Regeneration of the auditory midbrain intercommissural projection in organotypic culture
    • (1995) J Neurosci , vol.15 , pp. 1298-1307
    • Hafidi1    Sanes2    Hillman3
  • 2
    • 0028938453 scopus 로고
    • Extensive regeneration in vitro by early embryonic neurons on immature and adult CNS tissue
    • (1995) J Neurosci , vol.15 , pp. 2057-2062
    • Shewan1    Berry2    Cohen3
  • 3
    • 0028952435 scopus 로고
    • Type-specific stabilization and target-dependent survival of regenerating ganglion cells in the retina of adult rats
    • (1995) J Neurosci , vol.15 , pp. 1057-1079
    • Thanos1    Mey2
  • 4
    • 0028878068 scopus 로고
    • Functional synaptic connections made by regenerated retinal ganglion cell axons in the superior colliculus of adult hamsters.
    • of special interest, Responses to light in discrete areas of the visual field were recorded within the superficial laminae of the reinnervated superior colliculus. This study shows that regenerated retinal ganglion axon terminals make excitatory synapses with neurons of the superficial retino-recipient layers of the superior colliculus. In some cases, the input from a single retinal ganglion cell is sufficient to drive postsynaptic superior colliculus neurons to threshold for excitation, suggesting that convergence of inputs from regenerated retinal ganglion cell axons is not required for the activation of neurons from the superior colliculus in response to light.
    • (1995) J Neurosci , vol.15 , pp. 665-675
    • Sauvé1    Sawai2    Rasminsky3
  • 6
    • 0029013323 scopus 로고
    • Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery
    • of special interest, Following aspirative bilateral lesions of the septohippocampal projection in adult rats, temporary NGF infusions prevented long-term neuronal loss of septal cholinergic neurons. Furthermore, when these NGF infusions were combined with grafting of embryonic hippocampal cells into the lesion cavity, partial hippocampal reinnervation was achieved, resulting in functional recovery on a simple task assessing habituation.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4621-4625
    • Tuszynski1    Gage2
  • 7
    • 0029564661 scopus 로고
    • Axonal regeneration and limited functional recovery following hippocampal deafferentation.
    • of special interest, Adult rats received unilateral lesion of the fimbria—fornix pathway and grafts of primary fibroblasts genetically modified to produce NGF. The data show that these NGF-producing grafts allow axotomized septal cholinergic neurons to reinnervate the hippocampus and result in functional recovery on a simple task assessing habituation, but not on a more complex spatial memory task, such as the Morris water maze.
    • (1995) J Comp Neurol
    • Eagle1    Chalmers2    Clary3    Gage4
  • 8
    • 0026236554 scopus 로고
    • Facilitatory and inhibitory effects of glial cells and extracellular matrix in axonal regeneration
    • (1991) Curr Opin Neurobiol , vol.1 , pp. 407-413
    • Carbonetto1
  • 9
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes — implications for their role in neurological disease
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston1    Mucke2
  • 10
    • 0027343618 scopus 로고
    • Reactive glia as rivals in regulating neuronal survival
    • (1993) Glia , vol.7 , pp. 102-110
    • Giulian1
  • 12
    • 0028815823 scopus 로고
    • Neuron saving schemes
    • (1995) Nature , vol.373 , pp. 289-290
    • Lindsay1
  • 14
    • 0027972545 scopus 로고
    • Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon.
    • (1994) J Neurosci , vol.14 , pp. 335-347
    • Hyman1    Juhasz2    Jackson3    Wright4    Ip5    Lindsay6
  • 15
    • 0028800803 scopus 로고
    • The neurotrophins BDNF, NT-3 and NT-4/5 promote survival morphological and biochemical differentiation of striatal neurons in vitro
    • (1995) Eur J Neurosci , vol.7 , pp. 213-222
    • Ventimiglia1    Mather2    Jones3    Lindsay4
  • 17
    • 0028339815 scopus 로고
    • Neurotrophin-4 selectively promotes survival of striatal neurons in organotypic slice culture
    • (1994) Brain Res , vol.647 , pp. 340-344
    • Ardelt1    Flaris2    Roth3
  • 18
    • 0028206303 scopus 로고
    • Neurotrophin-4/5 (NT-4/5) increases adult rat retinal ganglion cell survival and neurite outgrowth in vitro
    • (1994) J Neurobiol , vol.25 , pp. 953-959
    • Cohen1    Bray2    Aguayo3
  • 20
    • 0027195615 scopus 로고
    • The neurotrophic factor concept: a reexamination
    • (1993) J Neurosci , vol.13 , pp. 2739-2748
    • Korsching1
  • 22
    • 0028063908 scopus 로고
    • Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors
    • (1994) Curr Opin Neurobiol , vol.4 , pp. 78-86
    • Baird1
  • 23
    • 0028172053 scopus 로고
    • Transforming growth factor-β promotes survival of midbrain dopaminergic neurons and protects them against N-methyl-4-phenylpyridinium ion toxicity
    • (1994) Neuroscience , vol.63 , pp. 1189-1196
    • Krieglstein1    Unsicker2
  • 25
    • 0028795044 scopus 로고
    • Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
    • of special interest, GDNF promotes the survival of dopaminergic neurons of substantia nigra in an adult rat model of axotomy by transection of the medial forebrain bundle. Daily intracerebral injections of rat recombinant GDNF allowed survival of more than 80% of dopaminergic neurons.
    • (1995) Nature , vol.373 , pp. 339-341
    • Beck1    Valverde2    Alexi3    Poulsen4    Moffat5    Vandlen6    Rosenthal7    Hefti8
  • 26
    • 0028874203 scopus 로고
    • GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo
    • (1995) Brain Res , vol.672 , pp. 104-111
    • Kearns1    Gash2
  • 27
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • of outstanding interest, In vivo effect of GDNF is investigated in the nigrostriatal system of the adult mouse after MPTP lesion. Intracerebral injections of GDNF in the striatum or the substantia nigra rescue the mesencephalic dopaminergic neurons. Dopamine levels and motor behavior are restored after GDNF administration. These results suggest that GDNF may be a potent therapeutic agent for the treatment of Parkinson's disease.
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac1    Lindqvist2    Lin3    Ögren4    Young5    Hoffer6    Olson7
  • 28
    • 0028109717 scopus 로고
    • GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
    • of special interest, GDNF treatment supports the survival of rat motoneurons both in vitro and in vivo. The protective effects of GDNF are compared with those of NGF and BDNF on both motoneurons and PNS neurons. This study suggests that GDNF is a good candidate for the treatment of motoneuron disease.
    • (1994) Science , vol.266 , pp. 1062-1064
    • Henderson1    Phillips2    Pollock3    Davies4    Lemeulle5    Armanini6    Simpson7    Moffet8    Vandlen9    Koliatsos10    Rosenthal11
  • 29
    • 0028874195 scopus 로고
    • Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
    • of special interest, GDNF rescues developing chick or mouse motoneurons from axotomy-induced and naturally programmed cell death in vivo, and promotes the survival cultured motoneurons. These data suggest that GDNF, either alone or associated with other neurotrophic factors, may be used in the treatment of amyotrophic lateral sclerosis and spinal muscular atrophy.
    • (1995) Nature , vol.373 , pp. 344-346
    • Oppenheim1    Houenou2    Johnson3    Lin4    Li5    Lo6    Newsome7    Prevette8    Wang9
  • 30
    • 0028854836 scopus 로고
    • In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons
    • of special interest, GDNF exerts neurotrophic effects in vivo on neonatal and adult rat facial motoneurons. GDNF is retrogradely transported by neonatal spinal motoneurons. Local application of GDNF to the transected facial nerve prevents motoneuronal cell death and atrophy occurring after axotomy in the neonatal period. In adulthood, local or systemic applications of GDNF attenuate the decrease of choline acetyltransferase immunostaining in the facial nucleus. Thus, GDNF exerts an important neurotrophic influence on developing and adult motoneurons in vivo.
    • (1995) Nature , vol.373 , pp. 341-344
    • Yan1    Matheson2    Lopez3
  • 31
    • 0028061313 scopus 로고
    • Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
    • of outstanding interest, This study showed that netrin-1 and netrin-2, two axonal outgrowth promoting proteins (see [33]), have a differential mRNA expression: netrin-1 mRNA is confined to floor plate cells, whereas netrin-2 is detected at lower levels in the ventral two-thirds of the spinal cord. Most importantly, the two netrin proteins exist in a diffusible form and could together establish a long-range gradient of tropic activity, guiding commissural axonal growth to the ventral midline of the spinal cord.
    • (1994) Cell , vol.12 , pp. 425-435
    • Kennedy1    Serafini2    De la Torre3    Tessier-Lavigne4
  • 32
    • 0029065329 scopus 로고
    • The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
    • of outstanding interest, The results of this study suggest that diffusible netrin-1 is a bifunctional guidance cue that attracts a group of ventrally directed axons while steering away trochlear motor axons that grow dorsally from the floor plate.
    • (1995) Cell , vol.81 , pp. 621-629
    • Colamarino1    Tessier-Lavigne2
  • 33
    • 0028138219 scopus 로고
    • The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
    • of outstanding interest, Purification from embryonic chick brain of two proteins, netrin-1 and netrin-2, and identification of a distinct activity that potentiates the outgrowth-promoting activity of the netrins in the rat commissural axons of the developing spinal cord.
    • (1994) Cell , vol.78 , pp. 409-424
    • Serafini1    Kennedy2    Galko3    Mirzayan4    Jessell5    Tessier-Lavigne6
  • 34
    • 0029024674 scopus 로고
    • Semaphorin II can function as a selective inhibitor of specific synaptic arborizations
    • (1995) Cell , vol.81 , pp. 631-639
    • Matthes1    Sink2    Kolodkin3    Goodman4
  • 35
    • 0029037182 scopus 로고
    • Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
    • of special interest, Semaphorin III/collapsin is a diffusible guidance molecule expressed by ventral spinal cord cells. Semaphorin III is able to pattern sensory projections by selectively repelling small diameter afferents subserving pain and temperature that are NGF responsive and normally terminate in the dorsal spinal cord.
    • (1995) Neuron , vol.14 , pp. 949-959
    • Messersmith1    Leonardo2    Shatz3    Tessier-Lavigne4    Goodman5    Kolodkin6
  • 36
    • 0029054199 scopus 로고
    • Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension
    • (1995) Neuron , vol.14 , pp. 941-948
    • Püschel1    Adams2    Betz3
  • 37
    • 0028804689 scopus 로고
    • Localized collapsing cues can steer growth cones without inducing their full collapse
    • of outstanding interest, Exposure of growth cones, from temporal retinal and dorsal root ganglion cells, to collapsing stimuli (such as the motility-inhibiting protein collapsin) frequently results in smooth turning of growth cones away from the stimuli, without inducing their full collapse. The results suggest that inhibitory guidance cues can steer growth cones through a localized inhibition of lamellipodial protrusion.
    • (1995) Neuron , vol.14 , pp. 263-274
    • Fan1    Raper2
  • 38
    • 0028219210 scopus 로고
    • Turning of nerve growth cones induced by neurotransmitters
    • 2+ may act as a second messenger in the cytoplasm of the growth cone to initiate the turning response.
    • (1994) Nature , vol.368 , pp. 140-144
    • Zheng1    Felder2    Connor3    Poo4
  • 39
    • 0028984150 scopus 로고
    • 2+)-calmodulin signaling in Drosophila growth cones leads to stalls in axon extension and errors in axon guidance
    • (1995) Neuron , vol.14 , pp. 43-56
    • VanBerkum1    Goodman2
  • 40
    • 0028817332 scopus 로고
    • A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth
    • of outstanding interest, The results show that a soluble chimeric form of the CAM L1 stimulates neurite outgrowth via the signal transduction cascade trigger by activation of the FGFR, in a similar if not identical manner then when initiated by membrane-bound L1. This paper raises an important issue about the ability of CAMs to promote neurite outgrowth independently of their function as substrate-associated adhesion molecules.
    • (1995) Neuron , vol.14 , pp. 57-66
    • Doherty1    Williams2    Walsh3
  • 41
    • 0028170989 scopus 로고
    • 2+ influx and neurite growth in response to purified N-cadherin and laminin
    • 2+ in neuronal cell bodies and growth cones, and a decrease in glial cells.
    • (1994) J Cell Biol , vol.127 , pp. 1461-1475
    • Bixby1    Grunwald2    Bookman3
  • 42
    • 0028170211 scopus 로고
    • Ectopic expression of connectin reveals a repulsive function during growth cone guidance and synapse formation
    • of special interest, Connectin seems to function as an attractive signal when coupled to its ability to mediate homophilic interactions between lateral embryonic muscles and SNa (segmental nerve a) motoneurons. In contrast, when connectin is expressed ectopically on ventral muscle, growth cones of SNb (segmental nerve b) motoneurons that normally innervate this target turn away from the connectin source, preventing synapse formation. These results suggest a repulsive function for connectin during motoneuron growth cone guidance and synapse formation.
    • (1994) Neuron , vol.13 , pp. 525-539
    • Nose1    Takeichi2    Goodman3
  • 43
    • 0028872784 scopus 로고
    • Laminin and fibronectin guide-posts signal sustained but opposite effects to passing growth cones
    • of special interest, Growth cone velocity, well beyond the time of contact, is increased by laminin and decreased by fibronectin on model guideposts. In addition, laminin provides unambiguous directional guidance information to the advancing growth cone. These laminin-evoked growth cone responses require activation of protein kinase C dependent intracellular signalling mechanisms.
    • (1995) Neuron , vol.14 , pp. 275-285
    • Kuhn1    Schmidt2    Kater3
  • 45
    • 0028353611 scopus 로고
    • The extracellular matrix molecule janusin regulates neuronal morphology in a substrate- and culture time-dependent manner
    • (1994) Eur J Neurosci , vol.6 , pp. 597-606
    • Lochter1    Taylor2    Fuss3    Schachner4
  • 46
    • 0028103938 scopus 로고
    • Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties
    • of special interest, A novel proteoglycan, DSD-1-PG, is purified from postnatal mouse brain extract. DSD-1-PG promotes neurite outgrowth of rat embryonic mesencephalic and hippocampal neurons.
    • (1994) J Cell Biol , vol.126 , pp. 783-799
    • Faissner1    Clement2    Lochter3    Streit4    Mandl5    Schachner6
  • 47
    • 0028053871 scopus 로고
    • T-Cadherin expression delineates specific regions of the developing motor axon-hindlimb projection pathway
    • (1994) J Neurosci , vol.14 , pp. 7331-7346
    • Fredette1    Ranscht2
  • 48
    • 0028109072 scopus 로고
    • N-cadherin and Ng-CAM/8D9 are involved serially in the migration of newly generated neurons into the adult songbird brain
    • (1994) Neuron , vol.13 , pp. 567-582
    • Barami1    Kirschenbaum2    Lemmon3    Goldman4
  • 50
    • 0027955570 scopus 로고
    • Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning
    • of special interest, NCAM-deficient mice appear healthy and fertile, and their motor abilities seem normal. However, they show a 10% reduction in overall brain weight, a 36% decrease in size of the olfactory bulb, and their spatial learning, as tested in the Morris water maze, is impaired. NCAM deficiency coincides with almost a total loss of PSA.
    • (1994) Nature , vol.367 , pp. 455-459
    • Cremer1    Lange2    Christoph3    Plomann4    Vopper5    Roes6    Brown7    Baldwin8    Kraemer9    Scheff10
  • 51
    • 0028067597 scopus 로고
    • N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid
    • of outstanding interest, NCAM mutation in mice and the injection of endoneuraminidase, destroying the PSA moiety associated with NCAM, produce an accumulation of precursors in the subependymal layer, probably due to a decrease in rostral migration of olfactory precursors. Radial migration of granule cells in the olfactory bulb is not affected by PSA removal. Therefore, PSA on NCAM-180 seems to play a key role in tangential cell migration of olfactory precursors in the subependymal layer of the rat.
    • (1994) Neuron , vol.13 , pp. 595-609
    • Ono1    Tomasiewicz2    Magnuson3    Rutishauser4
  • 52
    • 0028133485 scopus 로고
    • Polysialic acid regulates growth cone behavior during sorting of motor axons in the plexus region
    • of outstanding interest, Evidence for the permissive role of PSA on NCAM for axonal sorting by attenuating axon—axon fasciculation mediated by L1.
    • (1994) Neuron , vol.13 , pp. 405-414
    • Tang1    Rutishauser2    Landmesser3
  • 53
    • 0028832897 scopus 로고
    • Embryonic (PSA) N-CAM reveals chains of migrating neuroblasts between the lateral ventricle and the olfactory bulb of adult mice
    • of special interest, The immunoreactivity of PSA—NCAM precisely reveals the migratory pathway of subventricular zone cells to the core of the olfactory bulb in adult mice. The cell—cell arrangement of PSA—NCAM-positive cells suggests an important role for this molecule in migration of neuronal precursors and new models for mechanisms involved in tangential migration.
    • (1995) J Comp Neurol , vol.351 , pp. 51-61
    • Rousselot1    Lois2    Alvarez-Buylla3
  • 54
    • 0028029162 scopus 로고
    • Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM and N-cadherin
    • of outstanding interest, The neurite outgrowth stimulated by L1, NCAM and NCad implicates the activation of the FGFR and its second-messenger pathway. Furthermore, the authors identified a CAM homology domain in the FGF family of receptors that, once bound by specific antibodies, inhibits neurite outgrowth stimulated by L1, NCAM and NCad. Synthetic peptides derived from this domain can differentially and specifically inhibit neurite outgrowth stimulated by the above CAMs. In addition, a soluble L1—Fc chimera increases phosphotyrosine production on the same set of neuronal proteins that are phosphorylated following activation of the FGFR with bFGF.
    • (1994) Neuron , vol.13 , pp. 583-594
    • Williams1    Furness2    Walsh3    Doherty4
  • 55
    • 0027971705 scopus 로고
    • NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice
    • (1994) J Cell Biol , vol.127 , pp. 825-833
    • Beggs1    Soriano2    Maness3
  • 56
    • 0028347820 scopus 로고
    • Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1
    • (1994) Neuron , vol.12 , pp. 873-874
    • Ignelzi1    Miller2    Soriano3    Maness4
  • 57
    • 0028204441 scopus 로고
    • Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum
    • of special interest, The loss of NCAM—NCAM-stimulated axonal growth during development could be due to the insertion of 10 amino acids (called VASE) to the fourth immunoglobulin domain of NCAM. The authors suggest that the presence of the VASE sequence, even in a minority of NCAM receptors, can inhibit the neurite outgrowth response, possibly by preventing NCAM from binding to the FGFR in the plasma membrane.
    • (1994) J Cell Biol , vol.125 , pp. 427-436
    • Saffell1    Walsh2    Doherty3
  • 59
    • 0028147879 scopus 로고
    • Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance
    • of special interest, In Drosophila, increased levels of Fasciclin II in motoneuron growth cones and axons, and ectopic Fasciclin II expression on other cells encountered by the motoneurons alter growth cone guidance. The failure of these motoneurons to defasciculate might prevent them from responding to other guidance cues important for providing adequate innervation of the target area. In addition, this study shows that motoneurons can be diverted onto abnormal pathways by contact with Fasciclin II-positive cells in their environment.
    • (1994) Neuron , vol.13 , pp. 507-523
    • Lin1    Goodman2
  • 60
    • 0028346526 scopus 로고
    • Decrease in growth cone-neurite fasciculation by sensory or motor cells in vitro accompanies downregulation of Aplysia cell adhesion molecules by neurotransmitters
    • of special interest, The neuropeptides Phe-Met-Arg-Phe-amide (FMRFamide) and serotonin downregulate the expression of NCAM-like molecules in Aplysia (apCAM) on motor and sensory cells, respectively. The downregulation of apCAM leads to a significant reduction in fasciculation of growth cones with other neurites extending from homologous cells, and is mimicked by treatment with antibodies against apCAM.
    • (1994) J Neurosci , vol.14 , pp. 1413-1421
    • Peter1    Aronoff2    Wu3    Schacher4
  • 61
    • 0028150965 scopus 로고
    • Aplysia cell adhesion molecules and serotonin regulate sensory cell-motor cell interactions during early stages of synapse formation in vitro
    • (1994) J Neurosci , vol.14 , pp. 6886-6900
    • Zhu1    Wu2    Schacher3
  • 62
    • 0028220181 scopus 로고
    • Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor
    • (1994) Neuron , vol.12 , pp. 861-872
    • Taira1    Takaha2    Taniura3    Kim4    Miki5
  • 66
    • 0028216755 scopus 로고
    • Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)
    • (1994) J Biol Chem , vol.269 , pp. 12999-13004
    • Raulo1    Chernousov2    Carey3    Nolo4    Rauvala5
  • 69
    • 0028895717 scopus 로고
    • Absence of persistent spreading, branching, and adhesion in GAP-43-depleted growth cones
    • (1995) J Cell Biol , vol.128 , pp. 647-660
    • Aigner1    Caroni2
  • 70
    • 0028953495 scopus 로고
    • Growth cone advance is inversely proportional to retrograde F-actin flow
    • (1995) Neuron , vol.14 , pp. 763-771
    • Lin1    Forscher2
  • 71
    • 0028316882 scopus 로고
    • Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability
    • (1994) J Cell Sci , vol.107 , pp. 869-879
    • Esmaeli-Azad1    McCarty2    Feinstein3
  • 72
    • 0343858564 scopus 로고
    • Adhesive molecules of the cell surface and extracellular matrix in neural regeneration
    • A Gorio, Raven Press, Ltd, New York
    • (1993) Neuroregeneration , pp. 77-100
    • Carbonetto1    David2
  • 73
    • 0027440463 scopus 로고
    • Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system
    • (1993) Neurosci Res , vol.17 , pp. 265-290
    • Seki1    Arai2
  • 74
    • 0028088417 scopus 로고
    • A role for polysialylated neural cell adhesion molecule in lesion-induced sprouting in hippocampal organotypic cultures
    • of outstanding interest, The sprouting reaction triggered by a section of CA3—CA1 connections in hippocampal organotypic cultures is associated with the expression of PSA—NCAM on growing neurites. The enzymatic removal of PSA on NCAM significantly delays the sprouting reaction, suggesting the functional importance of PSA in this model.
    • (1994) Neuroscience , vol.61 , pp. 441-445
    • Muller1    Stoppini2    Wang3    Kiss4
  • 75
    • 0028346465 scopus 로고
    • Embryonic neural cell adhesion molecule (N-CAM) is elevated in the denervated rat dentate gyrus
    • of special interest, Following entorhinal cortex lesion, the expression of PSA—NCAM is upregulated on the surface of dendrites in the denervated zone and on sprouting axons. Interestingly, as reinnervation of the proximal dendritic field of the outer molecular layer is completed by the sprouting of commissural and associational afferents, PSA—NCAM expression returns to normal levels. However, the remaining part of the outer molecular layer, which is reinnervated by other afferents, maintains high expression of PSA—NCAM. These findings suggest that PSA—NCAM is important in the dendritic response to sprouting and synaptic remodeling, and that the source of reinnervating axons determines the response of the dendritic membrane of the target neurons.
    • (1994) J Neurosci , vol.14 , pp. 4217-4225
    • Miller1    Styren2    Lagenaur3    DeKosky4
  • 76
    • 0028151427 scopus 로고
    • Rapid expression and transport of embryonic N-CAM in the dentate gyrus following entorhinal cortex lesion: ultrastructural analysis
    • (1994) J Comp Neurol , vol.349 , pp. 486-492
    • Styren1    Lagenaur2    Miller3    DeKosky4
  • 77
    • 0028916593 scopus 로고
    • Alternate strategies in lesion-induced reactive synaptogenesis: differential expression of L1 in two populations of sprouting axons
    • of special interest, Temporal and spatial expressions of PSA—NCAM and L1 in the denervated zone following entorhinal cortex lesions are distinct. Shortly after entorhinal cortex lesions, L1 immunostaining declined in the outer molecular layer. Over 30 days post-lesion, L1 is expressed by sprouting commissural and associational afferents from the inner molecular layer. As L1-positive axons reinnervated this zone, PSA—NCAM staining appeared to recede. These changes in CAMs expression paralleled the known sequence of reactive synaptogenesis and axonal sprouting.
    • (1995) Exp Neurol , vol.131 , pp. 165-173
    • Styren1    Miller2    Lagenaur3    DeKosky4
  • 78
    • 0026538276 scopus 로고
    • The embryonic form of neural cell surface molecule (E-NCAM) in the rat hippocampus and its reexpression following kainic acid-induced status epilepticus
    • (1992) J Neurosci , vol.12 , pp. 872-882
    • Le Gal La Salle1    Rougon2    Valin3
  • 79
    • 0027414394 scopus 로고
    • Reactive astrocytes involved in the formation of lesional scars differ in the mediobasal hypothalamus and in other forebrain regions
    • (1993) J Neurosci Res , vol.34 , pp. 523-538
    • Alonso1    Privat2
  • 80
    • 0028927456 scopus 로고
    • Molecular characterization of eukaryotic polysialyltransferase-1
    • of outstanding interest, Cloning of the key enzyme, polysialyltransferase-1, responsible for PSA synthesis on NCAM. In reconstitution experiments, the enzyme induces PSA synthesis in all NCAM-expressing cell lines, providing evidence that a single enzymatic activity is required. The characterization of this enzyme gives new basis for studying the role of PSA in several fields of interest, including regeneration of the CNS.
    • (1995) Nature , vol.373 , pp. 715-718
    • Eckhardt1    Mühlenhoff2    Bethe3    Koopman4    Frosch5    Gerardy-Schahn6
  • 81
    • 0027314268 scopus 로고
    • Molecular profile of reactive astrocytes — implications for their role in neurological disease
    • (1993) Neuroscience , vol.54 , pp. 15-36
    • Eddleston1    Mucke2
  • 83
    • 0027714683 scopus 로고
    • Contact inhibition in the failure of mammalian CNS axonal regeneration
    • (1993) Bioessays , vol.15 , pp. 807-813
    • Johnson1
  • 90
    • 0027213847 scopus 로고
    • Sprouting and regeneration of lesioned corticospinal tract fibres in the adult rat spinal cord
    • (1993) Eur J Neurosci , vol.5 , pp. 1156-1171
    • Schnell1    Schwab2
  • 95
    • 0026585924 scopus 로고
    • Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines
    • (1992) Brain Res , vol.569 , pp. 14-25
    • Yoshida1    Gage2
  • 98
    • 0028126824 scopus 로고
    • Relationship between injury-induced astrogliosis, laminin expression and axonal sprouting in the adult rat brain
    • (1994) J Neurocytol , vol.23 , pp. 615-630
    • Stichel1    Müller2
  • 99
    • 0026345228 scopus 로고
    • Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor
    • (1991) Neuron , vol.7 , pp. 1019-1030
    • Kawaja1    Gage2
  • 101
    • 0029051425 scopus 로고
    • Neural cell adhesion molecule (N-CAM) inhibits astrocyte proliferation after injury to different regions of the adult rat brain
    • of special interest, Following cortical, hippocampal and striatal lesions, the population of dividing astrocytes is significantly smaller after infusion of NCAM or NCAM-related molecules. The authors raise the hypothesis that, by reducing glial proliferation, NCAM or its peptides may help create a more suitable environment for neuronal regeneration.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4323-4327
    • Krushel1    Sporns2    Cunningham3    Crossin4    Edelman5
  • 103
    • 0028958946 scopus 로고
    • Induction of L1 mRNA in PC12 cells by NGF is modulated by cell—cell contact and does not require the high-affinity NGF receptor
    • of special interest, In PC12 cells, one week exposure to NGF increases L1 mRNA levels by fourfold. The authors demonstrate that this regulation is independent of the high-affinity NGF receptor and is modulated by cell—cell contact but not cell—ECM interactions.
    • (1995) J Neurosci , vol.15 , pp. 2504-2512
    • Itoh1    Brackenbury2    Akeson3
  • 105
    • 0025984342 scopus 로고
    • Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes
    • of special interest, TGF-β1, TGF-β2 and NGF induce neurite outgrowth by increasing the expression of L1 by immature cultured astrocytes. TGF-β1 and TGF-β2 decrease the expression of NCAM by immature astrocytes. These factors do not modify the expression of adhesion molecules by mature astrocytes. An autocrine regulation of recognition molecule expression by NGF and TGF-β may play a key role in regulation of neuron—glia interactions after CNS lesion.
    • (1994) The Journal of Cell Biology , vol.115 , pp. 473-484
    • Saad1    Constam2    Ortmann3    Moos4    Fontana5    Schachner6
  • 107
    • 0028963635 scopus 로고
    • Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro
    • of special interest, In this study, the authors used antisense oligonucleotides to block APP expression. Oligonucleotides internalization was achieved by linking them to pAntp (the homeodomain of the Antennapedia trans-acting protein) that allows membrane translocation. The application of APP antisense oligonucleotides on cultured embryonic cortical neurons resulted in a marked decrease of APP synthesis and in the subsequent decrease in axon and dendrite outgrowth.
    • (1995) The Journal of Cell Biology , vol.128 , pp. 919-927
    • Alinquant1    Hantraye2    Mailleux3    Moya4    Bouillot5    Prochiantz6
  • 108
    • 0028136865 scopus 로고
    • Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension.
    • of special interest, The sequence of five amino acids 328–332 of APP induces neurite extension through cell-surface binding.
    • (1994) J Neurosci , vol.14 , pp. 5461-5470
    • Jin1    Ninomiya2    Roch3    Schubert4    Masliah5    Otero6    Saitoh7
  • 111
    • 0029257190 scopus 로고
    • Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
    • (1995) J Neurosci , vol.15 , pp. 2157-2167
    • Qiao Qiu1    Ferreira2    Miller3    Koo4    Selkoe5
  • 112
    • 0028344867 scopus 로고
    • Localization and alternative splicing of agrin mRNA in adult rat brain: transcripts encoding isoforms that aggregate acetylcholine receptors are not restricted to cholinergic neurons
    • of special interest, The level of expression and pattern of alternative splicing of agrin mRNA (agrin0, agrin8, agrin11, agrin19) are differentially regulated in the brain. Overall, agrin mRNA distribution in the adult brain is broad and predominantly neuronal, suggesting that agrin may play a role in the formation and maintenance of synapses between neurons in the CNS.
    • (1994) J Neurosci , vol.14 , pp. 1141-1152
    • O'Connor1    Lauterborn2    Gall3    Smith4
  • 113
    • 0028230678 scopus 로고
    • Distribution of agrin mRNAs in the chick embryo nervous system
    • (1994) J Neurosci , vol.14 , pp. 2943-2952
    • Ma1    Morgan2    Godfrey3
  • 114
    • 0028088813 scopus 로고
    • Building synapses: agrin and dystroglycan stick together
    • of outstanding interest, Review on the new possible roles of dystroglycan as a signaling receptor for agrin.
    • (1994) Trends Neurosci , vol.17 , pp. 469-473
    • Fallon1    Hall2
  • 115
    • 0028920977 scopus 로고
    • A motoneuron-selective stop signal in the synaptic protein s-laminin
    • (1995) Neuron , vol.14 , pp. 549-559
    • Porter1    Weis2    Sanes3
  • 116
    • 0028670787 scopus 로고
    • Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM
    • of special interest, Long-term potentiation in CA1 neurons of rat hippocampal slices is reduced by application of several L1 and NCAM antibodies, recombinant L1 fragments, and upon dissociation of the L1/NCAM complex through oligomannosidic carbohydrates and NCAM peptides. These results suggest that L1 and NCAM modulate the development or the stabilization of long-term potentiation.
    • (1994) Nature , vol.372 , pp. 777-779
    • Lüthl1    Laurent2    Figurov3    Muller4    Schachner5
  • 117
    • 0028968641 scopus 로고
    • Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains
    • of special interest, PSA—NCAM immunoreactivity is decreased in schizophrenic hippocampi and may suggest an altered plasticity of this structure. This is relevant to the neurodevelopmental hypothesis of schizophrenia.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2785-2789
    • Barbeau1    Liang2    Robitaille3    Quirion4    Srivastava5
  • 118
    • 0028902051 scopus 로고
    • Mutations in the cell adhesion molecule L1 cause mental retardation
    • of special interest, Review on L1 mutations or alteration of function that might lead to brain abnormalities resulting from disruption of mechanisms important in neural migration, axon guidance and axon—fascicule formation.
    • (1995) Trends Neurosci , vol.18 , pp. 168-172
    • Wong1    Kenwrick2    Willems3    Lemmon4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.