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1
-
-
0028909228
-
Regeneration of the auditory midbrain intercommissural projection in organotypic culture
-
(1995)
J Neurosci
, vol.15
, pp. 1298-1307
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-
Hafidi1
Sanes2
Hillman3
-
2
-
-
0028938453
-
Extensive regeneration in vitro by early embryonic neurons on immature and adult CNS tissue
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(1995)
J Neurosci
, vol.15
, pp. 2057-2062
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-
Shewan1
Berry2
Cohen3
-
3
-
-
0028952435
-
Type-specific stabilization and target-dependent survival of regenerating ganglion cells in the retina of adult rats
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(1995)
J Neurosci
, vol.15
, pp. 1057-1079
-
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Thanos1
Mey2
-
4
-
-
0028878068
-
Functional synaptic connections made by regenerated retinal ganglion cell axons in the superior colliculus of adult hamsters.
-
of special interest, Responses to light in discrete areas of the visual field were recorded within the superficial laminae of the reinnervated superior colliculus. This study shows that regenerated retinal ganglion axon terminals make excitatory synapses with neurons of the superficial retino-recipient layers of the superior colliculus. In some cases, the input from a single retinal ganglion cell is sufficient to drive postsynaptic superior colliculus neurons to threshold for excitation, suggesting that convergence of inputs from regenerated retinal ganglion cell axons is not required for the activation of neurons from the superior colliculus in response to light.
-
(1995)
J Neurosci
, vol.15
, pp. 665-675
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-
Sauvé1
Sawai2
Rasminsky3
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6
-
-
0029013323
-
Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery
-
of special interest, Following aspirative bilateral lesions of the septohippocampal projection in adult rats, temporary NGF infusions prevented long-term neuronal loss of septal cholinergic neurons. Furthermore, when these NGF infusions were combined with grafting of embryonic hippocampal cells into the lesion cavity, partial hippocampal reinnervation was achieved, resulting in functional recovery on a simple task assessing habituation.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4621-4625
-
-
Tuszynski1
Gage2
-
7
-
-
0029564661
-
Axonal regeneration and limited functional recovery following hippocampal deafferentation.
-
of special interest, Adult rats received unilateral lesion of the fimbria—fornix pathway and grafts of primary fibroblasts genetically modified to produce NGF. The data show that these NGF-producing grafts allow axotomized septal cholinergic neurons to reinnervate the hippocampus and result in functional recovery on a simple task assessing habituation, but not on a more complex spatial memory task, such as the Morris water maze.
-
(1995)
J Comp Neurol
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-
Eagle1
Chalmers2
Clary3
Gage4
-
8
-
-
0026236554
-
Facilitatory and inhibitory effects of glial cells and extracellular matrix in axonal regeneration
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(1991)
Curr Opin Neurobiol
, vol.1
, pp. 407-413
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Carbonetto1
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9
-
-
0027314268
-
Molecular profile of reactive astrocytes — implications for their role in neurological disease
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(1993)
Neuroscience
, vol.54
, pp. 15-36
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-
Eddleston1
Mucke2
-
10
-
-
0027343618
-
Reactive glia as rivals in regulating neuronal survival
-
(1993)
Glia
, vol.7
, pp. 102-110
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-
Giulian1
-
12
-
-
0028815823
-
Neuron saving schemes
-
(1995)
Nature
, vol.373
, pp. 289-290
-
-
Lindsay1
-
14
-
-
0027972545
-
Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon.
-
(1994)
J Neurosci
, vol.14
, pp. 335-347
-
-
Hyman1
Juhasz2
Jackson3
Wright4
Ip5
Lindsay6
-
17
-
-
0028339815
-
Neurotrophin-4 selectively promotes survival of striatal neurons in organotypic slice culture
-
(1994)
Brain Res
, vol.647
, pp. 340-344
-
-
Ardelt1
Flaris2
Roth3
-
18
-
-
0028206303
-
Neurotrophin-4/5 (NT-4/5) increases adult rat retinal ganglion cell survival and neurite outgrowth in vitro
-
(1994)
J Neurobiol
, vol.25
, pp. 953-959
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-
Cohen1
Bray2
Aguayo3
-
20
-
-
0027195615
-
The neurotrophic factor concept: a reexamination
-
(1993)
J Neurosci
, vol.13
, pp. 2739-2748
-
-
Korsching1
-
22
-
-
0028063908
-
Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors
-
(1994)
Curr Opin Neurobiol
, vol.4
, pp. 78-86
-
-
Baird1
-
23
-
-
0028172053
-
Transforming growth factor-β promotes survival of midbrain dopaminergic neurons and protects them against N-methyl-4-phenylpyridinium ion toxicity
-
(1994)
Neuroscience
, vol.63
, pp. 1189-1196
-
-
Krieglstein1
Unsicker2
-
25
-
-
0028795044
-
Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
-
of special interest, GDNF promotes the survival of dopaminergic neurons of substantia nigra in an adult rat model of axotomy by transection of the medial forebrain bundle. Daily intracerebral injections of rat recombinant GDNF allowed survival of more than 80% of dopaminergic neurons.
-
(1995)
Nature
, vol.373
, pp. 339-341
-
-
Beck1
Valverde2
Alexi3
Poulsen4
Moffat5
Vandlen6
Rosenthal7
Hefti8
-
26
-
-
0028874203
-
GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo
-
(1995)
Brain Res
, vol.672
, pp. 104-111
-
-
Kearns1
Gash2
-
27
-
-
0028834063
-
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
-
of outstanding interest, In vivo effect of GDNF is investigated in the nigrostriatal system of the adult mouse after MPTP lesion. Intracerebral injections of GDNF in the striatum or the substantia nigra rescue the mesencephalic dopaminergic neurons. Dopamine levels and motor behavior are restored after GDNF administration. These results suggest that GDNF may be a potent therapeutic agent for the treatment of Parkinson's disease.
-
(1995)
Nature
, vol.373
, pp. 335-339
-
-
Tomac1
Lindqvist2
Lin3
Ögren4
Young5
Hoffer6
Olson7
-
28
-
-
0028109717
-
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
-
of special interest, GDNF treatment supports the survival of rat motoneurons both in vitro and in vivo. The protective effects of GDNF are compared with those of NGF and BDNF on both motoneurons and PNS neurons. This study suggests that GDNF is a good candidate for the treatment of motoneuron disease.
-
(1994)
Science
, vol.266
, pp. 1062-1064
-
-
Henderson1
Phillips2
Pollock3
Davies4
Lemeulle5
Armanini6
Simpson7
Moffet8
Vandlen9
Koliatsos10
Rosenthal11
-
29
-
-
0028874195
-
Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
-
of special interest, GDNF rescues developing chick or mouse motoneurons from axotomy-induced and naturally programmed cell death in vivo, and promotes the survival cultured motoneurons. These data suggest that GDNF, either alone or associated with other neurotrophic factors, may be used in the treatment of amyotrophic lateral sclerosis and spinal muscular atrophy.
-
(1995)
Nature
, vol.373
, pp. 344-346
-
-
Oppenheim1
Houenou2
Johnson3
Lin4
Li5
Lo6
Newsome7
Prevette8
Wang9
-
30
-
-
0028854836
-
In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons
-
of special interest, GDNF exerts neurotrophic effects in vivo on neonatal and adult rat facial motoneurons. GDNF is retrogradely transported by neonatal spinal motoneurons. Local application of GDNF to the transected facial nerve prevents motoneuronal cell death and atrophy occurring after axotomy in the neonatal period. In adulthood, local or systemic applications of GDNF attenuate the decrease of choline acetyltransferase immunostaining in the facial nucleus. Thus, GDNF exerts an important neurotrophic influence on developing and adult motoneurons in vivo.
-
(1995)
Nature
, vol.373
, pp. 341-344
-
-
Yan1
Matheson2
Lopez3
-
31
-
-
0028061313
-
Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
-
of outstanding interest, This study showed that netrin-1 and netrin-2, two axonal outgrowth promoting proteins (see [33]), have a differential mRNA expression: netrin-1 mRNA is confined to floor plate cells, whereas netrin-2 is detected at lower levels in the ventral two-thirds of the spinal cord. Most importantly, the two netrin proteins exist in a diffusible form and could together establish a long-range gradient of tropic activity, guiding commissural axonal growth to the ventral midline of the spinal cord.
-
(1994)
Cell
, vol.12
, pp. 425-435
-
-
Kennedy1
Serafini2
De la Torre3
Tessier-Lavigne4
-
32
-
-
0029065329
-
The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
-
of outstanding interest, The results of this study suggest that diffusible netrin-1 is a bifunctional guidance cue that attracts a group of ventrally directed axons while steering away trochlear motor axons that grow dorsally from the floor plate.
-
(1995)
Cell
, vol.81
, pp. 621-629
-
-
Colamarino1
Tessier-Lavigne2
-
33
-
-
0028138219
-
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
-
of outstanding interest, Purification from embryonic chick brain of two proteins, netrin-1 and netrin-2, and identification of a distinct activity that potentiates the outgrowth-promoting activity of the netrins in the rat commissural axons of the developing spinal cord.
-
(1994)
Cell
, vol.78
, pp. 409-424
-
-
Serafini1
Kennedy2
Galko3
Mirzayan4
Jessell5
Tessier-Lavigne6
-
35
-
-
0029037182
-
Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
-
of special interest, Semaphorin III/collapsin is a diffusible guidance molecule expressed by ventral spinal cord cells. Semaphorin III is able to pattern sensory projections by selectively repelling small diameter afferents subserving pain and temperature that are NGF responsive and normally terminate in the dorsal spinal cord.
-
(1995)
Neuron
, vol.14
, pp. 949-959
-
-
Messersmith1
Leonardo2
Shatz3
Tessier-Lavigne4
Goodman5
Kolodkin6
-
36
-
-
0029054199
-
Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension
-
(1995)
Neuron
, vol.14
, pp. 941-948
-
-
Püschel1
Adams2
Betz3
-
37
-
-
0028804689
-
Localized collapsing cues can steer growth cones without inducing their full collapse
-
of outstanding interest, Exposure of growth cones, from temporal retinal and dorsal root ganglion cells, to collapsing stimuli (such as the motility-inhibiting protein collapsin) frequently results in smooth turning of growth cones away from the stimuli, without inducing their full collapse. The results suggest that inhibitory guidance cues can steer growth cones through a localized inhibition of lamellipodial protrusion.
-
(1995)
Neuron
, vol.14
, pp. 263-274
-
-
Fan1
Raper2
-
38
-
-
0028219210
-
Turning of nerve growth cones induced by neurotransmitters
-
2+ may act as a second messenger in the cytoplasm of the growth cone to initiate the turning response.
-
(1994)
Nature
, vol.368
, pp. 140-144
-
-
Zheng1
Felder2
Connor3
Poo4
-
39
-
-
0028984150
-
2+)-calmodulin signaling in Drosophila growth cones leads to stalls in axon extension and errors in axon guidance
-
(1995)
Neuron
, vol.14
, pp. 43-56
-
-
VanBerkum1
Goodman2
-
40
-
-
0028817332
-
A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth
-
of outstanding interest, The results show that a soluble chimeric form of the CAM L1 stimulates neurite outgrowth via the signal transduction cascade trigger by activation of the FGFR, in a similar if not identical manner then when initiated by membrane-bound L1. This paper raises an important issue about the ability of CAMs to promote neurite outgrowth independently of their function as substrate-associated adhesion molecules.
-
(1995)
Neuron
, vol.14
, pp. 57-66
-
-
Doherty1
Williams2
Walsh3
-
41
-
-
0028170989
-
2+ influx and neurite growth in response to purified N-cadherin and laminin
-
2+ in neuronal cell bodies and growth cones, and a decrease in glial cells.
-
(1994)
J Cell Biol
, vol.127
, pp. 1461-1475
-
-
Bixby1
Grunwald2
Bookman3
-
42
-
-
0028170211
-
Ectopic expression of connectin reveals a repulsive function during growth cone guidance and synapse formation
-
of special interest, Connectin seems to function as an attractive signal when coupled to its ability to mediate homophilic interactions between lateral embryonic muscles and SNa (segmental nerve a) motoneurons. In contrast, when connectin is expressed ectopically on ventral muscle, growth cones of SNb (segmental nerve b) motoneurons that normally innervate this target turn away from the connectin source, preventing synapse formation. These results suggest a repulsive function for connectin during motoneuron growth cone guidance and synapse formation.
-
(1994)
Neuron
, vol.13
, pp. 525-539
-
-
Nose1
Takeichi2
Goodman3
-
43
-
-
0028872784
-
Laminin and fibronectin guide-posts signal sustained but opposite effects to passing growth cones
-
of special interest, Growth cone velocity, well beyond the time of contact, is increased by laminin and decreased by fibronectin on model guideposts. In addition, laminin provides unambiguous directional guidance information to the advancing growth cone. These laminin-evoked growth cone responses require activation of protein kinase C dependent intracellular signalling mechanisms.
-
(1995)
Neuron
, vol.14
, pp. 275-285
-
-
Kuhn1
Schmidt2
Kater3
-
46
-
-
0028103938
-
Isolation of a neural chondroitin sulfate proteoglycan with neurite outgrowth promoting properties
-
of special interest, A novel proteoglycan, DSD-1-PG, is purified from postnatal mouse brain extract. DSD-1-PG promotes neurite outgrowth of rat embryonic mesencephalic and hippocampal neurons.
-
(1994)
J Cell Biol
, vol.126
, pp. 783-799
-
-
Faissner1
Clement2
Lochter3
Streit4
Mandl5
Schachner6
-
47
-
-
0028053871
-
T-Cadherin expression delineates specific regions of the developing motor axon-hindlimb projection pathway
-
(1994)
J Neurosci
, vol.14
, pp. 7331-7346
-
-
Fredette1
Ranscht2
-
48
-
-
0028109072
-
N-cadherin and Ng-CAM/8D9 are involved serially in the migration of newly generated neurons into the adult songbird brain
-
(1994)
Neuron
, vol.13
, pp. 567-582
-
-
Barami1
Kirschenbaum2
Lemmon3
Goldman4
-
50
-
-
0027955570
-
Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning
-
of special interest, NCAM-deficient mice appear healthy and fertile, and their motor abilities seem normal. However, they show a 10% reduction in overall brain weight, a 36% decrease in size of the olfactory bulb, and their spatial learning, as tested in the Morris water maze, is impaired. NCAM deficiency coincides with almost a total loss of PSA.
-
(1994)
Nature
, vol.367
, pp. 455-459
-
-
Cremer1
Lange2
Christoph3
Plomann4
Vopper5
Roes6
Brown7
Baldwin8
Kraemer9
Scheff10
-
51
-
-
0028067597
-
N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid
-
of outstanding interest, NCAM mutation in mice and the injection of endoneuraminidase, destroying the PSA moiety associated with NCAM, produce an accumulation of precursors in the subependymal layer, probably due to a decrease in rostral migration of olfactory precursors. Radial migration of granule cells in the olfactory bulb is not affected by PSA removal. Therefore, PSA on NCAM-180 seems to play a key role in tangential cell migration of olfactory precursors in the subependymal layer of the rat.
-
(1994)
Neuron
, vol.13
, pp. 595-609
-
-
Ono1
Tomasiewicz2
Magnuson3
Rutishauser4
-
52
-
-
0028133485
-
Polysialic acid regulates growth cone behavior during sorting of motor axons in the plexus region
-
of outstanding interest, Evidence for the permissive role of PSA on NCAM for axonal sorting by attenuating axon—axon fasciculation mediated by L1.
-
(1994)
Neuron
, vol.13
, pp. 405-414
-
-
Tang1
Rutishauser2
Landmesser3
-
53
-
-
0028832897
-
Embryonic (PSA) N-CAM reveals chains of migrating neuroblasts between the lateral ventricle and the olfactory bulb of adult mice
-
of special interest, The immunoreactivity of PSA—NCAM precisely reveals the migratory pathway of subventricular zone cells to the core of the olfactory bulb in adult mice. The cell—cell arrangement of PSA—NCAM-positive cells suggests an important role for this molecule in migration of neuronal precursors and new models for mechanisms involved in tangential migration.
-
(1995)
J Comp Neurol
, vol.351
, pp. 51-61
-
-
Rousselot1
Lois2
Alvarez-Buylla3
-
54
-
-
0028029162
-
Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM and N-cadherin
-
of outstanding interest, The neurite outgrowth stimulated by L1, NCAM and NCad implicates the activation of the FGFR and its second-messenger pathway. Furthermore, the authors identified a CAM homology domain in the FGF family of receptors that, once bound by specific antibodies, inhibits neurite outgrowth stimulated by L1, NCAM and NCad. Synthetic peptides derived from this domain can differentially and specifically inhibit neurite outgrowth stimulated by the above CAMs. In addition, a soluble L1—Fc chimera increases phosphotyrosine production on the same set of neuronal proteins that are phosphorylated following activation of the FGFR with bFGF.
-
(1994)
Neuron
, vol.13
, pp. 583-594
-
-
Williams1
Furness2
Walsh3
Doherty4
-
57
-
-
0028204441
-
Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum
-
of special interest, The loss of NCAM—NCAM-stimulated axonal growth during development could be due to the insertion of 10 amino acids (called VASE) to the fourth immunoglobulin domain of NCAM. The authors suggest that the presence of the VASE sequence, even in a minority of NCAM receptors, can inhibit the neurite outgrowth response, possibly by preventing NCAM from binding to the FGFR in the plasma membrane.
-
(1994)
J Cell Biol
, vol.125
, pp. 427-436
-
-
Saffell1
Walsh2
Doherty3
-
59
-
-
0028147879
-
Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance
-
of special interest, In Drosophila, increased levels of Fasciclin II in motoneuron growth cones and axons, and ectopic Fasciclin II expression on other cells encountered by the motoneurons alter growth cone guidance. The failure of these motoneurons to defasciculate might prevent them from responding to other guidance cues important for providing adequate innervation of the target area. In addition, this study shows that motoneurons can be diverted onto abnormal pathways by contact with Fasciclin II-positive cells in their environment.
-
(1994)
Neuron
, vol.13
, pp. 507-523
-
-
Lin1
Goodman2
-
60
-
-
0028346526
-
Decrease in growth cone-neurite fasciculation by sensory or motor cells in vitro accompanies downregulation of Aplysia cell adhesion molecules by neurotransmitters
-
of special interest, The neuropeptides Phe-Met-Arg-Phe-amide (FMRFamide) and serotonin downregulate the expression of NCAM-like molecules in Aplysia (apCAM) on motor and sensory cells, respectively. The downregulation of apCAM leads to a significant reduction in fasciculation of growth cones with other neurites extending from homologous cells, and is mimicked by treatment with antibodies against apCAM.
-
(1994)
J Neurosci
, vol.14
, pp. 1413-1421
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-
Peter1
Aronoff2
Wu3
Schacher4
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61
-
-
0028150965
-
Aplysia cell adhesion molecules and serotonin regulate sensory cell-motor cell interactions during early stages of synapse formation in vitro
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(1994)
J Neurosci
, vol.14
, pp. 6886-6900
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-
Zhu1
Wu2
Schacher3
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62
-
-
0028220181
-
Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor
-
(1994)
Neuron
, vol.12
, pp. 861-872
-
-
Taira1
Takaha2
Taniura3
Kim4
Miki5
-
66
-
-
0028216755
-
Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)
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(1994)
J Biol Chem
, vol.269
, pp. 12999-13004
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Raulo1
Chernousov2
Carey3
Nolo4
Rauvala5
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69
-
-
0028895717
-
Absence of persistent spreading, branching, and adhesion in GAP-43-depleted growth cones
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(1995)
J Cell Biol
, vol.128
, pp. 647-660
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Aigner1
Caroni2
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70
-
-
0028953495
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Growth cone advance is inversely proportional to retrograde F-actin flow
-
(1995)
Neuron
, vol.14
, pp. 763-771
-
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Lin1
Forscher2
-
71
-
-
0028316882
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Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability
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(1994)
J Cell Sci
, vol.107
, pp. 869-879
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Esmaeli-Azad1
McCarty2
Feinstein3
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72
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-
0343858564
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Adhesive molecules of the cell surface and extracellular matrix in neural regeneration
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A Gorio, Raven Press, Ltd, New York
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(1993)
Neuroregeneration
, pp. 77-100
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Carbonetto1
David2
-
73
-
-
0027440463
-
Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system
-
(1993)
Neurosci Res
, vol.17
, pp. 265-290
-
-
Seki1
Arai2
-
74
-
-
0028088417
-
A role for polysialylated neural cell adhesion molecule in lesion-induced sprouting in hippocampal organotypic cultures
-
of outstanding interest, The sprouting reaction triggered by a section of CA3—CA1 connections in hippocampal organotypic cultures is associated with the expression of PSA—NCAM on growing neurites. The enzymatic removal of PSA on NCAM significantly delays the sprouting reaction, suggesting the functional importance of PSA in this model.
-
(1994)
Neuroscience
, vol.61
, pp. 441-445
-
-
Muller1
Stoppini2
Wang3
Kiss4
-
75
-
-
0028346465
-
Embryonic neural cell adhesion molecule (N-CAM) is elevated in the denervated rat dentate gyrus
-
of special interest, Following entorhinal cortex lesion, the expression of PSA—NCAM is upregulated on the surface of dendrites in the denervated zone and on sprouting axons. Interestingly, as reinnervation of the proximal dendritic field of the outer molecular layer is completed by the sprouting of commissural and associational afferents, PSA—NCAM expression returns to normal levels. However, the remaining part of the outer molecular layer, which is reinnervated by other afferents, maintains high expression of PSA—NCAM. These findings suggest that PSA—NCAM is important in the dendritic response to sprouting and synaptic remodeling, and that the source of reinnervating axons determines the response of the dendritic membrane of the target neurons.
-
(1994)
J Neurosci
, vol.14
, pp. 4217-4225
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-
Miller1
Styren2
Lagenaur3
DeKosky4
-
76
-
-
0028151427
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Rapid expression and transport of embryonic N-CAM in the dentate gyrus following entorhinal cortex lesion: ultrastructural analysis
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(1994)
J Comp Neurol
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, pp. 486-492
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-
Styren1
Lagenaur2
Miller3
DeKosky4
-
77
-
-
0028916593
-
Alternate strategies in lesion-induced reactive synaptogenesis: differential expression of L1 in two populations of sprouting axons
-
of special interest, Temporal and spatial expressions of PSA—NCAM and L1 in the denervated zone following entorhinal cortex lesions are distinct. Shortly after entorhinal cortex lesions, L1 immunostaining declined in the outer molecular layer. Over 30 days post-lesion, L1 is expressed by sprouting commissural and associational afferents from the inner molecular layer. As L1-positive axons reinnervated this zone, PSA—NCAM staining appeared to recede. These changes in CAMs expression paralleled the known sequence of reactive synaptogenesis and axonal sprouting.
-
(1995)
Exp Neurol
, vol.131
, pp. 165-173
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-
Styren1
Miller2
Lagenaur3
DeKosky4
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78
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0026538276
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The embryonic form of neural cell surface molecule (E-NCAM) in the rat hippocampus and its reexpression following kainic acid-induced status epilepticus
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(1992)
J Neurosci
, vol.12
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Le Gal La Salle1
Rougon2
Valin3
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79
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Reactive astrocytes involved in the formation of lesional scars differ in the mediobasal hypothalamus and in other forebrain regions
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(1993)
J Neurosci Res
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Alonso1
Privat2
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80
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0028927456
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Molecular characterization of eukaryotic polysialyltransferase-1
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of outstanding interest, Cloning of the key enzyme, polysialyltransferase-1, responsible for PSA synthesis on NCAM. In reconstitution experiments, the enzyme induces PSA synthesis in all NCAM-expressing cell lines, providing evidence that a single enzymatic activity is required. The characterization of this enzyme gives new basis for studying the role of PSA in several fields of interest, including regeneration of the CNS.
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(1995)
Nature
, vol.373
, pp. 715-718
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Eckhardt1
Mühlenhoff2
Bethe3
Koopman4
Frosch5
Gerardy-Schahn6
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81
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0027314268
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Molecular profile of reactive astrocytes — implications for their role in neurological disease
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(1993)
Neuroscience
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Eddleston1
Mucke2
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83
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0027714683
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Contact inhibition in the failure of mammalian CNS axonal regeneration
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(1993)
Bioessays
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Johnson1
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90
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0027213847
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Sprouting and regeneration of lesioned corticospinal tract fibres in the adult rat spinal cord
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(1993)
Eur J Neurosci
, vol.5
, pp. 1156-1171
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Schnell1
Schwab2
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95
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0026585924
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Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines
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(1992)
Brain Res
, vol.569
, pp. 14-25
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Yoshida1
Gage2
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98
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0028126824
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Relationship between injury-induced astrogliosis, laminin expression and axonal sprouting in the adult rat brain
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(1994)
J Neurocytol
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Stichel1
Müller2
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99
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0026345228
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Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor
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(1991)
Neuron
, vol.7
, pp. 1019-1030
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Kawaja1
Gage2
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101
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0029051425
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Neural cell adhesion molecule (N-CAM) inhibits astrocyte proliferation after injury to different regions of the adult rat brain
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of special interest, Following cortical, hippocampal and striatal lesions, the population of dividing astrocytes is significantly smaller after infusion of NCAM or NCAM-related molecules. The authors raise the hypothesis that, by reducing glial proliferation, NCAM or its peptides may help create a more suitable environment for neuronal regeneration.
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(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4323-4327
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Krushel1
Sporns2
Cunningham3
Crossin4
Edelman5
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103
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0028958946
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Induction of L1 mRNA in PC12 cells by NGF is modulated by cell—cell contact and does not require the high-affinity NGF receptor
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of special interest, In PC12 cells, one week exposure to NGF increases L1 mRNA levels by fourfold. The authors demonstrate that this regulation is independent of the high-affinity NGF receptor and is modulated by cell—cell contact but not cell—ECM interactions.
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(1995)
J Neurosci
, vol.15
, pp. 2504-2512
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Itoh1
Brackenbury2
Akeson3
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105
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0025984342
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Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes
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of special interest, TGF-β1, TGF-β2 and NGF induce neurite outgrowth by increasing the expression of L1 by immature cultured astrocytes. TGF-β1 and TGF-β2 decrease the expression of NCAM by immature astrocytes. These factors do not modify the expression of adhesion molecules by mature astrocytes. An autocrine regulation of recognition molecule expression by NGF and TGF-β may play a key role in regulation of neuron—glia interactions after CNS lesion.
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(1994)
The Journal of Cell Biology
, vol.115
, pp. 473-484
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Saad1
Constam2
Ortmann3
Moos4
Fontana5
Schachner6
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107
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0028963635
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Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro
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of special interest, In this study, the authors used antisense oligonucleotides to block APP expression. Oligonucleotides internalization was achieved by linking them to pAntp (the homeodomain of the Antennapedia trans-acting protein) that allows membrane translocation. The application of APP antisense oligonucleotides on cultured embryonic cortical neurons resulted in a marked decrease of APP synthesis and in the subsequent decrease in axon and dendrite outgrowth.
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(1995)
The Journal of Cell Biology
, vol.128
, pp. 919-927
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Alinquant1
Hantraye2
Mailleux3
Moya4
Bouillot5
Prochiantz6
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108
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0028136865
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Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension.
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of special interest, The sequence of five amino acids 328–332 of APP induces neurite extension through cell-surface binding.
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(1994)
J Neurosci
, vol.14
, pp. 5461-5470
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Jin1
Ninomiya2
Roch3
Schubert4
Masliah5
Otero6
Saitoh7
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112
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0028344867
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Localization and alternative splicing of agrin mRNA in adult rat brain: transcripts encoding isoforms that aggregate acetylcholine receptors are not restricted to cholinergic neurons
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of special interest, The level of expression and pattern of alternative splicing of agrin mRNA (agrin0, agrin8, agrin11, agrin19) are differentially regulated in the brain. Overall, agrin mRNA distribution in the adult brain is broad and predominantly neuronal, suggesting that agrin may play a role in the formation and maintenance of synapses between neurons in the CNS.
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(1994)
J Neurosci
, vol.14
, pp. 1141-1152
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O'Connor1
Lauterborn2
Gall3
Smith4
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114
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0028088813
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Building synapses: agrin and dystroglycan stick together
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of outstanding interest, Review on the new possible roles of dystroglycan as a signaling receptor for agrin.
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(1994)
Trends Neurosci
, vol.17
, pp. 469-473
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Fallon1
Hall2
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115
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0028920977
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A motoneuron-selective stop signal in the synaptic protein s-laminin
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(1995)
Neuron
, vol.14
, pp. 549-559
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Porter1
Weis2
Sanes3
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116
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0028670787
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Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM
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of special interest, Long-term potentiation in CA1 neurons of rat hippocampal slices is reduced by application of several L1 and NCAM antibodies, recombinant L1 fragments, and upon dissociation of the L1/NCAM complex through oligomannosidic carbohydrates and NCAM peptides. These results suggest that L1 and NCAM modulate the development or the stabilization of long-term potentiation.
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(1994)
Nature
, vol.372
, pp. 777-779
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Lüthl1
Laurent2
Figurov3
Muller4
Schachner5
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117
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0028968641
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Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains
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of special interest, PSA—NCAM immunoreactivity is decreased in schizophrenic hippocampi and may suggest an altered plasticity of this structure. This is relevant to the neurodevelopmental hypothesis of schizophrenia.
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(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2785-2789
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Barbeau1
Liang2
Robitaille3
Quirion4
Srivastava5
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118
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0028902051
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Mutations in the cell adhesion molecule L1 cause mental retardation
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of special interest, Review on L1 mutations or alteration of function that might lead to brain abnormalities resulting from disruption of mechanisms important in neural migration, axon guidance and axon—fascicule formation.
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(1995)
Trends Neurosci
, vol.18
, pp. 168-172
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Wong1
Kenwrick2
Willems3
Lemmon4
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