Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites

European Journal of Neuroscience

Volumn 7, Issue 11, 1995, Pages 2294-2300

  Göke, Rüdiger ^a   Larsen, Philip J ^b   Mikkelsen, Jens D ^b   Sheikh, Søren P ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

circumventricular organs; gut brain axis; receptor autoradiography

Indexed keywords

BINDING PROTEIN; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; IODINE 125; LIGAND; RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AREA POSTREMA; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; BIOCHEMISTRY; BRAIN; BRAIN CORTEX; BRAIN STEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS LINKING; HYPOTHALAMUS; INFERIOR OLIVE; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SEPTUM PELLUCIDUM; SOLITARY TRACT NUCLEUS; SUBFORNICAL ORGAN; TEGMENTUM; THALAMUS;

ANIMAL; AUTORADIOGRAPHY; BINDING SITES; BRAIN; KINETICS; MALE; PEPTIDE FRAGMENTS; PEPTIDES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR;

EID: 0028867442     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1995.tb00650.x     Document Type: Article

References (34)

1. Changes in the arterial blood pressure and heart rate induced by glucagon‐like peptide‐1(7–36) amide in rats
2. Role of the area postrema in vomiting and related functions
3. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein‐dye binding
4. Divergent tissue‐specific and developmental expression of receptors for glucagon and glucagon‐like peptide‐1 in the mouse
5. Central representation of visceral function
6. Proglucagon‐derived peptides: nomenclature, biosynthetic relationships and physiological roles
7. Relations between neuropeptides and gut hormones
8. Interaction of GLP‐1(7–36)amide and cholecystokinin‐8 in the endocrine and exocrine pancreas
9. The area postrema: a cardiovascular control centre at the blood‐brain interface
10. Receptors for glucagon‐like peptide‐1(7–36)amide on rat insulinoma‐derived cells
11. Characterization of the receptor for glucagon‐like peptide‐1 (7–36)amide on plasma membranes from rat insulinoma‐derived cells by covalent cross‐linking
12. Glucagon‐like peptide‐1(7–36)amide is a new incretin/enterogastrone candidate
13. Exendin‐4 is a high potency agonist and truncated exendin‐(9–39)‐amide an antagonist at the glucagon‐like peptide‐1‐(7–36)‐amide receptor of insulin secreting β‐cells
14. Solubilization of active receptors for glucagon‐like peptide‐1(7–36)amide from rat lung membranes
15. Cellular localization of proglucagon/glucagon‐like peptide 1 messenger RNAs in rat brain
16. Effect of intestinal inhibitory peptides on vagally induced secretion from isolated perfused porcine pancreas
17. Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclase
18. Distribution of glucagonlike peptide I (GLP‐1), glucagon, and glicentin in the rat brain: an immunocytochemical study
19. Sensory circumventricular organs and brain homeostatic pathways
20. Identification and characterization of glucagon‐like peptide‐1 7–36 amide‐binding sites in the rat brain and lung
21. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
22. 1 mRNA in forebrain areas of the rat central nervous system
23. Central catecholaminergic systems: anatomy and physiology of the norepinephrine and epinephrine systems
24. Peptides in brain and intestine
25. Characterization of receptors for glucagon‐like peptide‐1(7–36)amide on rat lung membranes
26. Pancreatic polypeptide: a hormone under vagal control
27. Identification and localization of glucagon‐like peptide‐1 and its receptor in rat brain
28. Neurons of the A1/A2 region in the guinea pig medulla oblongata containing glucagon, glicentin and dopamine β‐hydroxylase immuno‐reactivity
29. Species difference of glucagon‐like materials in the brain
30. Autoradiographic localization of receptors for glucagon‐like peptide‐1(7–36)amide in rat brain
31. Truncated GLP‐1 (proglucagon 78–107‐amide) from distal gut: role in regulation of gastric and pancreatic functions
32. A new twist in the brain‐gut axis
33. Central nervous system control of nutrient homeostasis