Optimization of Lyophilization Conditions for Recombinant Human Interleukin-2 by Dried-State Conformational Analysis Using Fourier-Transform Infrared Spectroscopy

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 12, Issue 9, 1995, Pages 1250-1259

  Prestrelski, Steven J ^a,b   Pikal, Katherine A ^a   Arakawa, Tsutomu ^a  

^a AMGEN INC   (United States)

^b ALZA CORPORATION   (United States)

Author keywords

infrared spectroscopy; interleukin 2; lyophilization; protein conformation; stability

Indexed keywords

RECOMBINANT INTERLEUKIN 2;

ARTICLE; CELL GROWTH; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; FOURIER TRANSFORMATION; FREEZE DRYING; HUMAN; HUMAN CELL; INFRARED SPECTROPHOTOMETRY; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE; STORAGE; T LYMPHOCYTE;

DRUG STABILITY; EVALUATION STUDIES; FREEZE DRYING; HUMAN; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-2; MOLECULAR WEIGHT; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; WATER;

EID: 0028865701     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1016296801447     Document Type: Article

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