Intrathymic injection of alloantigen may lead to hyperacute rejection and prolonged graft survival of heart allografts in the rat

Transplantation

Volumn 60, Issue 9, 1995, Pages 1061-1063

  de Bruin, Ron W F ^a   van Rossum, Tékla J ^a   Scheringa, Marcel ^b   Bonthuis, Fred ^a   IJzermans, Jan N M ^a   Marquet, Richard L ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BLOOD TRANSFUSION; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNIZATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SPLEEN CELL;

ACUTE DISEASE; ANIMAL; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; ISOANTIGENS; LYMPHOCYTE TRANSFUSION; MALE; RATS; RATS, INBRED BN; RATS, INBRED STRAINS; SPLEEN; THYMUS GLAND; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0028864816     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Posselt AM, Barker CD, Tomaszewski JE, Markmann JF, Choti MA, Naji A. Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science 1990; 249: 1293.
2. Odorico JS, Posselt AM, Naji A, Markmann JF, Barker CD. Promotion of rat cardiac allograft survival by intrathymic in-oculation of donor splenocytes. Transplantation 1993; 55: 1104.
3. de Bruin RWF, Bouwman E, Marquet RL, Jeekel J. Prevention of transfusion induced sensitisation by heating of donor blood. Transplant Proc 1989; 21: 1181.
4. Bouwman E, Heineman E, Ijzermans JNM, de Bruin RWF, Marquet RL, Jeekel J. The outcome of donor-specific blood transfusions is determined by the dendritic population in the graft. Transplant Proc 1986; 18: 690.
5. Ono K, Lindsey ES. Improved techniqe of heart transplantation in rats. J Thorac Cardiovasc Res 1969; 57: 225.
6. de Bruin RWF, Saat RE, Heineman E, Jeekel J, Marquet RL. Effects of donor pretreatment with antilymphocyte serum and cyclosporin on rejection and graft versus host disease after small bowel transplantation in immunosuppressed and non-immunosuppressed rats. Transplant Int 1992; 6: 22.
7. Ijzermans JNM, Bouwman E, de Bruin RWF, Jeekel J, Marquet RL. Increase of major histocompatibility complex class II positive cells in cardiac allografts by IFN-τ has no impact on graft survival. Transplantation 1989; 48: 1039.
8. Marquet RL, Heystek GA, van Leersum RH. The effect of anti donor serum and antigen-antibody complexes on the survival of heart allografts in rats presensitized with donor blood. Transplantation 1977; 23: 119.
9. Mohiuddin M, Kline G, Shen Z, Ruggiero V, Rostami S, DiSesa V. Experiments in cardiac xenotransplantation. Response to intrathymic xenogeneic cells and intravenous cobra venom factor. J Thorac Cardiovasc Surg 1993; 106: 632.