Arachidonic acid and eicosanoids as targets and effectors in second messenger interactions

Prostaglandins, Leukotrienes and Essential Fatty Acids

Volumn 53, Issue 4, 1995, Pages 239-254

  Di Marzo, V ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; ICOSANOID; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PROSTAGLANDIN;

HUMAN; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; ARACHIDONIC ACID; CALCIUM; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; DIGLYCERIDES; EICOSANOIDS; ENZYME ACTIVATION; GROWTH SUBSTANCES; HAMSTERS; HUMAN; INOSITOL PHOSPHATES; MODELS, BIOLOGICAL; PHOSPHOLIPASE D; PHOSPHORIC DIESTER HYDROLASES; PROTEIN KINASE C; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; SECOND MESSENGER SYSTEMS; SUPPORT, NON-U.S. GOV'T;

EID: 0028863120     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/0952-3278(95)90123-X     Document Type: Review

References (183)

1. Crosstalk among multiple signal-activated phospholipases
2. The interaction of cyclic nucleotides and calcium in the control of cellular activity
3. Interactions between the cAMP and calcium messenger systems
4. Calcium as intracellular messenger: from simplicity to complexity
5. Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship
6. Receptor classes and the transmitter-gated ion channels
7. Triggering signalling cascades by receptor tyrosine kinases
8. G proteins
9. Mechanisms of multifunctional signalling by G protein-linked receptors
10. Protein kinase C, calcium and phospholipid degradation
11. Signal integration at the level of protein kinases, protein phosphatases and their substrates
12. An enzymatic mechanism for potassium channel stimulation through pertussistoxin-sensitive G proteins
13. Phospholipase D in cell signalling and its relationship to phospholipase C
14. − and phospholipase C-metabolites
15. 2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers
16. Arachidonic acid and signal transduction
17. Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling
18. Receptor tyrosine kinases
19. Signal transduction system for growth factor receptors associated with tyrosine kinase activity: epidermal growth factor receptor signalling and its regulation
20. Receptor-coupled phospholipase D and its inhibition
21. New roles for G-protein βγ-dimers in transmembrane signalling
22. 2+-dependent translocation domain with homology to PKC and GAP
23. Immunological release of histamine and slow-reacting substance of anaphylaxis from human lung: IV. Enhancement by cholinergic and α-adrenergic stimulation
24. Neuropeptides and inflammatory mediators: bidirectional regulative mechanisms
25. The role of cyclic AMP in the inhibition of leukotriene biosynthesis by neuropeptides
26. Differential regulation of early phase and late phase responses in human neutrophils by cAMP
27. Multiple pathways for signal transduction in the regulation of arachidonic acid metabolism in rat peritoneal macrophages
28. Modulation of arachidonic acid metabolism and cyclic AMP content of human alveolar macrophages
29. 2 in an autocrine fashion
30. Leukotriene-D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchyma
31. 2+ ionophore-, antigen- and agonist-induced inositol phosphate release in rat basophilic leukaemia (RBL-1) cells
32. 2
33. Intracellular signaling in the regulation of renal Na-K-ATPase: II. Role of eicosanoids
34. 2
35. Inhibition by fatty acids of cyclic AMP-dependent protein kinase activity in brush border membranes isolated from human placental vescicles
36. Differential effect of arachidonic acid on the vasoactive intestinal peptide receptor/effector system in rat prostatic epithelium during sexual maturation
37. Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: II. A pathway involving arachidonic acid release, prostaglandin synthesis and cyclic AMP accumulation
38. Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: I. Involvement of protein kinase C-dependent and -independent pathways
39. A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release
40. 2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells
41. 2 receptor synergism
42. 2 receptor-dependent potentiation of arachidonic acid release
43. 2
44. 2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation
45. 2 α-subunit phosphorylation in intact hepatocytes
46. Phosducin is a protein kinase A-regulated G-protein regulator
47. Cyclic AMP regulation of annexins I, II, V synthesis and localization in cultured porcine thyroid cells
48. 2 dopamine receptors on arachidonic acid release and cAMP production in striatal neurons
49. 2+/calmodulin-dependent protein kinase II, cAMP-dependent protein kinase, and casein kinase II
50. Glutamate-evoked release of arachidonic acid from mouse brain astrocytes
51. Eclosion hormone stimulates cyclic GMP levels in Manduca sexta nervous tissue via arachidonic acid metabolism with little or no contribution from the production of nitric oxide
52. 1-adrenergic potentiation of vasoactive intestinal peptide- versus β-adrenergic-stimulated cyclic AMP and cyclic cGMP accumulation in rat pinealocytes
53. 2 activation, platelet activating factor generation and prostacyclin release in spontaneously beating rat cardiomyocytes
54. Modulation by protein kinase C of arachidonic acid release from permeabilised myometrial cells of guinea pig uterus
55. 2 release by cultured rabbit gastric epithelial cells
56. Platelet-activating factor-stimulated protein tyrosine phosphorylation and eicosanoid synthesis in rat kupffer cells
57. 2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue
58. 2+, AA metabolites and vasodilators
59. 2 in rabbit pulmonary arterial smooth muscle cells
60. 2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids
61. 2+-dependent translocation to membranes
62. 2 and protein kinase C enzymatic activities and their interactions in Hydra vulgaris
63. 2-stimulating protein regulated by protein kinase C in Aplysia neurons
64. 2 in Hydra tentacle regeneration
65. Arachidonic acid and the control of body pattern in Hydra
66. Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release — Role of protein kinase C
67. Growth-dependent changes in arachidonic acid release from endothelial cells are mediated by protein kinase-C and changes in diacylglycerol
68. Glucose-induced protein kinase-C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells
69. Role of protein kinase-C in bradykinin-induced prostaglandin formation in osteoblasts
70. 2 in bovine pulmonary artery endothelial cells
71. 2 activation in Madin-Darby canine kidney cells
72. 2 by bradykinin and 4β-phorbol 12-myristate 13-acetate — Evidence for a receptor-GTP-binding protein versus a protein kinase-C mediated mechanism
73. 2+-dependent and -independent pathways
74. 2)
75. Arachidonic acid release and inositol lipid metabolism in response to bradykinin and related peptides in human endometrial cells in vitro
76. Bradykinin stimulates arachidonic acid release through the sequential action of an sn-1 diacylglycerol lipase and a monoacylglycerol lipase
77. 2 is coupled to hormonally regulated release of arachidonic acid
78. 2
79. Inhibition of expression of protein kinase-C α by antisense cDNA inhibits phorbol ester-mediated arachidonate release
80. Calcium influx and protein kinase-C α activation mediate arachidonic acid mobilization by the human NK-2 receptor expressed in Chinese hamster ovary cells
81. Different roles of protein kinase C-β and C-δ in arachidonic acid cascade, superoxide formation and phosphoinositide hydrolysis
82. Possible regulatory functions of protein kinase C α and ε isoenzymes in rat renal mesangial cells
83. Annexin-5 as a potential regulator of annexin-1 phosphorylation by protein kinase C — In vitro inhibition compared with quantiative data on annexin distribution in human endothelial cells
84. Interactions of annexins with membrane phospholipids
85. Isolation of human brain protein kinase C: evidence for kinase C catalytic fragment modulating G protein-GTPase activity
86. 2α from the membrane to the cytosol in mouse mastocytoma P-815 cells
87. Stimulatory and inhibitory guanine nucleotide-binding regulatory protein involvement in stimulation of arachidonic acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea pig alveolar macrophages
88. 2 receptor by protein kinase C
89. 2 dopamine receptor cDNA
90. 4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells
91. Phorbol myristate acetate stimulates the formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human neutrophils by activating NADPH oxidase
92. 2
93. 2α production activating diacylglycerol lipase in Rana esculentia interrenal
94. Tumor necrosis factor-α stimulates phosphatidylinositol breakdown by phospholipase C to coordinately increase the levels of diacylglycerol, free arachidonic acid and prostaglandins in an osteoblast (MC3T3-E1) cell line
95. Effects of lysophospholipids and diacylglycerols on the transfer of arachidonic acid to phospholipids and triacylglycerols in rat brain membranes
96. 2 of ram spermatozoa
97. 2 and subsequent exocytosis in ram spermatozoa — Evidence that the effect is not mediated via protein kinase C
98. 2 activation in human platelets and neutrophils
99. 4 synthesis in human neutrophils: different effects of oleoylacetylglycerol and phorbol myristate acetate as priming agents
100. Role of fatty acids in signal transduction: modulators and messengers
101. Evidence that protein kinase-C α has reduced affinity towards 1,2-dioctanoyl-sn-glycerol — The effects of lipid activators on phorbol ester binding and kinase activity
102. Further identification of protein kinase-C isozymes in mouse epidermis
103. Characteristics of arachidonic acid-mediated brain protein kinase C activation — Evidence for concentration-dependent heterogeneity
104. Requirement for diacylglycerol and protein kinase C in HeLa Cell-substratum adhesion and their feedback amplification of arachidonic acid production for optimum cell spreading
105. PKC mediates 12(S)-HETE-induced cytoskeletal rearrangement in B16a melanoma cells
106. The lipoxygenase metabolite 12(S)-HETE induces a protein kinase C-dependent cytoskeletal rearrangement and retraction of microvascular endothelial cells
107. Protein kinase C-dependent effects of 12(S)-HETE on endothelial cell vitronectin receptor and fibronectin receptor
108. Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of α versus β integrin — A posttranscriptional, protein kinase C- and cytoskeleton-dependent process
109. 2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation
110. In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites
111. Activation of protein kinase C phosphorylation pathways: a role for storage of associative memory
112. Modulation of the β-adrenergic response of cardiomyocytes by specific lipoxygenase products involves their incorporation into phosphatidylinositol and activation of protein kinase C
113. Diacylglycerol kinase is stimulated by arachidonic acid in neural membranes.
114. Endothelin-1 receptor binding and cellular signal transduction in cultured human brain endothelial cells
115. 2+ increase and arachidonic acid release in FRTL-5 thyroid cells
116. −-stimulated release of inositol phosphates, diglycerides and arachidonic acid in MC3T3-E1 osteoblasts
117. 2 and phospholipase C signal-transduction pathways
118. 2-induced arachidonic acid release and catecholamine secretion from cultured bovine adrenal chromaffin cells
119. Dietary ω-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils
120. Transmembrane signaling in human polymorphonuclear neutrophils — 15(S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid modulates receptor agonist triggered cell activation
121. Novel second messenger interactions in rat basophilic leukaemia (RBL-1) cells
122. 2 can be resolved from phosphoinositidase-C in primary cultures of mouse osteoblasts using indomethacin
123. Role of arachidonic acid and glutamate in the formation of inositol phosphates induced by noradrenalin in striatal astrocytes
124. Control of inositol polyphosphate-mediated calcium mobilization by arachidonic acid in pancreatic acinar cells of rats
125. Importance of arachidonic acid metabolites in regulating ATP-induced calcium fluxes in thyroid FRTL-5 cells
126. Signalling properties of lysophosphatidic acid
127. Hepoxilins activate phospholipase D in the human neutrophil
128. 2α activates phospholipase D independently from activation of protein kinase C in osteoblast-like cells
129. In vitro activation and inhibition of rat colonic phospholipase D by fatty acids
130. 2 activation by phosphatidic acid endogenously formed through phospholipase D action in rat peritoneal mast cells
131. 2+ concentration in rat peritoneal mast cells
132. Phosphatidate-induced arachidonic acid mobilization in mouse peritoneal macrophages.
133. SCF/c-KIT receptor mediated arachidonic acid liberation in rat mast cells — Involvement of PLD activation associated tyrosine phosphorylation
134. Phospholipase D activity in phagocytic leucocytes is synergistically regulated by G-protein-based and tyrosine kinase-based mechanisms
135. Interferon-γ induces a phospholipase D-dependent release of arachidonic acid from endothelial cell membranes — A mechanism for protein kinase C activation
136. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
137. Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent
138. Anandamide, an endogenous cannabinomimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction
139. Formation and inactivation of endogenous cannabinoid anandamide in central neurons
140. N-Acylated glycerophospholipids and their derivatives
141. Catabolism of N-acylethanolamine phospholipids by dog brain preparations
142. 2 activation
143. 2 genes in embryonic mouse cells
144. 2
145. 2 by transforming growth factor-α in HEL-30 keratinocytes
146. Stimulation of arachidonic acid release from Swiss 3T3 cells by recombinant basic fibroblast growth factor — Independence from phosphoinositide turnover
147. Regulation of eicosanoid biosynthesis in the macrophage — Involvement of protein tyrosine phosphorylation and modulation by selective protein tyrosine kinase inhibitors
148. 2+ and the release of arachidonic acid and prostaglandins in NIH 3T3 fibroblasts
149. Over-expression of protein kinase C α enhances platelet-derived growth factor-induced and phorbol ester-induced but not calcium ionophore-induced formation of prostaglandins in NIH 3T3 fibroblasts
150. 2 is phosphorylated and activated by MAP kinase
151. 2 by p42 microtubule-associated protein-2 kinase and protein kinase C
152. 2+ and mitogen-activated protein kinase regulation
153. Ras is required for epidermal growth factor-stimulated arachidonic acid release in rat-1 fibroblasts
154. 2 in glomerular mesangial cells
155. Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells
156. Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells
157. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue.
158. Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells
159. Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cycloxygenase products
160. 12(S)-Hydroxyeicosatetraenoic acid regulates DNA synthesis and protooncogene expression induced by epidermal growth factor and insulin in rat lens epithelium
161. Suppression of platelet-derived growth factor receptor tyrosine kinase activity by unsaturated fatty acids
162. Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells
163. The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid.
164. Function of ras as a molecular switch in signal transduction
165. Effects of prostaglandins and hydroxyoctadecadienoic acid on epidermal growth factor-dependent DNA synthesis and c-myc protooncogene expression in Syrian hamster embryo cells
166. Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.
167. 2+ mobilization, by cyclic AMP and GMP in rabbit aortic smooth muscle cells
168. Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-α in normal human skin fibroblasts and keratinocytes
169. 2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis
170. Angiotensin II stimulates the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells
171. Guinea pig histamine H-1 receptor: 2. Stable expression in Chinese hamster ovary cells reveals the interaction with three major signal transduction pathways
172. 2-induced arachidonic acid release in osteoblast-like cells: independence from phosphoinositide hydrolysis
173. UTP activates multiple 2nd messenger systems in cultured rat astrocytes
174. 2
175. Covalent binding of arachidonate to G protein a subunits of human platelets
176. Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway
177. Selective incorporation of 15-HETE in phosphatidylinositol: agonist-induced deacylation and transformation of stored HETEs by human neutrophils
178. Regulation of guanine — nucleotide binding proteins in islet subcellular fractions by phospholipase-derived lipid mediators of insulin secretion
179. Modulation of ion channels by arachidonic acid
180. Interactions among cell signalling systems