Studies in subjects with long-term nonprogressive human immunodeficiency virus infection

New England Journal of Medicine

Volumn 332, Issue 4, 1995, Pages 209-216

  Pantaleo, Giuseppe ^a   Menzo, Stefano ^a   Vaccarezza, Mauro ^a   Graziosi, Cecilia ^a   Cohen, Oren J ^a   Demarest, James F ^a   Fauci, Anthony S ^a   Zhao, Xue Qiao ^a   Schrager, Lewis K ^b   Giorgi, Janis V ^c   Montefiori, David ^d   Orenstein, Jan M ^e   Fox, Cecil ^f   Margolick, Joseph B ^g   Buchbinder, Susan ^h  

^a Laboratory of Immunoregulation ^*  (United States)

^b Division of AIDS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e GEORGE WASHINGTON UNIVERSITY   (United States)

^f Molecular Histology Labs   (United States)

^g JOHNS HOPKINS UNIVERSITY   (United States)

^h University School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; NEUTRALIZING ANTIBODY; VIRUS DNA; VIRUS RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LEUKOCYTE COUNT; LYMPH NODE BIOPSY; MALE; PRIORITY JOURNAL; VIRUS ISOLATION; VIRUS REPLICATION;

ADULT; CD4 LYMPHOCYTE COUNT; COMPARATIVE STUDY; DISEASE PROGRESSION; FEMALE; HIV ANTIBODIES; HIV INFECTIONS; HIV SEROPOSITIVITY; HIV-1; HUMAN; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; MALE; MIDDLE AGE; RNA, VIRAL; SUPPORT, U.S. GOV'T, P.H.S.; VIREMIA;

EID: 0028861377     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199501263320402     Document Type: Article

References (35)

1. Pantaleo G, Graziosi C, Fauci AS The immunopathogenesis of human immunodeficiency virus infection. N Engl J Med 1993; 328: 327-335
2. Clark SJ, Saag MS, Decker WD, High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection. N Engl J Med 1991; 324: 954-960
3. Daar ES, Moudgil T, Meyer RD, Ho DD Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 1991; 324: 961-964
4. Safrit JT, Andrews CA, Zhu T, Ho DD, Koup RA Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope. J Exp Med 1994; 179: 463-472
5. Reimann KA, Tenner-Racz K, Racz P, Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. J Virol 1994; 68: 2362-2370
6. Pantaleo G, Demarest JF, Soudeyns H, Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV. Nature 1994; 370: 463-467
7. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MB Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 1994; 68: 6103-6110
8. Graziosi C, Pantaleo G, Butini L, Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection. Proc Natl Acad Sci U S A 1993; 90: 6405-6409
9. Fauci AS, Schnittman SM, Poli G, Koenig S, Pantaleo G Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection. Ann Intern Med 1991; 114: 678-693
10. Lifson AR, Buchbinder SP, Sheppard HW, Long-term human immunodeficiency virus infection in asymptomatic homosexual and bisexual men with normal CD4+ lymphocyte counts: immunologic and virologic characteristics. J Infect Dis 1991; 163: 959-965
11. Buchbinder SP, Katz MH, Hessol NA, O'Malley PM, Holmberg SD Long-term HIV-1 infection without immunologic progression. AIDS 1994; 8: 1123-1128
12. Sheppard HW, Lang W, Ascher MS, Vittinghoff E, Winkelstein W The characterization of non-progressors: long-term HIV-1 infection with stable CD4+ T-cell levels. AIDS 1993; 7: 1159-1166
13. Levy JA HIV pathogenesis and long-term survival. AIDS 1993; 7: 1401-1410
14. Easterbrook PJ Non-progression in HIV infection. AIDS 1994; 8: 1179-1182
15. Schrager LK, Young JM, Fowler MG, Mathieson BJ, Vermund SH Long-term survivors of HIV-1 infection: definitions and research challenges. AIDS 1994; 8: Suppl: S95-S108
16. Pantaleo G, Graziosi C, Butini L, Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci U S A 1991; 88: 9838-9842
17. Pantaleo G, Graziosi C, Demarest JF, HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993; 362: 355-358
18. Menzo S, Bagnarelli P, Giacca M, Manzin A, Varaldo PE, Clementi M Absolute quantitation of viremia in human immunodeficiency virus infection by competitive reverse transcription and polymerase chain reaction. J Clin Microbiol 1992; 30: 1752-1757
19. Bagnarelli P, Menzo S, Valenza A, Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS. J Virol 1992; 66: 7328-7335
20. Fox CH, Tenner-Racz K, Racz P, Firpo A, Pizzo PA, Fauci AS Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA. J Infect Dis 1991; 164: 1051-1057
21. Montefiori DC, Robinson WE Jr, Schuffman SS, Mitchell WM Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay. J Clin Microbiol 1988; 26: 231-235
22. Pantaleo G, DeMaria A, Koenig S, CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity. Proc Natl Acad Sci U S A 1990; 87: 4818-4822
23. Burke AP, Anderson D, Mannan P, Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome. Hum Pathol 1994; 25: 248-256
24. Biberfeld P, Ost A, Porwit A, Histopathology and immunohistology of HTLV-III/LAV related lymphadenopathy and AIDS. Acta Pathol Microbiol Immunol Scand Suppl 1987; 95: 47-65
25. Armstrong JA. Ultrastructure and significance of the lymphoid tissue lesions in HIV infection. In: Racz P, Dijkstra CD, Gluckman J-C, eds. Accessory cells in HIV and other retroviral infections: morphological and functional aspects. Basel, Switzerland: Karger, 1991:69-82.
26. Tenner-Racz K, Racz P, Dietrich M, Karin P Altered follicular dendritic cells and virus-like particles in AIDS and AIDS-related lymphadenopathy. Lancet 1985; 1: 105-106
27. Embretson J, Zupancic M, Ribas JL, Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 1993; 362: 359-362
28. Armstrong JA, Dawkins RL, Horne R Retroviral infection of accessory cells and the immunological paradox in AIDS. Immunol Today 1985; 6: 121-122
29. Emilie D, Peuchmaur M, Maillot M, Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes. J Clin Invest 1990; 86: 148-159
30. Spiegel H, Herbst H, Niedobitek G, Foss HD, Stein H Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells. Am J Pathol 1992; 140: 15-22
31. Tenner-Racz K, Racz P, Bofill M, HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS. Am J Pathol 1986; 123: 9-15
32. Shioda T, Levy JA, Cheng-Mayer C Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene. Nature 1991; 349: 167-169
33. Westervelt P, Gendelman HE, Ratner L Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes. Proc Natl Acad Sci U S A 1991; 88: 3097-3101
34. Donaldson YK, Bell JE, Holmes EC, Sughes ES, Brown HK, Simmonds P In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop. J Virol 1994; 68: 5991-6005
35. Zhu T, Mo H, Wang N, Genotypic and phenotypic characterization of HIV-1 in patients with primary infection. Science 1993; 261: 1179-1181