Role of nitric oxide in parasitic infections

Microbiological Reviews

Volumn 59, Issue 4, 1995, Pages 533-547

  James, Stephanie L ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b Solar Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; NITRIC OXIDE;

BRAIN MALARIA; CANCER; HUMAN; LEISHMANIASIS; NONHUMAN; PARASITOSIS; PATHOPHYSIOLOGY; REVIEW; SCHISTOSOMIASIS; SIGNAL TRANSDUCTION; TOXOPLASMOSIS; TRYPANOSOMIASIS;

ANIMALIA; PROTOZOA; VERMES;

EID: 0028853663     PISSN: 01460749     EISSN: None     Source Type: Journal    
DOI: 10.1128/mmbr.59.4.533-547.1995     Document Type: Review

References (204)

1. Adams, L. B., J. B. Hibbs, Jr., R. K. Taintor, and J. S. Krahenbuhl. 1990. Microbiostatic effect of murine activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine. J. Immunol. 144:2725-2729.
2. Afonso, L. C. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235-237.
3. Aikawa, M. 1988. Human cerebral malaria. Am. J. Trop. Med. Hyg. 39:3-10.
4. Aitken, R., P. S. Coulson, and R. A. Wilson. 1988. Pulmonary leukocytic responses are linked to the acquired immunity of mice vaccinated with irradiated cercariae of Schislosoma munsoni. J. Immunol. 140:3573-3579.
5. Alleva, D. G., C. J. Burger, and K. D. Elgert. 1994. Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-α production. Role of tumor-derived IL-1, TGF-β, and prostaglandin E2. J. Immunol. 153: 1674-1686.
6. Barnes, P. J., and F. Y. Liew. 1995. Nitric oxide and asthmatic inflammation. Immunol. Today 16:128-130.
7. Barral-Netto, M., A. Barral, C. E. Brownell, Y. A. W. Skeiky, L. R. Ellingsworth, D. R. Twardzik, and S. G. Reed. 1992. Transforming growth factor-β in leishmanial infection: a parasite escape mechanism. Science 257: 545-548.
8. Bate, C. A., and D. Kwiatkowski. 1994. A monoclonal antibody that recognizes phosphatidylinositol inhibits induction of tumor necrosis factor alpha by different strains of Plasmodium falciparum. Infect. Immun. 62:5261-5266.
9. Beaman, M. H., C. S. Subauste, S.-Y. Wong, and J. S. Remington. 1994. Toxoplasma-macrophage interactions. Immunol. Ser. 60:475-493.
10. Beckman, J. S., T. W. Beckman, J. Chen, P. A. Marshall, and B. S. Freeman. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87:1620-1624.
11. Birkland, T. P., J. P. Sypek, and D. J. Wyler. 1992. Soluble TNF and membrane TNF expressed on CD4+ T lymphocytes differ in their ability to activate macrophage antileishmanial defense. J. Leukocyte Biol. 51:296-299.
12. Billiar, I. R., R. A. Hoffman, R. D. Curran, J. M. Langehr, and R. L. Simmons. 1992. A role for inducible nitric oxide biosynthesis in the liver in inflammation and in the allogenic immune response. J. Lab. Clin. Med. 120:192-197.
13. Bogdan, C., and C. Nathan. 1993. Modulation of macrophage function by transforming growth factor β interleukin-4 and interleukin-10. Ann. N. Y. Acad. Sci. 685:713-739.
14. Bohne, W., J. Heesemann, and U. Gross. 1994. Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: a possible role for nitric oxide in triggering stage conversion. Infect. Immun. 62:1761-1767.
15. Boros, D. L. 1989. Immunopathology of Schistosoma mansoni infection. Clin. Microbiol. Rev. 2:250-269.
16. Bredt, D. S., P. H. Hwang, C. Glatt, C. Lowenstein, R. R. Reed, and S. H. Snyder. 1991. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature (London) 351:714-718.
17. Bredt, D. S., and S. H. Snyder. 1990. Isolation of nitric oxide synthetase. a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. USA 87:682-685.
18. Bukrinsky, M. I., H. S. L. M. Nottet, H. Schmidtmayerova, L. Dubrovsky, C. R. Flanagan, M. E. Mullins, S. A. Lipton, and H. E. Gendelman. 1995. Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. J. Exp. Med. 181:735-745.
19. Candolfi, E., C. A. Hunter, and J. S. Remington. 1994. Mitogen- and antigen-specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates. Infect. Immun. 62:1995-2001.
20. Caulada-Benedetti, Z., F. Al-Zamel, A. Sher, and S. L. James. 1991. Comparison of Th1- and Th2-associated immune reactivities stimulated by single versus multiple vaccination of mice with irradiated Schistosoma mansoni cercariae. J. Immunol. 146:1655-1660.
21. Chandler, L. J., K. Kopnisky, E. Richards, F. T. Crews, and C. Sumners. 1995. Angiotensin II decreases inducible nitric oxide synthase expression in rat astroglial cultures. Am. J. Physiol. 268:C700-C707.
22. Chao, C. C., W. R. Anderson, S. Hu, G. Gekker, A. Martella, and P. K. Peterson. 1993. Activated microglia inhibit multiplication of Toxoplasma gondii via a nitric oxide mechanism. Clin. Immunol. Immunopathol. 67: 178-183.
23. Chao, C. C., S. Hu, G. Gekker, W. J. Novick, Jr., J. S. Remington, and P. K. Peterson. 1993. Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells. J. Immunol. 150:3404-3410.
24. Cho, H. F., Q. Xie, J. Calaycay, R. A. Muroford, K. M. Swiderek, T. D. Lee, and C. Nathan. 1992. Calmodulin is a subunit of nitric oxide synthase from macrophages. J. Exp. Med. 176:599-604.
25. Clark, I. A., N. H. Hunt, G. A. Butcher, and W. B. Cowden. 1987. Inhibition of murine malaria (Plasmodium chabaudi) in vivo by recombinant interferon-gamma or tumor necrosis factor. J. Immunol. 139:3493-3496.
26. Clark, I. A., K. A. Rockett, and W. B. Cowden. 1991. Proposed link between cytokines, nitric oxide and human cerebral malaria. Parasitol. Today 7:205-207.
27. Clark, I. A., K. A. Rockett, and W. B. Cowden. 1992. Possible central role of nitric oxide in conditions similar to cerebral malaria. Lancet 340:894-896.
28. Cook, H. T., A. Jansen, S. Lewis, P. Largen, M. Odonnell, D. Reavely, and V. Cattell. 1994. Arginine metabolism in experimental glomerulonephritis - interaction between nitric oxide synthase and arginase. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 267:F646-F653.
29. Cox, G. W., B. J. Mathieson, S. L. Giardina, and L. Varesio. 1990. Characterization of IL-2 receptor expression and function on murine macrophages. J. Immunol. 145:1719-1726.
30. Crawford, R. M., D. S. Finbloom, J. Ohara, W. E. Paul, and M. S. Meltzer. 1987. B cell stimulatory factor-1 (interleukin-4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J. Immunol. 139:135-141.
31. Crawford, R. M., D. A, Leiby, S. J. Green, C. A. Nacy, A. H. Fortier, and M. S. Meltzer. 1994. Macrophage activation: a riddle of immunological resistance. Immunol. Ser. 60:29-46.
32. Culotta, E., and D. E. Koshland, Jr. 1992. NO news is good news. Science 258:1862-1865.
33. Curran, R. D., T. R. Billiar, D. J. Stuher, K. Hofmann, and R. L. Simmons. 1989. Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J. Exp. Med. 170:1769-1774.
34. Dawson, T. M., V. L. Dawson, and S. H. Snyder. 1992. Novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann. Neurol. 32:297-311.
35. De Maria, R., M. G. Cifone, R. Trotta, M. R. Rippo, C. Festuccia, A. Santoni, and R. Testi. 1994. Triggering of human monocyte activation through CD69, a member of the natural killer cell gene complex family of signal transducing receptors. J. Exp. Med. 180:1999-2004.
36. Denis, M., and E. Ghadirian. 1992. Activated mouse macrophages kill Entamoeba histolytica trophozoites by releasing reactive nitrogen intermediates. Microb. Pathog. 12:193-198.
37. Didier, E. S., P. W. Varner, P. J. Didier, A. M. Aldras, et al. 1994. Experimental microsporidiosis in immunocompetent and immunodeficient mice and monkeys. Folia Parasitol. 41:1-11.
38. Ding, A., C. F. Nathan, J. Graycar, R. Derynack, D. J. Studehr, and S. Srimal. 1990. Macrophage deactivating factor and transforming growth factors-β1, -β2, and β3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ J. Immunol. 145:940-944.
39. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol. 141:2407-2414.
40. Doherty, T. M., R. Kastelein, S. Menon, S. Andrade, and R. L. Coffman, 1993. Modulation of murine macrophage function by IL-13. J. Immunol. 151:7151-7160.
41. Drapier, J. C., and J. B. Hibbs, Jr. 1986. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells: inhibition involves the iron-sulfur prosthetic group and is reversible. J. Clin. Invest. 78:790-797.
42. Drapier, J. C., and J. B. Hibbs, Jr. 1988. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells. J. Immunol. 140:2829-2838.
43. Drapier, J.-C., J. Wietzerbin, and J. B. Hibbs, Jr. 1988. Interferon-γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur. J. Immunol. 18:1587-1592.
44. Esparza, I., D. Mannel, A. Ruppel, W. Falk, and P. H. Krammer. 1987. Interferon γ and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of Schistosoma mansoni. J. Exp. Med. 166:589-594.
45. Fischerstenger, K., and F. Marciano-Cabral. 1992. The arginine-dependent cytolytic mechanism plays a role in destruction of Naegleria fowleri amoebae by activated macrophages. Infect. Immun. 60:5126-5131.
46. Fouad, S., I. P. Oswald, A. Sher, and S. L. James. 1994. Susceptibility of larval stages of Schistosoma mansoni to killing by activated macrophages correlates with parasite metabolic activity. Am. J. Trop. Med. Hyg. 51:230. (Abstract.)
47. Garthwaite, J. 1991. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci. 14:60-67.
48. Gazzinelli, R., Y. Xu, S. Hieny, A. Cheever, and A. Sher. 1992. Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J. Immunol. 149:175-180.
49. Gazzinelli, R. T., I. Eltoum, T. A. Wynn, and A. Sher. 1993. Acute cerebral toxoplasmosis is induced by in vivo neutralization and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J. Immunol. 151:3672-3681.
50. Gazzinelli, R. T., I. P. Oswald, S. Hieny, S. L. James, and A. Sher. 1992. The microbicidal activity of interferon-γ-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β. Eur. J. Immunol. 22:2501-2506.
51. Gazzinelli, R. T., I. P. Oswald, S. L. James, and A. Sher. 1992. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages. J. Immunol. 148:1792-1796.
52. Gibaldi, M. 1993. What is nitric oxide and why are so many people studying it? J. Clin. Pharmacol. 33:488-496.
53. Golden, J. M., and R. L. Tarleton. 1991. Trypanosoma cruzi: cytokine effects on macrophage trypanocidal activity. Exp. Parasitol. 72:391-402.
54. Granger, D. L., J. B. Hibbs, Jr., and L. M. Broadnax. 1991. Urinary nitrate excretion in relation to murine macrophage activation. J. Immunol. 146: 1294-1302.
55. Granger, D. L., and A. L. Lehninger. 1982. Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells. J. Cell Biol. 95:527-535.
56. Grau, G. E., H. Heremans, P.-F. Piguet, P. Pointaire, P.-H. Lambert, A. Billiau, and P. Vassalli. 1989. Monoclonal antibody against interferon-γ. can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc. Natl. Acad. Sci. USA 86:5572-5574.
57. Grau, G. E., T. E. Taylor, M. E. Molyneux, J. J. Wirima, P. Vassalli, M. Hommel, and P.-H. Lambert. 1989. Tumor necrosis factor and disease severity in children with falciparum malaria. N. Engl. J. Med. 320:1586-1591.
58. 15N]nitrate in biological fluids. Anal. Biochem. 126:131-138.
59. Green, S. J., R. M. Crawford, J. T. Hockmeyer, M. S. Meltzer, and C. A. Nacy. 1990. Leishmania major amastigotes initiate the L-arginine dependent killing mechanism in IFN-γ-stirnulated macrophages by induction of TNFα. J. Immunol. 145:4290-4297.
60. Green, S. J., M. S. Meltzer, J. B. Hibbs, Jr., and C. A. Nacy. 1990. Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism. J. Immunol. 144:278-283.
61. Green, S. J., C. A. Nacy, and M. S. Meltzer. 1991. Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens. J. Leukocyte Biol. 50:93-103.
62. Griscavage, J. M., N. E. Rogers, M. P. Sherman, and L. J. Ignarro. 1993. Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. J. Immunol. 151:6329-6337.
63. Gyan, B., M. Troye-Blomberg, P. Perlmann, and A. Bjorkman. 1994. Human monocytes cultured with and without interferon-gamma inhibit Plasmodium falciparum growth in vitro via secretion of reactive nitrogen intermediates. Parasite Immunol. 16:371-375.
64. Hamilton, T. A., and D. O. Adams. 1987. Molecular mechanisms of signal transduction in macrophages. Immunol. Today 8:151-158.
65. Heinzel, F. P., M. D. Sadick, B. J. Holaday. R. S. Dawkins, R. T. Pu, and R. M. Locksley. 1990. Cytokine production and function during murine leishmaniasis, p. 411-425. In A. Cerami and N. Agabian (ed.), Parasites: molecular biology, drug and vaccine design. Wiley-Liss, Inc., New York.
66. Hibbs, J. B., Jr., R. R. Taintor, and Z. Vavrin. 1984. Iron depletion: possible cause of tumor cell cytotoxicity induced by activated macrophages. Biochem. Biophys. Res. Commun. 123:716-723.
67. Hibbs, J. B., Jr., R. R. Taintor, Z. Vavrin, and E. M. Rachlin. 1988. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 157:87-94.
68. Hibbs, J. B., Jr., C. Westenfelder, R. R. Taintor, Z. Vavrin, C. Kablitz, R. L. Baranowski, J. H. Ward, R. L. Menlove, M. P. McMurry, J. P. Kushner, and W. Samlowski. 1992. Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. J. Clin. Invest. 89:867-877.
69. Hoff, R. 1975. Killing in vitro of Trypanosoma cruzi by macrophages from mice immunized with T. cruzi or BCG. and absence of cross-immunity on challenge in vivo. J. Exp. Med. 142:299-311.
70. Ignarro, L. J. 1989. Endothelium-derived nitric oxide: pharmacology and relationship to the actions of organic nitrate esters. Pharm. Res. 6:651-659.
71. Iyengar, R., D. J. Stuehr, and M. A. Marietta. 1987. Macrophage synthesis of nitrite, nitrate and N-nitrosamines: precursors and role of the respiratory burst. Proc. Natl. Acad. Sci. USA 84:6369-6373.
72. James, S. L., and D. Boros. 1994. Macrophages in schistosomiasis mansoni. Immunol. Ser. 60:461-173.
73. James, S. L., K. W. Cook, and J. K. Lazdins. 1990. Activation of human monocyte-derived macrophages to kill schistosomula of Schistosoma mansoni in vitro. J. Immunol. 145:2686-2690.
74. James, S. L., and J. Glaven. 1989. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J. Immunol. 143:4208-4212.
75. James, S. L., P. C. Natovitz, W. L. Farrar, and E. J. Leonard. 1984. Macrophages as effector cells of protective immunity in murine schistosomiasis: macrophage activation in mice vaccinated with radiation-attenuated cercariae. Infect. Immun. 44:569-575.
76. Janssens, S. P., A. Shimouchi, T. Quertermous, D. B. Bloch, and K. D. Bloch. 1992. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J. Biol. Chem. 267:14519-14522.
77. Jun, C. D., S. H. Kim, C. T. Soh, S. S. Kang, and H. T. Chung. 1993. Nitric oxide mediates the toxoplasmastatic activity of murine microglial cells in vitro. Immunol. Invest. 22:487-501.
78. Kaiser, L., R. C. Spickard, H. V. Sparks, and J. F. Williams. 1989. Dirofilaria immitis: alteration of in vivo canine femoral artery endothelium-dependent relaxation. Exp. Parasitol. 69:9-15.
79. Kaiser, L., P. D. Tithof, V. L. Lamb, and J. F. Williams. 1991. Depression of endothelium-dependent relaxation in aorta from rats with Brugia pahangi lymphatic filariasis. Circ. Res. 68:1703-1712.
80. Karunaweera, N., G. E. Grau, P. Gamage, R. Carter, and K. Mendis. 1992. Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxyxms in Plasmodium vivax malaria. Proc. Natl. Acad. Sci. USA 89:3200-3203.
81. Kasper, L. H., K. M. Currie, and M. S. Bradley. 1985. An unexpected response to vaccination with a purified major membrane tachyzoite antigen (P30) of Toxoplasma gondii. J. Immunol. 134:3426-3431.
82. Kassim, O., D. A. Dean, B. L. Mangold, and F. von Lichlenberg. 1992. Combined autoradiographic and histopathologic analysis of the fate of challenge Schistosoma mansoni schistosomula in mice immunized with irradiated cercariae. Am. J. Trop. Med. Hyg. 47:231-237.
83. Kilbourn, R. G., and P. Belloni. 1990. Endothelial cell production of nitrogen oxides in response to interferon-γ in combination with tumor necrosis factor, interleukin-1, or endotoxin. J. Natl. Cancer. Inst. 82:772-776.
84. Kilbourn, R. G., S. S. Gross, R. F. Lodato, J. Adams, et al. 1992. Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N-omega-amino-L-arginine. J. Natl. Cancer Inst. 84:1008-1016.
85. Klotz, F. W., L. F. Scheller, M. C. Seguin, N. Kumar, M. A. Marletta, S. J. Green, and A. F. Azad. 1995. Co-localization of inducible-nitric oxide synthase and Plasmodium berghei in hepatocytes from rats immunized with irradiated sporozoites. J. Immunol. 154:3391-3395.
86. Kolb, H., and V. Kolb-Bachofen. 1992. Nitric oxide: a pathogenetic factor in autoimmunity. Immunol. Today 13:157-160.
87. Kremsner, P. G., H. Grundmann, S. Neifer, K. Sliwa, G. Sahmuller, B. Hegenscheid, and U. Bienzle. 1991. Pentoxifylline prevents murine cerebral malaria. J. Infect. Dis. 164:605-608.
88. Kremsner, P. G., A. Nussler, S. Neifer, M. F. Chaves, U. Bienzle, G. Senaldi, and G. E. Grau. 1993. Malaria antigen and eytokine-induced production of reactive nitrogen intermediates by murine macrophages: no relevance to the development of experimental cerebral malaria. Immunology 78:286-290.
89. Kuhn, R. E. 1994. Macrophages in experimental Chagas' disease. Immunol. Ser. 60:495-502.
90. Kwiatkowski, D., A. V. S. Hill, I. Sambou, P. Twumasi, J. Castracane, K. R. Manogue, A. Cerami, D. R. Brewster, and B. M. Greenwood. 1992. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 336:1201-1204.
91. Kwon, N. S., D. J. Stuebr, and C. F. Nathan. 1991. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J. Exp. Med. 174:761-767.
92. Lamas, S., P. A. Marsden, G. K. Li, P. Tempst, and T. Michel. 1992. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc. Natl. Acad. Sci. USA 89:6348-6352.
93. Lamb, V. L., J. F. Williams, and L. Kaiser. 1993. Effect of serum from dogs infected with Dirofilaria immitis on endothelium-dependent relaxation of rat aorta in vitro. Am. J. Vet. Res. 54:2056-2059.
94. Lancaster, J. R., Jr., and J. B. Hibbs, Jr. 1990. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc. Natl. Acad. Sci. USA 87:1223-1227.
95. Langermans, J. A. M., M. E. B. Van Der Hulst, P. H. Nibbering, P. S. Hiemstra, L. Fransen, and R. Van Furth. 1992. IFN-γ-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor. J. Immunol. 148:568-574.
96. Lee, S. C., D. W. Dickson, C. F. Brosnan, and A. Casadevall. 1994. Human astrocytes inhibit Cryptococcus neoformans growth by a nitric oxide-mediated mechanism. J. Exp. Med. 180:365-369.
97. Leitch, G. J., and Q. He. 1994. Arginine-derived nitric oxide reduces fecal oocyst shedding in nude mice infected with Cryptosporidium parvum. Infect. Immun. 62:5173-5176.
98. Lepoivre, M., H. Boudid, and J. F. Petit. 1989. Antiproliferative activity of interferon-γ combined with lipopolysaccharide on murine adenocarcinoma: dependence on an L-arginine metabolism with production of nitrite and citrulline. Cancer Res. 49:1970-1976.
99. Li, Y., A. Severn, M. V. Rogers, and R. M. Palmer. 1992. Catalase inhibits nitric oxide synthesis and the killing of intracellular Leishmania tropica in murine macrophages. Eur. J. Immunol. 22:441-446.
100. Liew, F. Y., Y. Li, A. Severn, S. Millott, J. Schmidt, M. Salter, and S. Moncada. 1991. A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase in macrophages. Eur. J. Immunol. 21:2489-2494.
101. Liew, F. Y., S. Millott, Y. Li, R. Lelchuk, W. L. Chan, and H. Ziltener. 1989. Macrophage activation by interferon-γ from host-protective T cells is inhibited by interleukin IL-3 and IL-4 produced by disease promoting T cells in leishmaniasis. Eur. J. Immunol. 19:1227-1232.
102. Liew, F. Y., S. Millott, C. Parkinson, R. M. J. Palmer, and S. Moncada. 1990. Macrophage killing of Leishmania parasites in vivo is mediated by nitric oxide from L-arginine. J. Immunol. 144:4794-4797.
103. Liew, F. Y., L. Yun, and S. Milott. 1990. TNFα synergizes with IFNγ in mediating killing of Leishmania major through the induction of nitric oxide. J. Immunol. 145:4306-4310.
104. Lin, J. Y., and K. Chadee. 1992. Macrophage cytotoxicity against Entamoeba histolytica trophozoites is mediated by nitric oxide from L-arginine. J. Immunol. 148:3999-4005.
105. Lorsbach, R. B., and S. W. Russell. 1992. A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages. Infect. Immun. 60:2133-2135.
106. Lowenstein, C. J., C. S. Glatt, D. S. Bredt, and S. H. Snyder. 1992. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc. Natl. Acad. Sci. USA 89:6711-6715.
107. Lowenstein, C. J., and S. H. Snyder. 1992. Nitric oxide, a novel biologic messenger. Cell 70:705-707.
108. Lyons, C. R., G. Orloff, and J. M. Cunningham. 1992. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J. Biol. Chem. 267:6370-6374.
109. Marietta, M. A. 1989. Nitric oxide: biosynthesis and biological significance. Trends Biochem. Sci. 14:488-492.
110. Marletta, M. A. 1994. Nitric oxide synthase: aspects concerning structure and catalysis. Cell 78:927-930.
111. Martin, E., C. Nathan, and Q. Xie. 1994. Role of Interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 180:977-984.
112. Mauel, J., A. Ransijn, and Y. Buchmuller-Rouiller. 1991. Killing of Leishmania parasites in activated murine macrophages is based on an L-arginine-dependent process that produces nitrogen derivatives. J. Leukocyte Biol. 49:73-82.
113. McGuire, W., A. V. S. Hill, C. E. M. Allsopp. B. M. Greenwood, and D. Kwiatkowski. 1994. Variation in lhe TNFα promoter region associated with susceptibility to cerebral malaria. Nature (London) 371:508-511.
114. McLaren, D. J., and S. L. James. 1985. Ultrastructural studies of the killing of schistosomula of Schistosoma mansoni by activated macrophages in vitro. Parasite Immunol. 7:315-331.
115. Mellouk, S., S. J. Green, C. A. Nacy, and S. U Hoffman. 1991. IFN-γ inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism. J. Immunol. 146: 3971-3976.
116. Mellouk, S., S. L. Hoffman, Z. Z. Liu, P. De la Vega, T. R. Billiar, and A. K. Nussler. 1994. Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by gamma interferon and the patasite itself: enhancement by exogenous tetrahydrobiopterin. Infect. Immun. 62:4043-4046.
117. Menson, E. N., and R. A. Wilson. 1990. Lung-phase immunity to Schistosoma mansoni: definition of alveolar macrophage phenotypes after vaccination and challenge of mice. Parasite Immunol. 12:353-366.
118. Meshnick, S. R., and J. W. Eaton. 1981. Leishmanial superoxide dismutase: a possible target for chemotherapy. Biochem. Biophys. Res. Commun. 102:970-976.
119. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
120. Motard, A., I. Landau, A. Nussler, G. Grau, D. Baccam, D. Mazier, and G. A. T. Targett. 1993. The role of reactive nitrogen intermediates in modulation of gametocyte infectivity of rodent malaria parasites. Parasite Immunol. 15:21-26.
121. Munoz-Fernandez, M. A., M. A. Fernandez, and M. Fresno. 1992. Synergism between tumor necrosis factor-α and interferon-γ on macrophage activation for the killing of Tiypanosoma cruzi through a nitric oxide-dependent mechanism. Eur. J. Immunol. 22:301-307.
122. Munoz-Fernandez, M. A., M. A. Fernandez, and M. Fresno. 1992. Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-alpha and IFN-gamma through a nitric oxide-dependent mechanism. Immunol. Lett. 33:35-40.
123. Murray, H. W. 1994. Interferon-gamma and host antimicrobial defense: current and future applications. Am. J. Med. 97:459-467.
124. Murray, H. W., A. M. Granger, and R. F. Teitlebaum. 1991. γ-Interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: antimicrobial role of limiting intracellular iron. Infect. Immun. 59:4684-4686.
125. Murray, H. W., and R. F. Teitlebaum. 1992. L-Arginine-dependent reactive nitrogen intermediates and the antimicrobial effect of activated human mononuclear phagocytes. J. Infect. Dis. 165:513-517.
126. Nathan, C. 1991. A commentary: inducible nitric oxide synthase. Res. Immunol. 142:600-602.
127. Nathan, C., and Q. Xie. 1994. Nitric oxide synthases: roles, tolls, and controls. Cell 78:915-918.
128. Nelson, B. J., P. Ralph, S. J. Green, and C. A. Nacy. 1991. Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-β1. J. Immunol. 146: 1849-1857.
129. Nussler, A., J. C. Drapier, L. Renia, S. Pied, F. Miltgen, M. Gentilini, and D. Mazier. 1991. L-Arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin-6 stimulation. Eur. J. Immunol. 21:227-230.
130. Nussler, A. K., and T. R. Billiar. 1993. Inflammation, immunoregulation, and inducible nitric oxide synthase. J. Leukocyte Biol. 54:171-178.
131. Nussler, A. K., M. Di Silvio, T. R. Billiar, R. A. Hoffman, D. A. Geller, R. Selby, J. Madariaga, and R. L. Simmons. 1992. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J. Exp. Med. 176:261-264.
132. Nussler, A. K., L. Renia, V. Pasquetto, F. Miltgen, H. Matila, and D. Mazier. 1993. In vivo induction of the nitric oxide pathway in hepatocytes after injection with irradiated malaria sporoxoites, malaria blood parasites or adjuvants. Eur. J. Immunol. 23:882-887.
133. Ohshima, H., and H. Bartsch. 1994. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res. 305:253-264.
134. Oswald, I. P., I. Eltoum, T. A. Wynn, B. Schwartz, P. Caspar, D. Paulin, A. Sher, and S. L. James. 1994. Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni. through production of nitric oxide. Proc. Natl. Acad. Sci. USA 91:999-1003.
135. Oswald, I. P., S. Fouad, and S. L. James. Unpublished data.
136. Oswald, I. P., R. I. Gazzinelli, A. Sher, and S. L. James. 1992. 1L-10 synergizes with IL-4 and transforming growth factor β to inhibit macrophage cytotoxic activity. J. Immunol. 148:3578-3582.
137. Oswald, I. P., T. A. Wynn, A. Sher, and S. L. James. 1992. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor α required as a costimulatory factor for interferon γ-induced activation. Proc. Natl. Acad. Sci. USA 89:8676-8680.
138. Pace, J. L., S. W. Russell, M. A. Torres, H. M. Johnson, and P. W. Gray. 1983. Recombinant mouse interferon-γ induces the priming step in macrophage activation for tumor cell killing. J. Immunol. 130:2011-2015.
139. Palmer, R. M. J., A. G. Ferrige, and S. Moncada. 1987. Nitric oxide release accounts for the biological activity of endothelium derived-relaxing factor. Nature (London) 327:524-526.
140. Pearce, E. J., and S. L. James. 1986. Post lung-stage schistosomula of Schistosoma mansoni exhibit transient susceptibility to macrophage-mediated cytotoxicity in vitro that may relate to late phase killing in vivo. Parasite Immunol. 8:513-527.
141. Pemberton, R. M., L. K. Smythies, A. P. Mountford, and R. A. Wilson. 1991. Patterns of cytokine production and proliferation by T lymphocytes differ in mice vaccinated or infected with Schistosoma mansoni. Immunology. 73: 327-333.
142. Phipps, R. P., S. H. Stein, and R. L. Roper. 1991. A new view of prostaglandin E regulation of the immune response. Immunol. Today 12:349-351.
143. Pichyangkul, S., P. Saengkrai, and H. K. Webster. 1994. Plasmodium falciparum pigment induces monocytes to release high levels of tumor necrosis factor-alpha and interleukin-1 beta. Am. J. Trop. Med. Hyg. 51:430-435
144. Pober, J. S., M. A. Gimbrone, L. A. Lapierre, D. L. Mendrick, W. Fiers, R. Rothlein, and T. A. Springer. 1986. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor and immune Interferon. J. Immunol. 137:1893-1896.
145. Pou, S., W. Pou, D. S. Bredt, S. H. Snyder, and G. M. Rosen. 1992. Generation of superoxide by purified brain nitric oxide synthase. J. Biol. Chem. 267:24173-24176.
146. Raddassi, K., J. F. Petit, and G. Lemaire. 1993. LPS-induced activation of primed murine peritoneal macrophages is modulated by prostaglandins and cyclic nucleotides. Cell. Immunol. 149:50-64.
147. Rajan, T. V. (University of Connecticut). 1995. Personal communication.
148. Reed, S. G. 1988. In vivo administration of recombinant IFN-gamma induces macrophage activation and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infection. J. Immunol. 140:4342-4347.
149. Reed, S. G., C. F. Nathan, D. L. Pihl, P. Rodricks, K. Shanebeck, P. J. Conlon, and K. H. Grabstein. 1987. Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with Interferon γ. J. Exp. Med. 166:1734-1746.
150. Ribeiro, J. M. C., J. M. H. Hazzard, R. H. Nussenzveig, D. E. Champagne, and F. A. Walker. 1993. Reversible binding of nitric oxide by a salivary heme protein from a bloodsucking insect. Science 260:539-541.
151. Roach, T. I., D. Chatterjee, and J. M. Blackwell. 1994. Induction of earlyresponse genes KC and JE by mycobacterial lipoarabinomannans: regulalion of KC expression in murine macrophages by Lsh/Ity/Bcg (Candidat Nramp). Infect. Immun. 62:1176-1184.
152. Roberts, W. K., and A. Vasil. 1982. Evidence for the identity of murine gamma interferon and macrophage activating factor. J. Interferon Res. 2:519-532.
153. Rockett, K. A., M. M. Awburn, B. B. Aggarwal, W. B. Cowden, and I. A. Clark. 1992. In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interieukin-1. Infect. Immun. 60:3725-3730.
154. Rockett, K. A., M. M. Awburn, W. B. Cowden, and I. A. Clark. 1991. Killing of Plasmodium falciparum in vitro by nitric oxide derivatives. Infect. Immun. 59:3280-3283.
155. Rockett, K. A., M. M. Awburn, E. J. Rockett, and I. A. Clark. 1994. Tumor necrosis factor and interleukin-1 synergy in the context of malaria pathology. Am. J. Trop. Med. Hyg. 50:735-742.
156. Rockett, K. A., M. M. Awburn, E. J. Rockett, W. B. Cowden, and I. A. Clark. 1994. Possible role of nitric oxide in malarial immunosuppression. Parasite Immunol. 16:243-249.
157. Roland, C. R., L. Walp, R. M. Stack, and M. W. Flye. 1994. Outcome of Kupffer cell antigen presentation to a cloned murine Th1 lymphocyte depends on the inducibility of nitric oxide synthase by IFNγ. J. Immunol. 153:5453-5464.
158. Schleifer, K. W., and J. M. Mansfield. 1993. Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J. Immunol. 151:5492-5503.
159. Schmidt, H. H. H. W., and U. Walter. 1994. NO at work. Cell 78:919-925.
160. Schneeman, M., G. Schoedon, S. Hofer, N. Blau, L. Guerrero, and A. Schaffner. 1993. Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J. Infect. Dis. 167:1358-1363.
161. Scott, P., S. L. James, and A. Sher. 1985. The respiratory burst is not required for killing of intracellular and extracellular parasites by a lymphokine-activated macrophage cell line. Eur. J. Immunol. 15:553-558.
162. Seguin, M. C., F. W. Klotz, I. Schneider, J. P. Weir, M. Goodbary, M. Slayter, J. J. Raney, J. U. Aniagolu, and S. J. Green. 1994. Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interteron γ and CD8+ T cells. J. Exp. Med. 180:353-358.
163. Sher, A., and R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385-409.
164. Sher, A., R. L. Coffman, S. Hieny, and A. W. Cheever. 1990. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J. Immunol. 145:3911-3916.
165. Sher, A., S. L. James, A. J. G. Simpson, J. K. Lazdins, and M. S. Meltzer. 82. Macrophages as effector cells of protective immunity in murine schistosomiasis. III. Loss of susceptibility to macrophage-mediated killing during maturation of S. mansoni schistosomula from the skin to the lung-stage. J. Immunol. 128:1876-1879.
166. Sher, A., I. P. Oswald, S. Hieny, and R. T. Cazzinelli. 1993. Tomplasma gondii induces a T-independent IFN-γ response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-α. J. Immunol. 150:3982-3989.
167. Sibley, L. D. 1993. Interactions between Toxoplasma gondii and its mammalian host cells. Semin. Cell Biol. 4:335-344.
168. Sibley, L. D., L. B. Adams, Y. Fukutomi, and J. L. Krabenbuhl. 1991. Tumor necrosis factor-α triggers antitoxoplasmal activity of IFN-γ primed macrophages. J. Immunol. 147:2340-2345.
169. Sicher, S. C., M. A. Vazquez, and C. Y. Lu. 1994. Inhibition of macrophage Ia expression by nitric oxide. J. Immunol. 153:1293-1300.
170. Silva, J. S., P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed. 1992. Interleukin 10 and Interferon γ regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 175:169-174.
171. Silva, J. S., D. R. Twardzik, and S. G. Reed. 1991. Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor-β (TGF-β). J. Exp. Med. 174:539-545.
172. Skamene, E., S. L. James, M. S. Meltzer, and M. S. Nesbitt. 1984. Genetic control of macrophage activation for killing of extracellular targets. J. Leukocyte Biol. 35:65-69.
173. Smythies, L. E., P. S. Coulson, and R. A. Wilson. 1992. Monoclonal antibody to IFN-γ modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae. J. Immunol. 149:3654-3658.
174. Smythies, L. E., R. M. Pemberton, P. S. Coulson, A. P. Mountford, and R. A. Wilson. 1992. T cell-derived cytokines associated with pulmonary immune mechanisms in mice vaccinated with irradiated cercariae of Schistosoma mansoni. J. Immunol. 148:1512-1518.
175. Stamler, J. S. 1994. Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell 78:931-936.
176. Stamler, J. S., D. I. Simon, J. A. Osborne, M. E. Mullins, O. Jaraki, T. Michel, D. J. Singel, and J. Loscalzo. 1992. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc. Natl. Acad. Sci. USA 89:444-448.
177. Stamler, J. S., D. J. Singel, and J. Loscalzo. 1992. Biochemistry of nitric oxide and its redox-activated forms. Science 258:1898-1902.
178. Stenger, S., W. Solbach, M. Rollinghoff, and C. Bogdan. 1991. Cytokine interactions in experimental cutaneous leishmaniasis. II. Endogenous tumor necrosis factor-α production by macrophages is induced by the synergistic action of interferon (IFN)-γ and interleukin (IL)-4 and accounts for the antiparasitic effect mediated by IFN-γ and IL-4. Eur. J. Immunol. 21:1669-1675.
179. Stenger, S., H. Thuring, M. Rollinghoff, and C. Bogdan. 1994. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J. Exp. Med. 180:783-793.
180. Sternberg, J., and F. McGuigan. 1992. Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection. Eur. J. Immunol. 22:2741-2744.
181. Stuehr, D. J., O. A. Fasehun, N. S. Kwon, S. S. Gross, J. A. Gonzalez, R. Levi, and C. F. Nathan. 1991. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J. 5:98-103.
182. Stuehr, D. J., and M. A. Marletta. 1985. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA 82:7738-7742.
183. Suzuki, Y., F. K. Conley, and J. S. Remington. 1989. Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice. J. Immunol. 13:2045-2050.
184. Svedersky, L. P., C. V. Benton, W. H. Berger, E. Rinderknecht, R. N. Harkins, and M. S. Palladino. 1984. Biological and antigenic similarities of murine interferon-γ and macrophage activating factor. J. Exp. Med. 159: 812-820.
185. Taylor-Robinson, A. W., F. Y. Liew, A. Severn, D. Xu, S. J. McSorley, P. Garside, J. Padron, and K. S. Phillips. 1994. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur. J. Immunol. 14:980-984.
186. Tielens, A. G. M. 1994. Energy generation in parasitic helminths. Parasitol. Today 10:346-352.
187. Torrico, F., H. Heremans, M. T. Rivera, E. V. Marck, A. Billiau, and Y. Carlier. 1991. Endogenous IFN-γ is required for resistance to acute Trypanosoma cruzi infection in mice. J. Immunol. 146:3626-3632.
188. Tsuji, M., Y. Miyahira, R. S. Nussenzweig, M. Aguet, M. Reichel, and F. Zavala. 1995. Development of antimalaria immunity in mice lacking IFN-γ receptor. J. Immunol. 154:5338-5344.
189. Vespa, G. N., F. Q. Cunha, and J. S. Silva. 1994. Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro. Infect. Immun. 62:5177-5182.
190. Vieth, M., A. Will, K. Schroppel, M. Rollinghoff, and A. Gessner. 1994. Interleukin-10 inhibits antimicrobial activity against Leishmania major in murine macrophages. Scand. J. Immunol. 40:403-109.
191. + T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections. Immunology 67:466-472.
192. Vincendeau, P., and S. Daulouede. 1991. Macrophage cytostatic effect on Trypanosoma musculi involves an L-arginine-dependent mechanism. J. Immunol. 146:4338-4343.
193. Vincendeau, P., S. Daulouede, B. Veyret, M. L. Darde, B. Bouteille, and J. L. Lemesre. 1992. Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei. Exp. Parasitol. 75: 353-360.
194. Vollmer, T. L., M. K. Waldor, L. Steinman, and F. K. Conley. 1987. Depletion of T-4+ lymphocytes with monoclonal antibody reactivates toxoplasmosis in the central nervous system: a model of superinfection in AIDS. J. Immunol. 138:3737-3741.
195. Wei, X., I. G. Charles, A. Smith, J. Ure, G. Feng, F. Huang, D. Xu, W. Muller, S. Moncada, and F. Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (London) 375:408-411.
196. Weinberg, E. D. 1992. Iron depletion: a defense against intracellular infection and neoplasia. Life Sci. 50:1289-1297.
197. Werner-Felmayer, G., E. R. Werner, D. Fuchs, A. Hausen, G. Reibnegger, and H. Wachter. 1990. Tetrahydrobiopterin dependent formation of nitrite and nitrate in murine fibroblasts. J. Exp. Med. 172:1599-1507.
198. Wirth, J. J., F. Kierszenbaum, G. Sonnenfeld, and A. Zlotnik. 1985. Enhancing effects of gamma interferon on phagocytic cell association with and killing of Trypanosoma cruzi. Infect. Immun. 49:61-66.
199. Wilson, R. A., and P. S. Coulson. 1989. Lung-phase immunity to schistosomes: a new perspective on an old problem. Parasitol. Today 5:274-278.
200. Woods, M. S., J. Mayer, T. G. Evans, and J. B. Hibbs, Jr. 1994. Antiparasitic effects of nitric oxide in an in vitro model of Chlamydia trachomatis infection and an in vivo murine model of Leishmania major infection. Immunol. Ser. 60:179-195.
201. Wynn, T. A., I. P. Oswald, I. A. Eltoum, P. Caspar, C. J. Lowenstein, F. A. Lewis, S. L. James, and A. Sher. 1994. Elevated expression of Th1 cytokines and NO synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni. J. Immunol. 153:5200-5209.
202. Xie, Q.-W., H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, and C. Nathan. 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256: 225-228.
203. Zembala, M., M. Siedlar, J. Marcinkiewicz, and J. Pryjma. 1994. Human monocytes are stimulated for nitric oxide release in vitro by some tumor cells but not by cytokines and lipopolysaccharide. Eur. J. Immunol. 24:435-439.
204. Zwilling, B. S., and M. E. Hilburger. 1994. Macrophage resistance genes: Bcg/Ity/Lsh. Immunol. Ser. 60:233-245.