The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-α

AIDS

Volumn 9, Issue 2, 1995, Pages 137-143

  Yeung, Michael C ^a   Pulliam, Lynn ^b   Lau, Allan S ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

AIDS; Apoptosis; Cytokines; Dementia; HIV 1 gp120; Neuropathology

Indexed keywords

ENVELOPE PROTEIN; GLYCOPROTEIN GP 120; INTERLEUKIN 6; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

AIDS RELATED COMPLEX; ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CELL; CELL AGGREGATION; CELL NUCLEUS MEMBRANE; CHROMATIN; CONTROLLED STUDY; DEMENTIA; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; MACROPHAGE; MICROGLIA; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0028853061     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199502000-00004     Document Type: Article

References (56)

1. Spencer DC, Price RW: Human immunodeficiency virus and the central nervous system. Ann Rev Microbiol 1992, 46:655-693.
2. Price RW, Brew BJ, Rosenblum M: The AIDS dementia complex and HIV-1 brain infection: a pathogenetic model of virus-immune interaction. Res Publ Assoc Res Nerv Ment Dis 1990, 68:269-290.
3. Navia BA, Cho ES, Petito CK, Price RW: The AIDS dementia complex: II. Neuropathology. Ann Neurol 1986, 19:525-535
4. Pulliam L, Herndier BC, Tang NM, McGrath MS: Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest 1991, 87:503-512.
5. Guilian D, Vaca K, Noonan CA: Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 1990, 250:1593-1596.
6. Brenneman DE, Westbrook GL, Fitzgerald SP, et al.: Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature 1988, 335:639-642.
7. Dreyer EB, Kaiser PK, Offemann JT, Lipton SA: HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science 1990, 248:364-367.
8. Pulliam L, West D, Haigwood N, Swanson RA: HIV-1 envelope gp120 alters astrocytes in human brain cultures. AIDS Res Hum Retroviruses 1993, 9:439-444.
9. Lipton SA, Sucher NJ, Kaiser PK, Dreyer EB: Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 1991, 7:111-118.
10. Levy JA: Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 1993, 57:183-289.
11. Epstein LC, Gendelman HE: Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann Neurol 1993, 33:429-436.
12. Gallo P, Frei K, Rordorf C, Lazdins J, Tavolato B, Fontana A: Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J Neuroimmunol 1989, 23:109-116.
13. Matsuyama T, Kobayashi N, Yamamoto N: Cytokines and HIV infection: is AIDS a tumor necrosis factor disease? AIDS 1991, 5:1405-1417.
14. Merrill JE, Koyanagi Y, Chen IS: Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type T binding to the CD4 receptor. J Virol 1989, 63:4404-4408.
15. Merrill JE, Koyanagi Y, Zack J, Thomas L, Martin F, Chen IS: Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J Virol 1992, 66:2217-2225.
16. Merrill JE, Chen IS: HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease. FASEB J 1991, 5:2391-2397.
17. Achim CL, Heyes MP, Wiley CA: Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains. J Clin Invest 1993, 91:2769-2775.
18. Tyor WR, Glass JD, Griffin JW, et al.: Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann Neurol 1992, 31:349-360.
19. Wesselingh SL, Power C, Glass JD, et al.: Intracerebral Cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann Neurol 1993, 33:576-582.
20. Pulliam L, Berens ME, Rosenblum ML: A normal human brain cell aggregate model for neurobiological studies. J Neurosci Res 1988, 21:521-530.
21. Hertz L, Jurlink BHJ, Szuchet S: Cell cultures. In Handbook of Neurochemistry. Edited by Lajtha A. New York: Plenum Press; 1985:603-661.
22. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162:156-159.
23. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 1975, 98:503-517.
24. Church CM, Gilbert W: Genomic sequencing. Proc Natl Acad Sci USA 1984, 81:1991-1995.
25. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 1989:10.14-10.15.
26. Wiley CA, Achim CL, Schrier RD, Heyes MP, McCutchan JA, Grant I: Relationship of cerebrospinal fluid immune activation associated factors to HIV encephalitis. AIDS 1992, 6:1299-1307.
27. Yoshioka M, Shapshak P, Srivastava AK, et al.: Expression of HIV-1 and interleukin-6 in lumbosacral dorsal root ganglia of patients with AIDS. Neurology 1994, 44:1120-1130.
28. Perrella O, Carrieri PB, Guarnaccia D, Soscia M: Cerebrospinal fluid cytokines in AIDS dementia complex. J Neurol 1992, 239:387-388.
29. Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW: Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol 1993, 150:2659-2667.
30. Grimaldi LM, Martino GV, Franciotta DM, et al.: Elevated alpha-tumor necrosis factor levels in spinal fluid from HIV-1-infected patients with central nervous system involvement. Ann Neurol 1991, 29:21-25.
31. Van Damme J, Opdenakker G, Simpson RJ, et al.: Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med 1987, 165:914-919.
32. Hirano T: The biology of interleukin-6. In Interleukins: Molecular Biology and Immunology. Edited by Kishimoto T. Basel: Karger; 1992:153-180.
33. Norris JG, Benveniste EN: Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine. J Neuroimmunol 1993, 45:137-145.
34. Clouse KA, Cosentino LM, Weih KA, et al.: The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion. J Immunol 1991, 147:2892-2901.
35. Oyaizu N, Chirmule N, Ohnishi Y, Kalyanaraman VS, Pahwa S: Human immunodeficiency virus type 1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4+ T-cell clones. J Virol 1991, 65:6277-6282.
36. Graeber MB, Streit WJ, Kreutzberg GW: The third glial cell type, the microglia: cellular markers of activation in situ. Acta Histochem Suppl 1990, 38:157-160.
37. Cohen JJ: Apoptosis. Immunol Today 1993, 14:126-130.
38. Allen PD, Bustin SA, Macey MG, Johnston DH, Williams NS, Newland AC: Programmed cell death (apoptosis) in immunity and haematological neoplasia. Br J Biomed Sci 1993, 50:135-149.
39. Mangan DF, Mergenhagen SE, Wahl SM: Apoptosis in human monocytes: possible role in chronic inflammatory diseases. J Periodontol 1993, 64:461-466.
40. Korsching S: The neurotrophic factor concept: a reexamination. J Neurosci 1993, 13:2739-2748.
41. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RP, Miedema F: Programmed death of T cells in HIV-1 infection. Science 1992, 257:217-229.
42. Rey-Cuille MA, Galabru J, Laurent-Crawford A, Krust B, Montagnier L, Hovanessian AG: HIV-2 EHO isolate has a divergent envelope gene and induces single cell killing by apoptosis. Virology 1994, 202:471-476.
43. Hinshaw VS, Olsen CW, Dybdahl-Sissoko N, Evans D: Apoptosis: a mechanism of cell killing by influenza A and B viruses. J Virol 1994, 68:3667-3673.
44. Cairns JA, Guy GR, Tan YH: Interleukin-6 regulates the cytotoxic effect of tumour necrosis factor on U937 cells. Immunology 1992, 75:669-673.
45. Benveniste EN, Sparacio SM, Norris JG, Grenett HE, Fuller GM: Induction and regulation of interleukin-6 gene expression in rat astrocytes. J Neuroimmunol 1990, 30:201-212.
46. Robbins DS, Shirazi Y, Drysdale BE, Lieberman A, Shin HS, Shin ML: Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes. J Immunol 1987, 139:2593-2597.
47. Selmaj KW, Raine CS: Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 1988, 23:339-346.
48. Cohen-Kaminsky S, Devergne O, Delattre RM, et al.: Interleukin-6 overproduction by cultured thymic epithelial cells from patients with myasthenia gravis is potentially involved in thymic hyperplasia. Eur Cytokine Netw 1993, 4:121-132.
49. Selmaj K, Shafit-Zagardo B, Aquino DA, et al.: Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. J Neurochem 1991, 57:823-830.
50. Rutka JT, Smith SL: Transfection of human astrocytoma cells with glial fibrillary acidic protein complementary DNA: analysis of expression, proliferation, and tumorigenicity. Cancer Res 1993, 53:3624-3631.
51. Swingler S, Easton A, Morris A: Cytokine augmentation of HIV-1 LTR-driven gene expression in neural cells. AIDS Res Hum Retroviruses 1992, 8:487-493.
52. Glass JD, Wesselingh SL, Selnes OA, McArthur JC: Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 1993, 43:2230-2237.
53. Campbell IL, Abraham CR, Masliah E, et al.: Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci USA 1993, 90:10061-10065.
54. Toggas SM, Masliah E, Rockenstein EM, Rail GF, Abraham CR, Mucke L: Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 1994, 367:188-193.
55. Wahl SM, Allen JB, McCartney-Francis N, et al.: Macrophage-and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome. J Exp Med 1991, 173:981-991.
56. Gelbard HA, Nottet HS, Swindells S, et al.: Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J Virol 1994, 68:4628-4635.