In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1

Virology

Volumn 206, Issue 1, 1995, Pages 381-386

  Yu, Mang ^a   Poeschla, Eric ^a   Yamada, Osamu ^a   Degrandis, Paula ^b   Leavitt, Mark C ^a   Heusch, Marina ^a   Yees, Jiing Kuala ^c   Wong Stahl, Flossie ^a   Hampel, Arnold ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHERN ILLINOIS UNIVERSITY   (United States)

^c Department of Pediatrics ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; RIBOZYME;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE THERAPY; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL;

BASE SEQUENCE; CELL LINE; GENE PRODUCTS, POL; HIV-1; HUMAN; HYDROLYSIS; KINETICS; MOLECULAR SEQUENCE DATA; RNA, CATALYTIC; RNA, VIRAL; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALIA; FELIS CATUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0028852546     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/S0042-6822(95)80053-0     Document Type: Article

References (24)

1. Altman, S. (1993). RNA enzyme-directed gene therapy. Proc. Natl. Acad. Sei. USA 90, 10898-10900.
2. Altschuler, M., Tritz, R., and Hampel, A. (1992). A method for generating transcripts with defined 5' and 3' termini by autolytic processing. Gene 122, 85.
3. Anderson, P. J., Monforte, R., Tritz, S., Nesbitt, J., Hearst, H., and Hampel, A. (1994). Mutagenesis of the hairpin ribozyme. Nucleic Acids Res., in press.
4. Aspinall, J., The computer program BIOSEQ, available upon request, Biology Department, Northern Illinois University, DeKalb, IL 60115.
5. Cech, T., Zaug, A., and Grabowski, P. (1981). In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guano- sine nucleotide in the excision of the intervening sequence. Cell 27, 487-496.
6. Cheong, C., Varani, G., and Tinoco, I. (1990). Solution structure of an unusually stable RNA hairpin, 5' GGAC(UUCG)GUCC. Nature 346, 680-682.
7. Chomczynski, P., and Sacchi, N. (1987). Single step method of RNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
8. Forster, T., and Symons, R. (1987). Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site. Cell 50, 9-16.
9. Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., and Altman, S. (1983). The RNA motif of ribonuclease P is the catalytic subunit of the enzyme., Cell 35, 849-857.
10. Hampel, A., and Tritz, R. (1989). RNA catalytic properties of the minimum (-)sTRSV sequence. Biochemistry 28, 4929-4933.
11. Hampel, A., Tritz, R., Hicks, M., and Cruz, P. (1990). Hairpin catalytic RNA modeh evidence for helices and sequence requirement for substrate RNA. Nucleic Acids Res. 18, 299-304.
12. Hampel, A, Nesbitt, S., Tritz, R., and Altschuler, M. (1993). The hairpin ribozyme. In "Methods: A Companion to Methods in Enzymology” (J. Abelson and M. Simon, Eds.), Vol. 5, pp. 37-42. American Press, San Diego.
13. Leavitt, M. C., Yu, M., Yamada, O., Kraus, G., Looney, D., Poeschla, E., and Wong-Staal, F. (1994). Transfer of an Anti-HIV-1 ribozyme gene into primary human lymphocytes. Gene Therapy, submitted for publication.
14. Meyer, G. (1992). “Human Retroviruses and AIDS: A Compilation and Analysis of Nucleic Acid Sequences." Los Alamos.
15. Ojwang, J., Hampel, A., Looney, D., Wong-Staal, F., and Rappaport, J. (1992). Inhibition of human immunodeficiency virus type-1 (HIV-I) expression by a hairpin ribozyme. Proc. Natl. Acad. Scl. USA 89, 10802-10806.
16. Pelletier, J., and Sonenberg, N. (1988). Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334, 320-325.
17. Ratner, L., Fisher, A., Jagodzinski, L., Mitsuya, H., Liou, R., Gallo, R., and Wong-Staal, F. (1987). Complete nucleotide sequences of functional clones of the AIDS virus. AIDS Res. Plum. Retroviruses 3, 57-69.
18. Rossi, J., Elkins, D., Zaia, J., and Sullivan, S. (1992). Ribozymes as anti-HIV-1 therapeutic agents: principles, applications, and problems. AIDS Res. Hum. Retroviruses. 8, 183-189.
19. Sarver, N., Johnston, M., Hampel, A., Zaia, J., Cantin, E., Chang, P., and Rossi, J. (1990). Exploring catalytic RNAs (ribozymes) as antiHIV agents. In “Gene Regulation and AIDS” (T. Papas, Ed.), pp. 305-325. Golf Publisher, Houston.
20. Uhlenbeck, O. (1987). A small catalytic oligoribonucleotide. Nature 328, 596-600.
21. Yamada, O., Yu, M., Yee, J-K., Kraus, G., Looney, D., and Wong-Staal, F. (1994). Intracellular immunization of human T-cells with a hairpin ribozyme against human immunodeficiency virus type 1. Gene Therapy 1, 38-45.
22. Yu, M., Ojwang, J., Yamada, O., Hampel, A., Rappaport, J., Looney, D., and Wong-Staal, F. (1993). A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1. Proc Natl. Acad. Scl. USA 90, 6340-6344.
23. Yu, M., Poeschla, E., and Wong-Staal, F. (1994a). Progress towards gene therapy for HIV infection. Gene Therapy 1, 13-26.
24. Yu, M., Leavitt, M., Maruyama, M., Yamada, O., Young, D., Ho, A., and Wong-Staal, F. (1994b). Intracellular Immunization of Human Hematopoietic Stem/Progenitor Cells with a Ribozyme against HIV-1. J. Exp. Med., submitted for publication.