The mouse obese gene: Genomic organization, promoter activity, and activation by ccaat/enhancer-binding protein α

Journal of Biological Chemistry

Volumn 270, Issue 48, 1995, Pages 28887-28891

  He, Yufang ^a   Chen, Hui ^a,b   Quon, Michael J ^a,b   Reitman, Marc ^a,c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA BINDING PROTEIN; GENE PRODUCT; LUCIFERASE; MESSENGER RNA; TRANSCRIPTION FACTOR SP1;

ADIPOSE TISSUE CELL; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL STRAIN K 562; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; MOLECULAR CLONING; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; RESTRICTION MAPPING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOSE TISSUE; ALTERNATIVE SPLICING; ANIMAL; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CLONING, MOLECULAR; DNA; DNA PRIMERS; DNA-BINDING PROTEINS; EXONS; LEPTIN; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OBESITY; PROMOTER REGIONS (GENETICS); PROTEINS; RATS; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATION (GENETICS);

EID: 0028849084     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.270.48.28887     Document Type: Article

References (41)

1. Rink, T. J. (1994) Nature 372, 406-407
2. Hervey, G. R. (1959) J. Physiol. 145, 336-352
3. Harris, R. B. S., Kasser, T. R., and Martin, R. J. (1986) J. Nutr. 116, 2536-2546
4. Faust, I. M., Johnson, P. R., and Hirsch, J. (1977) Science 197, 393-396
5. Leibel, R. L., Rosenbaum, M., and Hirsch, J. (1995) N. Engl. J. Med. 332, 621-628
6. Stunkard, A. J., Harris, J. R., Pedersen, N. L., and McClearn, G. E. (1990) N. Engl. J. Med. 322, 1483-1487
7. Coleman, D. L. (1978) Diabetologia 14, 141-148
8. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. L. (1994) Nature 372, 425-432; Correction: (1995) Nature 374, 479
9. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., and Burn, P. (1995) Science 269, 546-549
10. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Hurley, S. K., and Friedman, J. M. (1995) Science 269, 543-546
11. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., and Collins, F. (1995) Science 269, 540-543
12. Altschul, S. F., Gish, W., Miller, W., Myers, E. W., and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410
13. Genetics Computer Group (1994) Program Manual for the Wisconsin Package, version 8, Genetics Computer Group, Madison, WI
14. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. (1995) Current Protocols in Molecular Biology, John Wiley & Sons, New York
15. Quon, M. J., Zarnowski, M. J., Guerre-Millo, M., de la Luz Sierra, M., Taylor, S. I., and Cushman, S. W. (1993) Biochem. Biophys. Res. Commun. 194, 338-46
16. Gorman, C. M., Merlino, G. T., Willingham, M. C., Pastan, I., and Howard, B. H. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 6777-6781
17. Neuman, J. R., Morency, C. A., and Russion, K. O. (1987) BioTechniques 5, 444-449
18. Taketo, M., Schroeder, A. C., Mobraaten, L. E., Gunning, K. B., Hanten, G., Fox, R. R., Roderick, T. H., Stewart, C. L., Lilly, F., Hansen, C. T., and Overbeek, P. A. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 2065-2069
19. Kadonaga, J. T., Jones, K. A., and Tjian, R. (1986) Trends Biochem. Sci. 11, 20-23
20. Johnson, P. (1993) Mol. Cell. Biol. 13, 6919-6930
21. Murakami, T., and Shima, K. (1995) Biochem. Biophys. Res. Commun. 209, 944-952
22. Lozzio, C. B., and Lozzio, B. B. (1975) Blood 45, 321-334
23. Freytag, S. O., Paielli, D. L., and Gilbert, J. D. (1994) Genes & Dev. 8, 1654-1663
24. Lin, F.-T., and Lane, M. D. (1994) Proc. Natl. Acad. Sci. U. S. A. 61, 8757-8761
25. Christy, R. J., Yang, V. W., Ntambi, J. M., Geiman, D. E., Landschutz, W. H., Friedman, A. D., Nakabeppu, Y., Kelly, T. J., and Lane, M. D. (1989) Genes & Dev. 3, 1323-1335
26. Herrera, R., Ro, H.-S., Robinson, G. S. Xanthopoulos, K. G., and Spiegelman, B. M. (1989) Mol. Cell. Biol. 9, 5331-5339
27. McKnight, S. L., Lane, M. D., and Gluecksohn, W. S. (1989) Genes & Dev. 3, 2021-2024
28. Clarke, S. D., and Abraham, S. (1992) FASEB J. 6, 3146-3152
29. MacDougald, O. A., and Lane, M. D. (1995) Annu. Rev. Biochem. 64, 345-373
30. Spiegelman, B. M., Choy, L., Hotamisligil, G. S., Graves, R. A., and Tontonoz, P. (1993) J. Biol. Chem. 268, 6823-6826
31. Alexander-Bridges, M., Dugast, I., Ercolani, L., Kong, X. F., Giere, L., and Nasrin, N. (1992) Adv. Enzyme Regul. 32, 149-159
32. Moustaid, N., Beyer, R. S., and Sul, H. S. (1994) J. Biol. Chem. 269, 5629-5634
33. Shih, H.-m., and Towle, H. C. (1994) J. Biol. Chem. 269, 9380-9387
34. Ntambi, J. M. (1992) J. Biol. Chem. 267, 10925-10930
35. O'Brien, R. M., Lucas, P. C., Yamasaki, T., Noisin, E. L., and Granner, D. K. (1994) J. Biol. Chem. 269, 30419-30428
36. Considine, R. V., Considine, E. L., Williams, C. J., Nyce, M. R., Magosin, S. A., Bauer, T. L., Rosato, E. L., Colberg, J., and Caro, J. F. (1995) J. Clin. Invest. 95, 2986-2988
37. Liimatta, M., Towle, H. C., Clarke, S., and Jump, D. B. (1994) Mol. Endo. 8, 1147-1153
38. Blake, W. L., and Clarke, S. L. (1990) J. Nutr. 120, 1727-1729
39. Wang, X., Sato, R., Brown, M. S., Hua, X., and Goldstein, J. L. (1994) Cell 77, 53-62
40. Lehman, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995) J. Biol. Chem. 270, 12953-12956
41. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Cell 79, 1147-1156