Immunophenotypic and DNA genotypic analysis of t-cell and NK-cell subpopulations in patients with b-cell chronic lymphocytic leukaemia (b-CLL)

Leukemia and Lymphoma

Volumn 16, Issue 3-4, 1995, Pages 307-318

  Frolova, Elena A ^a   Richards, Stephen J ^a   Jones, Richard A ^a   Rawstron, Andrew ^a   Master, Peter S ^a   Teasdale, Jane ^a   Short, Michael ^a   Jack, Andrew S ^a   Scott, Colin Stephen ^a  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

B CLL; CD45R; Immunophenotypes; NK cells; PCR analysis; T cells

Indexed keywords

CD16 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; CELL DNA;

ADULT; AGED; ARTICLE; B CELL LEUKEMIA; CELL MEMBRANE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MALE; NATURAL KILLER CELL; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE;

AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD45; BASE SEQUENCE; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, LEUKEMIC; GENOTYPE; HLA-DR ANTIGENS; HUMAN; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; LEUKEMIA, B-CELL, CHRONIC; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0028847881     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199509049770     Document Type: Article

References (35)

1. Clinical significance of T cells in chronic lymphocytic leukaemia
2. T-cell subpopulations in chronic lymphocytic leukaemia: Abnormalities in distribution and in vitro maturation
3. Biology of chronic lymphocytic leukaemia
4. T-cell activation and subset patterns are altered in B-CLL and correlate with the stage of the disease
5. Immunoregulatory T cells in B cell chronic lymphocytic leukaemia: Evidence of a unique phenotype; a flow cytometry study
6. An analysis of circulating CD4 lymphocyte sub-populations in B-cell chronic lymphocytic leukaemia
7. The cellular basis for the induction of antigen-specific T8 suppressor cells
8. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells
9. The functionally distinct subpopulations of human CD4+ helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation
10. Pheno-typic changes in a CD4+ lymphocyte subset correlate with a conversion from suppressor to helper inducer function
11. Phenotypic changes associated with activation of CD45RA+ and CD45RO+ T cells
12. Differential activation requirement for virgin and memory T cells
13. Selective loss of CD4+ CD45R+ T cells in peripheral blood of multiple myeloma patients
14. Cellular events during memory T-cell activation in vitro: the UCHL1 (180,000 MW) determinant is newly synthesized after mitosis
15. Immunophenotypic dissection of normal peripheral blood NK associated (NKa) subpopulations by flow cytometry: Morphological features and relationships between membrane NKa (CD11b, CD16, CD56 and CD57) and T-cell (CD2, CD3, TCR, CD5, CD7, CD8 and CD38) associated determinant expression
16. Relationships between 2H4 (CD45RA) and UCHL1 (CD45RO) expression by normal blood CD4+CD8-, CD4-CD8+, CD4-CD8dim+, CD3+CD4-CD8- and CD3-CD4-CD8- lymphocytes
17. Autoimmunity in chronic lymphocytic leukaemia
18. Defective T cell responsiveness in chronic lymphocytic leukemia: Analysis of activation events
19. Defective helper function of purified T4 cells and excessive suppressor activity of purified T8 cells in patients with B-cell chronic lymphocytic leukemia: T4 suppressor effector cells are present in certain patients
20. Lack of prognostic significance of T lymphocyte subset counts in B-cell chronic lymphocytic leukaemia
21. Phenotypic characterization of the post-thymic differentiation of human alloantigen-specific CD8+ cytotoxic T lymphocytes
22. Interconversion of CD45R subsets of CD4 T cells in vivo
23. Loss of activation-induced CD45RO with maintenance of CD45RA expression during prolonged culture of T cells and NK cells
24. In the mouse, the maturation stage of the peripheral CD4+CD45RA+ subset is different from that of the CD8+CD45RA+ subset
25. Phenotypic switch from CD45RA+ to CD45RA- by normal blood T cells is associated with increased HLA-ABC expression for CD4+ and CD8+ populations but not for the NK-associated CD4-CD8dim+ or CD4-CD8- fractions
26. Human naive and memory T cells: Reinterpretation of helper-inducer and suppressor-inducer subsets
27. Decreased CD45RA T cells in B-cell chronic lymphatic leukemia patients: Correlation with disease stage
28. T cells and CD45R expression in B-chronic lymphocytic leukemia
29. Selective loss of the suppressor-inducer T cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody
30. A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody
31. Deficiency of the suppressor inducer subset of T lymphocytes in Rheumatoid Arthritis
32. Abnormalities in CD4+ T-lymphocyte subsets in inflammatory Rheumatic diseases
33. Defective expression of the 2H4 molecule after autologous mixed lymphocyte reaction activation in systemic lupus erythematosus patients
34. Immunomod-ulation by methmazole therapy for Graves disease. Rapid changes in regulatory T cell subsets, activated B cells and NK cells
35. CD45RA expression by CD4 T lymphocytes in tumors invaded by B-cell Non-Hodgkins lymphoma (NHL) or Hodgkins disease (HD)