Deriving the therapeutic concentrations for clozapine and haloperidol: The apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand

European Journal of Pharmacology: Molecular Pharmacology

Volumn 291, Issue 2, 1995, Pages 59-66

  Seeman, Philip ^a   Van Tol, Hubert H M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Antipsychotic drug; Dopamine D2 receptor; Dopamine D4 receptor; Nemonapride; Raclopride

Indexed keywords

3 (2 FLUOROETHYL)SPIPERONE; 3 FLUOROMETHYLSPIPERONE; CHLORPROMAZINE; CLOZAPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; EMONAPRIDE; EPIDEPRIDE; FLUORINE 18; HALOPERIDOL; LOXAPINE; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; RACLOPRIDE; RADIOLIGAND; RECEPTOR SUBTYPE; RISPERIDONE; SPIPERONE; THIORIDAZINE; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; CORPUS STRIATUM; DISSOCIATION CONSTANT; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; SWINE;

ANIMAL; BINDING, COMPETITIVE; CAUDATE NUCLEUS; CLOZAPINE; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; HUMAN; PITUITARY GLAND; RACLOPRIDE; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; SALICYLAMIDES; SUPPORT, NON-U.S. GOV'T; SWINE;

EID: 0028847305     PISSN: 09224106     EISSN: None     Source Type: Journal    
DOI: 10.1016/0922-4106(95)90125-6     Document Type: Article

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