Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Nature Medicine

Volumn 1, Issue 10, 1995, Pages 1046-1051

  Pisha, Emily ^a   Chai, Heebyung ^a   Lee, Ik Soo ^a   Chagwedera, Tangai E ^b   Farnsworth, Norman R ^a   Cordell, Geoffrey A ^a   Beecher, Christopher W W ^a   Fong, Harry H S ^a   Kinghorn, A Douglas ^a   Brown, Daniel M ^c,e   Wani, Mansukh C ^c   Wall, Monroe E ^c   Hieken, Tina J ^d   Gupta, Tapas K Das ^d   Pezzuto, John M ^a,d  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ZIMBABWE   (Zimbabwe)

^c RTI INTERNATIONAL   (United States)

^d UNIVERSITY OF ILLINOIS   (United States)

^e BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETULIC ACID; CAMPTOTHECIN; ELLIPTICINE; HOMOHARRINGTONINE; MITHRAMYCIN A; PACLITAXEL; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MELANOMA; MOUSE; PRIORITY JOURNAL;

ANIMAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; DNA DAMAGE; GROWTH INHIBITORS; GUANIDINES; HUMAN; LIVER NEOPLASMS; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MICE, NUDE; PUTRESCINE; SKIN NEOPLASMS; SUPPORT, U.S. GOV'T, P.H.S.; TRITERPENES; TUMOR CELLS, CULTURED;

ANIMALIA; BETULA PENDULA;

EID: 0028847024     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1095-1046     Document Type: Article

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