Integrin mediated signal transduction in oncogenesis: An overview

Cancer and Metastasis Reviews

Volumn 14, Issue 3, 1995, Pages 165-172

  Dedhar, Shoukat ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

anchorage dependent growth; apoptosis; integrins; kinases; metastasis; signal transduction

Indexed keywords

INTEGRIN;

CARCINOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMAL; HUMAN; INTEGRINS; MOLECULAR SEQUENCE DATA; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 0028846140     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/BF00690289     Document Type: Article

References (59)

1. Integrins: versatility, modulation, and signaling in cell adhesion
2. Integrin-mediated adhesion and signalling in tumorigenesis
3. Integrins and signal transduction pathways: the road taken
4. Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin α-subunit-binding protein
5. Novel functions for calreticulin: interaction with integrins and modulation of gene expression?
6. Synergeistic roles for receptor occupancy and aggregation in integrin transmembrane function
7. Fibronectin inhibits the terminal differentiation of human keratinocytes
8. Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation
9. Signal transduction via the β integrins is a required intermediate in interleukin-1 induced phenotypic differentiation of human osteosarcoma cells
10. The osteoblastlike differentiated phenotype of a variant of human MG-63 osteosarcoma cell line correlated with altred adhesive properties
11. Differential regulation of expression of specific integrin receptors by nerve growth factor and transforming growth factor β during differentiation of human neuroblastoma cells
12. Signal transduction through the fibronectin receptor induces collagenase and stromeysin gene expression
13. Apoptosis induced by inhibition of intercellular contact
14. Disruption of epithelial cell-matrix interactions induces apoptosis
15. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
16. The extracellular matrix as a survival factor
17. A link between cyclin A expression and adhesion-dependent cell cycle progression
18. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
19. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development
20. Embryonic mesodermal defects in α5 integrin-deficient mice
21. Costimulation of proliferative responses of resting CD4 and T cells by interaction of VLA4 and VLA5 with fibronectin or VLA6 with laminin
22. VLA-4 mediates CD3-dependent CD4+ T-cells activation via the CSI alternatively spliced domain of fibronectin
23. Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, but not ELAM-1
24. Roles of multiple accessing molecules in T-cell activation
25. Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction
26. Insoluble fibronectin activates the Na+/H+ antiporter by clustering and immobilizing integrin α5β1, independent of cell shape
27. Signal transduction from the extracellular matrix
28. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120 kDa protein
29. Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins
30. Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated α2β1 integrin activation in T-lymphoblastic cells
31. Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly
32. pp125FAK, as structurally distinctive proteintyrosine kinase associated with focal adhesions
33. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion associated tyrosine kinase
34. Regulation of focal adhesion associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
35. Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of α3 and α6 integrins
36. Integrinmediated cell adhesion activates mitogen-activated protein kinases
37. Integrin-mediated signal transduction linked to ras pathway by GRB-2 binding to focal adhesion kinase
38. Association of the Shc and Grb2/sems SH2 containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
39. The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes
40. The small GTP-binding protein rho regulates the asembly of focal adhesions and actin stress fibers in response to growth factors
41. The amino terminal region of GAP regulates cytoskeletal structure and cell adhesion
42. Bombesin, vasopresin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate
43. ADP-ribosylation of Rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in Swiss 3T3 cells
44. Association of insulin receptor substrate-1 with integrins
45. In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (Calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin α subunits
46. Inhibition of nuclear hormone receptor activity by calreticulin
47. Integrins and tumor invasion
48. Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes
49. In vitro and in vivo consequences of VLA-2 expression on rhabdamyosarcoma cells
50. Integrin distribution in malignant melanomas: association of the β3 subunit with tumor progression
51. Involvement of αv gene expression in human melanoma tumorigenesis
52. Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
53. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
54. Expression of focal adhesion kinase gene and invasive cancer
55. Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase
56. Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras family
57. Identification of an invasion-inducing gene Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins