Role of microtubule-associated proteins in the control of microtubule assembly

Physiological Reviews

Volumn 75, Issue 4, 1995, Pages 835-864

  Maccioni, Ricardo B ^a   Cambiazo, Verónica ^a  

^a Intl Ctr for Cancer and Devmtl B   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

BIK 1; CYTOPLASM PROTEIN; DYNEIN ASSOCIATED PROTEIN; FUNGAL PROTEIN; GEPHYRIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 2; MICROTUBULE INTERACTING PROTEIN; NUCLEAR PROTEIN; PROTEIN P 150; RECEPTOR PROTEIN; RNA; TAU PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ALTERNATIVE RNA SPLICING; ARTICLE; CYTOSKELETON; DROSOPHILA MELANOGASTER; ECHINODERM; HUMAN; INTERMEDIATE FILAMENT; MICROTUBULE ASSEMBLY; MITOSIS; NONHUMAN; PLANT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SQUID; TRYPANOSOMA BRUCEI; XENOPUS;

EID: 0028845388     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.1995.75.4.835     Document Type: Article

References (348)

1. AAMODT, E. J., AND R. C. WILLIAMS. Microtubule-associated proteins connect microtubules and neurofilaments in vitro. Biochemistry 23: 6023-6031, 1984.
2. ADEREM, A. Signal transduction and the actin cytoskeleton: the roles of MARCKS and Profilin. Trends Biochem. Sci. 17: 438-443, 1992.
3. AIZAWA, H., Y. EMORI, A. MORI, H. MUROFOSHI, H. SAKAI, AND K. SUZUKI. Functional analyses of the domain structure of microtubuleassociated protein-4 (MAP-U). J. Biol. Chem. 266: 9841-9846, 1991.
4. r fragment which stimulates microtubule assembly. J. Biol. Chem. 262: 3782-3787, 1988.
5. AIZAWA, H., H. KAWASAKI, H. MUROFUSHI, S. KOTANI, K. SUSUKI, AND H. SAKAI. Microtubule binding domain of tau proteins. J. Biol. Chem. 263: 7703-7707, 1988.
6. AIZAWA, H., H. KAWASAKI, H. MUROFUSHI, S. KOTANI, K. SUSUKI, AND H. SAKAI. A common amino acid sequence in 190-kDa microtubule-associated protein and tau for the promotion of microtubule assembly. J. Biol. Chem. 264: 5885-5890, 1989.
7. ALETTA, J. M., AND L. A. GREENE. Sequential phosphorylation of chartin microtubule-associated proteins is regulated by the presence of microtubules. J. Cell Biol. 105: 277-285, 1987.
8. ALLAN, V. J., AND T. E. KREIS. A microtubule-binding protein associated with membranes of the Golgi apparatus. J. Cell Biol. 103: 2229-2239, 1986.
9. AMOS, L. A. Arrangement of high-molecular weight associated proteins on purified mammalian brain microtubules. J. Cell Biol. 72: 642-654, 1977.
10. AMOS, L. A., AND T. S. BAKER. The three-dimensional structure of tubulin protofilaments. Nature Lond. 279: 607-612, 1979.
11. ANDREASSEN, P. R., D. K. PALMER, M. H. WENER, AND R. L. MARGOLIS. Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis. J. Cell Sci. 99: 523-534, 1991.
12. ANIELLO, F., D. COUCHIE, A. BRIDOUX, D. GRIPOIS, AND J. NUNEZ. The splicing of juvenile and adult tau mRNA variant is regulated by thyroid hormone. Proc. Natl. Acad. Sci. USA 88: 4035-4038, 1991.
13. ARGARANA, C. E., H. S. BARRA, AND R. CAPUTTO. Tubulinyltyrosine carboxypeptidase from chicken brain: properties and partial purification. J. Neurochem. 34: 114-118, 1980.
14. ASAI, D. J., W. THOMPSON, L. WILSON, C. F. DRESDEN, H. SCHULMAN, AND D. L. PURICH. Microtubule-associated proteins: a monoclonal antibody to MAP-1 decorates microtubules in vitro but stains stress fibers and not microtubules in vivo. Proc. Natl. Acad. Sci. USA 82: 1434-1436, 1985.
15. BALCZON, R., AND K. WEST. The identification of mammalian centrosomal antigens using human autoimmune anticentrosome antisera. Cell Motil. Cytoskeleton 20: 121-135, 1991.
16. BARON, A. T., AND J. L. SALISBURY. Identification and localization of a novel, cytoskeletal, centrosome-associated protein in PtKa cells. J. Cell Biol. 107: 2669-2678, 1988.
17. BARRA, H. S., C. A. ARCE, J. A. RODRIGUEZ, AND R. CAPUTTO. Some common properties of the protein that incorporates tyrosine as a single unit and the microtubule proteins. Biochem. Biophys. Res. Commun. 60: 1384-1390, 1974.
18. BASS, P. W., T. P. PIENKOWSKI, AND K. S. KOSIK. Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization. J. Cell Biol 115: 1333-1344, 1991.
19. BAUDIER, J., AND D. COLE. Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin dependent kinase and modulated by phospholipids. J. Biol. Chem. 262: 17577-17583, 1987.
20. BENNET, V., AND J. DAVIS. Erythrocyte ankyrin: immunoreactive analogues are associated with mitotic structures in cultured cells and with microtubules in brain. Proc. Natl. Acad. Sci. USA 78: 7550-7554, 1981.
21. BERLIN, V., C. A. STYLES, AND G. R. FINK. BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. J. Cell Biol. 11: 2573-2586, 1990.
22. BERLING, B., H. WILLE, B. ROLL, E. M. MANDELKOW, C. GRANER, AND E. MANDELKOW. Phosphorylation of microtubule-associated proteins MAP2a, b and MAP2c at Ser 136 by proline-directed kinase in vivo and in vitro. Eur. J. Cell Biol. 64: 120-130, 1994.
23. BERNHARDT, R., G. HUBER, AND A. MATUS. Differences in the developmental patterns of microtubule associated proteins in the rat cerebellum. J. Neurosci. 5: 977-991, 1985.
24. BERNHARDT, R., AND A. MATUS. Light and electron microscopic studies of the distribution of microtubule-associated protein 2 in rat brain: a difference between dendritic and axonal cytoskeletons. J. Comp. Neurol. 226: 203-221, 1984.
25. BERSHADSKY, A. D., AND J. VASLIEV. Cytoskeleton. New York: Plenum, 1988.
26. BERSHADSKY, A. D., AND J. VASILIEV. Factors controlling the distribution of pseudopods: reorganization of microtubules. In: Cytoskeleton, edited by P. Siekvitz. New York: Plenum, 1988, p. 238-242.
27. BIERNAT, J., N. GUSKE, G. DREWES, E. M. MANDELKOW, AND E. MANDELKOW. Phosphorylation of ser262 strongly reduces binding of tau to microtubules: distinction between phf-like immunoreactivity and microtubule binding. Neuron 11: 153-163, 1993.
28. BILBE, G., J. DELABIE, J. BRUGEN, H. RICHENER, F. A. ASSELBERGS, N. CERLETTI, C. SORG, K. ODINK, L. TARCSAY, AND W. WIESENDANGER. Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease. EMBO J. 11: 2103-2113, 1992.
29. BINDER, L. I., A. FRANKFURTER, H. KIM, A. CACERES, M. R. PAYNE, AND L. I. REBHUN. Heterogeneity of microtubule-associated protein 2 during rat brain development. Proc. Natl. Acad. Sci. USA 81: 5613-5617, 1984.
30. BINDER, L. I., A. FRANKFURTER, AND L. REBHUN. The distribution of tau polypeptides in the mammalian nervous system. J. Cell Biol. 101: 1371-1378, 1985.
31. BINDER, L. I., AND L. I. REBHUN. The calcium sensitivity of MAP-2 and tau microtubules in the presence of calmodulin. In: Dynamic Aspects of Microtubule Biology, edited by D. Soifer. New York: NY Acad. Sci., 1986, p. 392-409.
32. BLACK, M., AND J. T. KURDYLA. Microtubule-associated proteins of neurons. J. Cell Biol. 97: 1020-1028, 1983.
33. BLOODGOOD, R. A., AND J. L. ROSENBAUM. Initiation of brain tubulin assembly by a high molecular weight flagellar protein factor. J. Cell Biol. 71: 322-331, 1976.
34. BLOOM, G., F. C. LUCA, AND R. B. VALLEE. Microtubule-associated protein IB: identification of a major component of neuronal cytoskeleton. Proc. Natl. Acad. Sci. USA 82: 5404-5408, 1985.
35. BLOOM, G. S., T. A. SCHOENFEL, AND R. B. VALLEE. Widespread distribution of the major polypeptide component of MAP 1 (microtubule-associated protein 1) in the nervous system. J. Cell Biol. 98: 320-330, 1984.
36. BLOOM, G. S., AND R. B. VALLEE. Association of microtubule associated protein 2 (MAP2) with microtubules and intermediate filaments in cultured brain cells. J. Cell Biol. 96: 847-831, 1983.
37. BLOSE, S. H., D. MELTTZER, AND J. FERAMISCO. 10-nm intermediate filaments induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin. J. Cell Biol. 98: 847-858, 1984.
38. BOND, J. F., G. S. ROBINSON, AND S. R. FARMER. Differential expression of two neural cell specific β-tubulin mRNAs during rat brain development. Mol. Cell. Biol. 4: 1313-1319, 1984.
39. BONIFACIO, J. S., R. D. KLAUSNER, AND I. V. SANDOVAL. A widely distributed nuclear protein immunologically related to MAP-1 is associated with the mitotic spindle. Proc. Natl. Acad. Sci. USA 82: 1146-1150, 1985.
40. BORISY, G. G., M. MARCUM, J. B. OLMSTED, D. B. MURPHY, AND K. A. JOHNSON. Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly. Ann. NY Acad. Sci. 253: 107-132, 1975.
41. BORGERS, M., AND M. DE BRABANDER. Microtubules and Microtubule Inhibitors. New York: Elsevier/North-Holland, 1975.
42. BOUCHER, D., J. C. LARCHER, F. GROSS, AND P. DENOULET. Polyglutamylation of tubulin as a progressive regulator of in vitro interactions between the microtubule-associated protein tau and tubulin. Biochemistry 33: 12471-12477, 1994.
43. BRADY, R. C., AND F. R. CABRAL. Identification of a 210 kDa microtubule associated protein in Chinese hamster ovary cells (Abstract). J. Cell Biol 101: 30a, 1985.
44. BRANDT, R., AND G. LEE. The balance between tau protein's microtubule growth and nucleation activities: implications for the formation of axonal microtubules. J. Neurochem. 61: 997-1004, 1989.
45. BRANDT, R., AND G. LEE. Functional organization of microtubule-associated protein tau. Identification of regions which affect microtubule growth, nucleation, and bundle formation in vitro. J. Biol. Chem. 268: 3414-3419, 1993.
46. r 205,000 sulfoglycoprotein in extracellular matrix of mouse fibroblasts immunologically related to high molecular weight microtubule associated proteins. Proc. Natl. Acad. Sci. USA 82: 5776-5780, 1985.
47. BROWN, A., Y. LI, T. SLAUGHTER, AND M. M. BLACK. Composite microtubules of the axon: quantitative analysis of tyrosinated and acetylated tubulin along individual axonal microtubules. J. Cell Sci. 104: 339-352, 1993.
48. BRUGG, B., AND A. MATUS. Phosphorylation determines the binding of microtubule-associated protein 2 (MAP-2) to microtubules in living cells. J. Cell. Biol. 114: 735-741, 1991.
49. BULINSKI, J., AND G. G. BORISY. Self-assembly of microtubules in extracts of cultured HeLa cells and the identification of HeLa microtubule-associated proteins. Proc. Natl. Acad. Sci. USA 76: 293-297, 1979.
50. BULINSKI, J., AND G. G. BORISY. Microtubule-associated proteins from cultured HeLa cells. Analysis of molecular properties and effects on microtubule polymerization. J. Biol. Chem. 255: 11570-11576, 1980.
51. BULINSKI, J., AND G. G. BORISY. Immunofluorescence localization of HeLa cell microtubule-associated proteins on microtubules in vitro and in vivo. J. Cell Biol. 87: 792-801, 1980.
52. BURGOYNE, R. D., AND R. CUMMING. Ontogeny of microtubule associated protein 2 in rat cerebellum: differential expression of the doublet polypeptides. Neuroscience 11: 156-167, 1984.
53. BURGOYNE, R. D., AND K. M. NORMAN. Presence of microtubule associated protein 2 in chromaffin cells. Neuroscience 14: 955-962, 1987.
54. BUTLER, M., AND M. L. SHELANSKI. Microheterogeneity of microtubule-associated tau proteins is due to differences in phosphorylation. J. Neurochem. 47: 1517-1522, 1986.
55. BUTNER, K. A., AND M. W. KIRSCHNER. Tau protein binds to microtubules through a flexible array of distributed weak sites. J. Cell Biol. 115: 717-730, 1991.
56. CACERES, A., G. A. BANKER, AND L. BINDER. Immunocytochemical localization of tubulin and microtubule-associated protein 2 during development of hippocampal neurons in culture. J. Neurosci. 6: 714-722, 1986.
57. CACERES, A., G. BANKER, O. STEWARD, L. BINDER, AND M. PAYNE. MAP2 is localized to the dendrites of hippocampal neurons which develop in culture. Dev. Brain Res. 13: 314-318, 1984.
58. CACERES, A., AND K. S. KOSIK. Inhibition of neurite polarity by tau anti-sense oligonucleotides in primary cerebellar neurons. Nature Lond. 343: 461-463, 1990.
59. CACERES, A., S. POTREBIC, AND K. S. KOSIK. The effects of tau anti-sense oligonucleotides on neurite formation of cultured cerebellar neurons. J. Neurosci. 11: 1515-1523, 1991.
60. CAMBIAZO, V., M. GONZALEZ, AND R. B. MACCIONI. Identification and characterization of a microtubule associated protein from Drosophila melanogaster (Abstract). Mol. Biol Cell 4: 265a, 1993.
61. CAMBIAZO, V., M. GONZALEZ, AND R. B. MACCIONI. DMAP-85: a tau-like protein from Drosophila melanogaster larvae. J. Neurochem. 64: 1288-1297, 1995.
62. CANN, J., E. YORK, J. STEWART, J. C. VERA, AND R. B. MACCIONI. Small zone gel chromatography of interacting systems: theoretical and experimental evaluation of elution profiles for kinetically controlled macromolecule-ligand reactions. Anal. Biochem. 175: 462-473, 1988.
63. CAPOTE, C., AND R. B. MACCIONI. Tau-mediated interactions between microtubules and vimentin filaments. Not. Biol. 2: 64-64, 1994.
64. CARLIER, M. F., C. SIMON, R. CASSOLY, AND L. A. PRADEL. Interaction between microtubule-associated protein tau and spectrin. Biochimie 66: 305-311, 1984.
65. CARRAWAY, K. L., M. PRATT, AND D. R. BURGESS. The cytoskeleton: past, present and future. Bioessays 7: 147-149, 1987.
66. CASIANO, C. A., G. LANDBERG, R. L. OCHS, AND E. M. TAN. Autoantibodies to a novel cell cycle-regulated protein that accumulates in the nuclear matrix during S phase and is localized in the kinetochores and spindle midzone during mitosis. J. Cell Sci. 106: 1045-1056, 1993.
67. CASSIMERIS, L. Regulation of microtubule dynamic instability. Cell Motil. Cytoskeleton 26: 275-281, 1993.
68. CHANG-JIE, J., AND S. SONOBE. Identification and preliminary characterization of a 65 kDa higher plant microtubule-associated protein. J. Cell Sci. 105: 891-901, 1993.
69. r. Microtubule-associated protein (MAP-4) contains a domain homologous to the microtubule-binding domain of neuronal MAP-2 and tau. J. Cell Sci. 98: 27-36, 1991.
70. CHEVRIER, V., S. KOMESLI, A.-C. SCHMIT, M. VANTARD, A.-M. LAMBERT, AND D. JOB. A monoclonal antibody, raised against mammalian centrosomes and screened by recognition of plant microtubule organizing centers, identifies a pericentriolar component in different cell types. J. Cell Sci. 101: 823-835, 1992.
71. CLARK, S. W., AND D. I. MEYER. Centractin is an actin homologue associated with the centrosome. Nature Lond. 359: 246-250, 1992.
72. CLEVELAND, D. W. The multitubulin hypothesis revisited: what have we learned? J. Cell Biol. 104: 381-383, 1987.
73. CLEVELAND, D. W. Microtubule mapping. Cell 60: 701-702, 1990.
74. CLEVELAND, D., S. Y. HWO, AND M. W. KIRSCHNER. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J. Mol. Biol. 116: 207-225, 1977.
75. CLEVELAND, D. W., S. Y. HWO, AND M. W. KIRSCHNER. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J. Mol. Biol. 116: 227-248, 1977.
76. COHEN, C., AND D. A. D. PARRY. α-Helical coiled-coil - a widespread motif in proteins. Trends Biochem. Sci. 11: 245-248, 1986.
77. COMPTON, D. A, I. SZILAK, AND D. W. CLEVELAND. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J. Cell Biol. 116: 1395-1408, 1992.
78. COMPTON, D. A., T. J. YEN, AND D. W. CLEVELAND. Identification of a novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffold. J. Cell Biol. 112: 1083-1097, 1991.
79. COOKE, C., M. S. HECK, AND W. C. EARNSHAW. The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis. J. Cell Biol. 105: 2053-2067, 1987.
80. COUCHIE, D., C. CHARRIERE-BERTRANDS, AND J. NUNEZ. Expression of mRNA for tau proteins during brain development and in cultured neurons and astroglial cells. J. Neurochem. 50: 1894-1897, 1988.
81. COUCHIE, D., C. MAVILIA, I. GEORGIEFF, R. LIEM, M. L. SHELANSKI, AND J. NUNEZ. Primary structure of high molecular weight tau present in the peripheral nervous system. Proc. Natl. Acad. Sci. USA 89: 4378-4381, 1992.
82. CROSS, D., J. DOMINGUEZ, R. MACCIONI, AND J. AVILA. MAP-1 and MAP-2 binding sites at the C-terminus of beta tubulin. Studies with synthetic tubulin peptides. Biochemistry 30: 4362-4366, 1991.
83. CROSS, D., G. FARIAS, J. DOMINGUEZ, J. AVILA, AND R. B. MACCIONI. Carboxyl-terminal sequences on β-tubulin involved in the interaction of HMW-MAPs. Studies using site-specific antibodies. Mol. Cell. Biochem. 132: 81-90, 1994.
84. CROSS, D., C. VIAL, AND R. B. MACCIONI. A tau-like protein interacts with stress fibers and microtubules in human and rodent cell lines. J. Cell Sci. 105: 51-60, 1993.
85. CYR, J. R. Calcium/calmodulin affects microtubule stability in lysed protoplasts. J. Cell Sci. 100: 311-317, 1991.
86. DAHLGREN, V., AND A. F. W. KEPNER. Principles of Animal Histology. New York: Macmillan, 1908.
87. DANOWSKI, B. Fibroblast contractility and actin organization are stimulated by microtubule inhibitors. J. Cell Sci. 93: 255-266, 1989.
88. DE BRABANDER, M., J. BULINSKI, G. GEUENS, J. DE MEY, AND G. BORISY. Immunoelectron microscopic localization of the 210,000-mol wt microtubule-associated protein in cultured cells of primates. J. Cell Biol. 91: 438-445, 1981.
89. DE BRABANDER, M., AND J. DE MAY. Microtubule and Microtubule Inhibitors. Amsterdam: Elsevier/North-Holland, 1980.
90. DEERY, W. J., A. R. MEANS, AND R. B. BRINKLEY. Calmodulinmicrotubule association in cultured mammalian cells. J. Cell Biol. 98: 904-910, 1984.
91. DIAZ-NIDO, J., L. SERRANO, E. MENDEZ, AND J. AVILA. A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell diferentiation. J. Cell Biol. 106: 2057-2065, 1988.
92. DINSMORE, J. H., AND F. SOLOMON. Inhibition of MAP-2 expression affects both morphological and cell division phenotypes of neuronal differentiation. Cell 64: 817-826, 1991.
93. DOLL, T., M. MEICHSNER, B. M. RIEDERER, P. HONEGGER, AND A. MATUS. An isoform of microtubule-associated protein 2 (MAP2) containing four repeats of the tubulin binding motif. J. Cell Sci. 106: 633-640, 1993.
94. DOMINGO, A., A. J. SARRIA, R. M. EVANS, AND M. W. KLYMKOWSKI. Studying intermediate filaments. In: The Cytoskeleton: A Practical Approach, edited by K. L. Carrway and C. A. A. Carraway. Oxford, UK: Oxford Univ. Press, 1992, p. 223-255.
95. DOMINGUEZ, J. E., B. BUENDIA, C. LOPEZ-ORTIN, C. ANTONY, E. KARSENTI, AND J. AVILA. A protein related to brain microtubule-associated protein MAP-1B is a component of the mammalian centrosome. J. Cell Sci. 107: 601-611, 1994.
96. DRAETTA, G. Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem. Sci. 15: 378-383, 1990.
97. DRESCHER, D. N., A. A. HYMAN, M. H. COBB, AND M. W. KIRSCHNER. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol. Biol. Cell. 3: 1141-1154, 1992.
98. DREWES, G., B. LICHTENBERG, F. DURING, E. M. MANDELKOW, J. BIERNAT, J. GORIS, M. DOREE, AND E. MANDELKOW. Mitogenactivated (MAP) kinase transforms tau proteins into an Alzheimerlike state. EMBO J. 11: 2131-2138, 1992.
99. DRUBIN, D. G., D. CAPUT, AND M. KIRSCHNER. Studies on the expression of the microtubule associated protein tau during mouse brain development, with newly isolated complementary cDNA probes. J. Cell Biol. 98: 1090-1097, 1984.
100. DRUBIN, D. G., S. C. FEINSTEIN, E. M. SHOOTER, AND M. W. KIRSCHNER. Nerve growth factor-induced neurite outgrowth in PC-12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J. Cell Biol. 101: 1799-1807, 1985.
101. DUERR, A., D. PALLAS, AND F. SOLOMON. Molecular analysis of cytoplasmic microtubules in situ: identification of both widespread and specific proteins. Cell 64: 203-211, 1981.
102. DUSTIN, P. Microtubules. Berlin: Springer-Verlag, 1984.
103. EARNSHAW, W. C., AND C. A COOKE. Analysis of the distribution of INCEPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation. J. Cell Sci. 98: 443-461, 1991.
104. EDDE, B., J. ROSSIER, J. LE CAER, E. DESBRUYERES, F. GROS, AND P. DENOULET. Postraslational glutamylation of α-tubulin. Science Wash. DC 247: 83-85, 1990.
105. ELLISMAN, M. H., AND K. R. PORTER. Microtubule structure of the axoplasmic matrix: visualization of cross-linking structures and their distribution. J. Cell Biol. 87: 467-479, 1980.
106. ENNULAT, D. J., R. K. H. LIEM, G. A. HASHIM, AND M. L. SHELANSKI. Two separate 18-amino-acid domains of tau promote polymerization of tubulin. J. Biol. Chem. 264: 5327-5330, 1989.
107. ESMAELI-AZAD, B., J. H. McCARTY, AND S. C. FEINSTEIN. Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neunte outgrowth and neurite stability. J. Cell Sci, 107: 869-879, 1994.
108. FARIAS, G., C. VIAL, AND R. B. MACCIONI. Specific macromolecular interactions between tau and the microtubule system. Mol. Cell. Biochem. 112: 81-88, 1992.
109. FARIAS, G., C. VIAL, AND R. B. MACCIONI. Functional domains on chemically modified tau protein. Cell. Mol. Neurobiol. 13: 173-182, 1993.
110. FAWCETT, D. W., W. A. ANDERSON, AND D. M. PHILLIPS. Morphogenetic factors influencing the shape of the sperm head. Dev. Biol. 26: 220-251, 1971.
111. FIELD, S., AND O. K. SONG. A novel genetic system to detect protein-protein interactions. Nature Lond. 340: 245-246, 1989.
112. FULLER, M. T., C. L. REGAN, L. L. GREEN, B. ROBERTSON, R. DEURING, AND T. S. HAYS. Interacting genes identify interacting proteins involved in microtubule function in Drosophila. Cell Motil. Cytosekeleton 14: 128-135, 1989.
113. FULTON, A. B. The Cytoskeleton: Cellular Architecture and Choreography. New York: Chapman and Hall, 1984.
114. FULTON, C., AND P. A. SIMPSON. The multitubulin hypothesis. Selective synthesis and utilization of flagellar alpha tubulin. In: Cell Motility, edited by R. Goldman, T. Pollard, and J. Rosenbaum. Cold Spring Harbor, NY: Cold Spring Harbor, 1976, p. 987-1005.
115. GACHE, Y., J. GUILLEMINOT, AND J. NUNEZ. High molecular weight tau distribution and microtubule stability in neuroblastoma N115 cells. Exp. Brain Res. 100: 267-275, 1994.
116. GASKIN, F., C. R. CANTOR, AND N. C. SHELANSKI. Turbidimetric studies of the in vitro assembly and disassembly of microtubules. J. Mol. Biol. 89: 736-773, 1974.
117. GARD, D. L., AND M. W. KIRSCHNER. A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end. J. Cell Biol. 105: 2203-2215, 1987.
118. GAREN, S. H., AND D. R. KANKEL. Golgi and genetic mosaic analysis of visual system mutants in Drosophila melanogaster. Dev. Biol. 96: 445-466, 1983.
119. GARNER, M., A. GARNER, G. HUBER, C. KOSAK, AND A. MATUS. Molecular cloning of microtubule-associated protein 1 (MAP-1A) and microtubule-associated proteins 5 (MAP-1B): identification of distinct genes and their differential expression in developing brain. J. Neurochem. 55: 146-154, 1990.
120. GARNER, C. C., AND A. MATUS. Different forms of microtubule-associated protein 2 are encoded by separate mRNA transcripts. J. Cell Biol. 106: 779-783, 1988.
121. GELFAND, J. F., AND A. BERSHADSKY. Microtubule dynamics: mechanism, regulation and function. Annu. Rev. Cell Biol, 7: 93-116, 1991.
122. GEORGIEFF, I. S., R. K. H. LIEM, W. MELLADO, J. NUNEZ, AND M. L. SHELANSKI. High molecular weight tau: preferential localization in the peripheral nervous system. J. Cell Sci. 100: 55-60, 1991.
123. GILBERT, S. P., AND R. D. SLOBODA. Identification of a MAP2-like ATP-binding protein associated with axoplasmic vesicles that translocate on isolated microtubules. J. Cell Biol. 103:847-956, 1989.
124. GILL, S. R., T. A. SCHROER, I. SZILAK, E. R. STUER, M. P. SHEETZ, AND D. W. CLEVELAND. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J. Cell Biol. 115: 1639-1650, 1991.
125. GINZBURG, I. Neuronal polarity: targeting of microtubule components into axons and dendrites. Trends Biochem. Sci. 16: 257-261, 1991.
126. GOEDERT, M., AND R. JAKES. Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J. 9: 4225-4230, 1990.
127. GOEDERT, M., M. G. SPILLANTINI, AND R. A. CROWTHER. Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system. Proc. Natl. Acad. Sci. USA 89: 1983-1987, 1992.
128. GOEDERT, M., M. SPILLANTINI, M. POTIER, J. ULRICH, AND R. CROWTHER. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J. 8: 393-399, 1989.
129. GOEDERT, M., C. M. WISCHIK, R. A. CROWTHER, J. E. WALKER, AND A. KLUG. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filaments of Alzheimer's disease. Identification as microtubule-associated protein tau. Proc. Natl. Acad. Sci. USA 85: 4051-4055, 1988.
130. GOLDSTEIN, L. S. B., R. A. LAYMON, AND J. J. McINTOSH. A microtubule-associated protein from Drosophila melanogaster. Identification, characterization, and isolation of coding sequences. J. Cell Biol. 102: 2076-2087, 1986.
131. GONZALEZ, M., V. CAMBIAZO, AND R. B. MACCIONI. Mip-90, a novel microtubule interacting protein in cultured cells (Abstract). Mol. Biol. Cell. 4: 293, 1993.
132. GONZALEZ, M., V. CAMBIAZO, AND R. B. MACCIONI. Identification of a new microtubule interacting protein Mip-90. Eur. J. Cell. Biol. 67: 158-169, 1995.
133. GOODE, B., AND S. C. FEINSTEIN. Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau. J. Cell Biol. 124: 769-782, 1994.
134. GRAHAM, D., F. PFEIFFER, R. SIMLER, AND H. BETZ. Purification and characterization of the glycine receptor of pig spinal cord. Biochemistry 24: 990-994, 1985.
135. GRIFFITH, L. M., AND T. D. POLLARD. Evidence for actin filaments - microtubule interaction mediated by microtubule-associated proteins. J. Cell Biol. 76: 958-965, 1978.
136. GRUNDKE-IQBAL, I., K. IQBAL, Y. TUNG, M. QUINLAN, H. WISNIEWSKI, AND L. BINDER. Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. USA 83: 4913-4917, 1986.
137. GUNDERSEN, G. G., M. H. KALNOSKI, AND J. C. BULINSKI. Distinct populations of microtubules: tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo. Cell 38: 779-789, 1984.
138. GUSTKE, N., B. TRINCZEK, J. BIERNAT, E. M. MANDELKOW, AND E. MANDELKOW. Domains of tau protein and interactions with microtubules. Biochemistry 33: 9511-9522, 1994.
139. GUZMAN, L., R. BUSTOS, AND R. B. MACCIONI. Purification and characterization of the high molecular weight microtubule associated proteins from neonatal rat brain. Mol. Cell. Biochem. 131: 105-113, 1994.
140. HALPAIN, S., AND P. GREENGARD. Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP-2. Neuron 5: 237-246, 1990.
141. HAMMARBACK, J. A., R. OBAR, S. HUGHES, AND R. B. VALLEE. MAP-1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule binding domain. Neuron 7: 129-139, 1991.
142. HARADA, A., K. OGUCHI, S. OKABE, J. KUNO, S. TERADA, T. OHSHIMA, R. SATO-YOSHITAKE, Y. TAKEI, T. NODA, AND N. HIROKAWA. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature Lond. 369: 488-491, 1994.
143. HARTE, P. J., AND D. R. KANKEL. Genetic analysis of mutation at the Glued locus and interacting loci in Drosophila melanogaster. Genetics 101: 477-501, 1982.
144. HEINMANN, R., M. L. SHELANSKI, AND R. LIEM. Microtubule associated proteins bind specifically to the 70 kDa neurofilament protein. J. Biol. Chem. 260: 12160-12166, 1985.
145. HEMPHILL, A., D. LAWSON, AND T. SEEBECK. The Trypanosoma brucei cytoskeleton: ultrastructure and localization of microtubule-associated and spectrin-like proteins using quick-freeze, deep-etch, immunogold electron microscopy. J. Struct. Biol. 107: 211-220, 1991.
146. HENRIQUEZ, J. P., D. CROSS, C. VIAL, AND R. B. MACCIONI. Subpopulations of tau interact with microtubules and actin filaments in diffent cell types. Cell Biochem. Funct. In press.
147. HERRMAN, H., J. DALTON, AND G. WICHE. Microheterogeneity of microtubule-associated proteins, MAP-1A and MAP-2, and differential phosphorylation of individual subcomponents. J. Biol. Chem. 260: 5759-5803, 1985.
148. HERZOG, W., AND K. WEBER. In vitro assembly of pure tubulin into microtubules in absence of microtubule-associated proteins and glycerol. Proc. Natl. Acad. Sci. USA 74: 1860-1864, 1977.
149. HERZOG, W., AND K. WEBER. Fractionation of brain microtubule-associated proteins. Isolation of two different proteins which stimulate tubulin polymerization in vitro. Eur. J. Biochem. 92: 1-8, 1978.
150. HIMMLER, A., D. DRECHSEL, M. KIRSCHNER, AND D. MARTIN. Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Mol. Cell. Biol. 9: 1381-1388, 1989.
151. HIROKAWA, K., Y. SHIOMURA, AND S. OKABE. Tau proteins: the molecular structure and mode of binding on microtubules. J. Cell Biol. 107: 1449-1459, 1988.
152. HIROKAWA, N., AND S.-I. HISANAGA. Buttonin, a unique buttonshaped microtubule-associated protein (75 kD) that decorates spindle microtubule surface hexagonally. J. Cell Biol. 104: 1553-1561, 1987.
153. HOLZBAUR, E. L. F., J. A. HAMMARBACK, B. M. PASCHAL, N. G. KRAVIT, K. K. PFISTER, AND R. B. VALLEE. Homology of a 150 K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued. Nature Lond. 351: 579-583, 1990.
154. HOSHI, M., E. NISHIDA, Y. MIYATA, H. SAKAI, T. MTYOSHI, H. OGAWARA, AND T. AKIYAMA. Protein kinase C phosphorylates tau and induces its functional alterations. FEBS Lett. 217: 237-241, 1987.
155. HOSOYA, N., H. HOSOYA, T. MOHRI, AND H. MOHRI. A 70 kD microtubule-binding protein from starfish eggs: purification, characterization, and localization during meiosis and mitosis. Cell Motil. Cytoskeleton 15: 168-180, 1990.
156. HUBER, G., D. ALAIMO-BEURET, AND A. MATUS. MAP-3: characterization of a novel microtubule-associated protein. J. Cell Biol. 100: 496-507, 1985.
157. HUGDAHL, J., C. BOKROS, V. HANESWORTH, G. R. AAULAND, AND L. C. MOREJOHN. Unique functional characteristics of the polymerization and MAP binding regulatory domains of plant tubulin. Plant Cell 5: 1063-1080, 1993.
158. IRMINGER-FINGER, I., R. A. LAYMON, AND L. S. B. GOLDSTEIN. Analysis of the primary sequence and microtubule-binding region of the Drosophila 205K MAP. J. Cell Biol. 11: 2563-2572, 1990.
159. IZANT, J. G., AND R. McINTOSH. Microtubule associated proteins: a monoclonal antibody to brain microtubule associated protein 2 binds to differentiated neurons. Proc. Natl. Acad. Sci. USA 77: 4741-4745, 1980.
160. JERNE, N. K. Recurrent idiotypes and internal images. EMBO J. 1: 243-247, 1982.
161. JIMENEZ, J., AND C. GODAY. A centrosome-associated antibody from Drosophila melanogaster reveals a new microtubule-dependent structure in equatorial zone of Parascaris univalens embryos. J. Cell Sci. 106: 719-730, 1993.
162. JOLY, J. C., G. FLYNN, AND D. L. PURICH. The microtubule-binding fragment of microtubule-associated protein-2: localization of the protease accessible site and identification of an assembly promoting peptide. J. Cell Biol. 109: 2289-2294, 1989.
163. JOSHI, H. C. γ-Tubulin: the Hub of cellular microtubule assemblies. Bioessays 15: 637-643, 1993.
164. JOSWIG, G., C. PETZEL, AND D. WERNER. Murine cDNAs coding for the centrosomal antigen centrosomin A J. Cell Sci. 98: 37-44, 1991.
165. JULIAN, M., Y. TOLLON, I. LAJOIE-MASENT, A. MOISAND, H. MAZARGUIL, A. PUGET, AND M. WRIGHT. γ-Tubulin participates in the formation of the midbody during cytokinesis in mammalian cells. J. Cell Sci. 105: 145-156, 1993.
166. KALLAJOKI, M., K. WEBER, AND M. OSBORN. A 210 kDa nuclear matrix protein is a functional part of the mitotic spindle: a microinjection study using SPN monoclonal antibodies. EMBO J. 10: 3351-3362, 1991.
167. KALLAJOKI, M., K. WEBER, AND M. OSBORN. Ability to organize microtubules in taxol-treated mitotic PtK2 cells goes with the SPN antigen and not with the centrosome. J. Cell Sci. 102: 91-102, 1992.
168. KANAI, Y., R. TAKEMURA, T. OSHIMA, H. MORI, Y. IHARA, M. YANAGISAWA, T. MASAKI, AND N. HIROKAWA. Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA. J. Cell Biol. 109: 1173-1184, 1989.
169. KEATS, R. A., AND R. H. HALL. Tubulin requires an accesory protein for self-assembly into microtubules. Nature Lond. 257: 418-420, 1975.
170. KELLOG, D., C. FIELD, AND B. ALBERTS. Identification of microtubule-associated protein in the centrosome, spindle and kinetochore of the early Drosophila embryo, J. Cell Biol. 109: 2977-2992, 1989.
171. KELLOG, D., M. MORITZ, AND B. ALBERTS. The centrosome and cellular organization. Annu. Rev. Biochem. 63: 639-674, 1994.
172. KERYER, G., Z. LUO, J. C. CAVADORE, J. ERLICHMAN, AND M. BORNENS. Phosphorylation of the regulatory subunit of type IIb cAMP dependent protein kinase by cyclin B/p34 cdc2 kinase impairs its binding to microtubule associated protein 2. Proc. Natl. Acad. Sci. USA 90: 5418-5422, 1993.
173. KINDLER, S., B. SCHWANKE, B. SCHULZ, AND C. C. GARNER. Complete cDNA sequence encoding rat high and low molecular weight MAP2. Nucleic Acids Res. 18: 2822, 1990.
174. KIRSCH, J., AND H. BETZ. Widespread expression of gephyrin, a putative glycine receptor-tubulin linker protein in rat brain. Brain Res. 621: 301-310, 1993.
175. KIRSCH, J., D. LANGOSCH, P. PRIOR, U. Z. LITTTAUER, B. SCHMITT, AND H. BETZ. The 93-kDa glycine receptor-associated protein binds to microtubules. J. Biol. Chem. 266: 22242-22245, 1991.
176. KIRSCHNER, M. W. Microtubule assembly and nucleation. Int. Rev. Cytol. 54: 1-71, 1978.
177. KNOPS, J., K S. KOSIK, G. LEE, J. D. PARDEE, L. COHEN GOULD, AND L. McCONLOGUE. Overexpression of tau in a nonneuronal cell induces long cellular processes. J. Cell Biol. 114: 725-773, 1991.
178. KOSIK, K. S., L. D. ORECHIO, S. BAKALIS, AND R. L. NEVE. Developmentally regulated expression of specific tau sequences. Neuron 2: 1389-1397, 1989.
179. KOSIK, K. S., AND L. McCONLOGUE. Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells. Cell Motil. Cytoskeleton 28: 195-198, 1994.
180. KOTANI, S., E. NISHIDA, H. KUMAGI, AND H. SAKAI. Calmodulin inhibits interaction of actin with MAP2 and tau, two major microtubule associated proteins. J. Biol. Chem. 260: 10779-10783, 1985.
181. KRONIDOU, N. G., AND R. D. SLOBODA Partial cloning of a squid microtubule-associated protein (MAPH1) and the identification of the microtubule binding domain. Eur. J. Biochem. 211: 193-204, 1993.
182. KURIYAMA, R., AND C. SELLITTO. A 225 kDa phosphoprotein associated with the mitotic centrosome in sea urchin eggs. Cell Motil. Cytoskeleton 12: 90-103, 1989.
183. KUSTENOV, S. A., V. I. RODIONOV, E. S. NADEZHINA, D. B. MURPHY, AND V. I. GELFAND. Identification of a 34-kd polypeptide as a light chain of microtubule-associated protein-1 (MAP-1) and its association with a MAP-1 peptide that binds to microtubules. J. Cell Biol. 102: 1060-1066, 1986.
184. KUZNETSOV, S. A., AND V. I. GELFAND. 18 kDa microtubule-associated protein: identification as a new light chain (LC-3) of microtubule-associated protein 1 (MAP1). FEBS Lett. 212: 145-148, 1987.
185. LANGKOPF, A., J. A. HAMMARBACK, R. MULLER, R. B. VALLEE, AND C. C. GARNER. Microtubule-associated proteins 1A and LC2. Two proteins encoded in one messenger RNA. J. Biol. Chem. 267: 16561-16566, 1992.
186. LANGOSCH, D., H. WERNER, AND H. BETZ. The 93 kDa protein Gephyrin and tubulin associated with the inhibitory glycin receptor are phosphorylated by an endogenous protein kinase. FEBS Lett. 298: 113-117, 1992.
187. LARCHER, J. C., D. BOUCHER, I. GINZBURG, F. GROS, AND P. DENOULET. Heterogeneity of tau proteins during mouse brain development and differentiation of cultured neuron. Dev. Biol. 154: 195-204, 1992.
188. LAZARIDES, E. Intermediate filaments: a chemically heterogenous, developmentally regulated class of proteins. Annu. Rev. Biochem. 51: 219-250, 1982.
189. LEE, G. Tau protein, an update on structure and function. Cell Motil. Cytoskeleton 15: 199-203, 1990.
190. LEE, G. Non-motor microtubule-associated proteins. Curr. Opin. Cell Biol. 5: 88-94, 1993.
191. LEE, G., N. COWAN, AND M. KIRSCHNER. The primary structure and heterogeneity of tau protein from mouse brain. Science Wash. DC 239: 285-288, 1988.
192. LEE, G., R. NEVE, AND K. KOSIK. The microtubule binding domain of tau protein. Neuron 2: 1616-1624, 1989.
193. LEE, G., AND S. ROOK. Expression of tau protein in non-neuronal cells: microtubule binding and stabilization. J. Cell Sci. 102: 227-237, 1992.
194. LEE, Y. C., AND J. F. WOLFF. Calmodulin binds to both microtubule-associated protein 2 and Τ proteins. J. Biol. Chem. 259: 1226-1230, 1984.
195. LEES-MILLER, J. P., D. M. HELFMAN, AND T. A. SCHROER. Actinrelated protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. Nature Lond. 359: 244-246, 1992.
196. LEWIS, S. A., W. GU, AND N. J. COWAN. Free intermingling of mammalian β-tubulin isotypes among functionally distinct microtubules. Cell 49: 539-544, 1987.
197. LEWIS, S. A., I. E. IVANOV, G.-H. LEE, AND N. J. COWAN. Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau. Nature Lond. 342: 498-505, 1989.
198. LEWIS, S. A., A. VILLASANTE, P. SHERLINE, AND N. COWAN. Brain specific expression of MAP-2 detected using a cloned cDNA probe. J. Cell Biol. 102: 2098-2105, 1986.
199. LEWIS, S. A., D. WANG, AND N. J. COWAN. Microtubule-associated protein MAP2 shares a microtubule-binding motif with tau protein. Science Wash. DC 242: 936-939, 1988.
200. LINDWALL, G., AND R. D. COLE. The purification of tau protein and the occurrence of two phosphorylation states of tau in brain. J. Biol. Chem. 259: 12241-12245, 1984.
201. LITMAN, P., J. BARG, L. RINDZOONSKI, AND I. GINZBURG. Subcellular localization of tau mRNA in differentiating neuronal cell culture: implications for neuronal polarity. Neuron 10: 627-638, 1993.
202. LITTAUER, U., D. GIVEON, M. THIERAUF, I. GINZBURG, AND H. PONSTINGL. Common and distinct tubulin binding sites for microtubule-associated proteins. Proc. Natl. Acad. Sci. USA 83: 7162-7166, 1986.
203. L'HERNAULT, S. W., AND J. L. ROSENBAUM. Chamydomonas α-tubulin is posttranslationally modified by acetylation on the aminogroup of a lysine. Biochemistry 24: 473-478, 1983.
204. LOPATA, M. A., AND D. W. CLEVELAND. In vivo microtubules are copolymers of avaible β-tubulin isotypes: localization of each of six vertebrate β-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens. J. Cell Biol. 105: 1707-1720, 1987.
205. LOOMIS, P. A., T. H. HOWARD, R. P. CASTLEBURRY, AND L. I. BINDER. Identification of nuclear Τ isoforms in human neuroblastoma cells. Proc. Natl. Acad. Sci. USA 87: 8422-8426, 1990.
206. LUCA, F., G. BLOOM, AND R. B. VALLEE. A monoclonal antibody that cross-reacts with phosphorylated epitopes on two microtubule-associated proteins and two neurofllament polypeptides. Proc. Natl. Acad. Sci. USA 83: 1006-1010, 1986.
207. LUDUENA, R. F., AND D. O. WOODWARD. Isolation and partial characterization of α- and β-tubulin from outer doublets of seaurchin sperm and microtubules of chick embryo brains. Proc. Natl. Acad. Sci. USA 70: 3594-3598, 1973.
208. LYNDERSEN, B. K., AND D. E. PETTIJOHN. Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster cell. Cell 22: 489-499, 1980.
209. MACCIONI, R. B. Molecular Cytology of Microtubules. Reviews on Cell Biology, edited by E. Barbera-Guillem. Leíoa, Spain: Servicio Editorial: Universidad del Pais Vasco, 1986.
210. MACCIONI, R. B., AND W. MELLADO. Characteristics of the in vitro assembly of brain tubulin of Cyprinus carpio. Comp. Biochem. Physiol. B Comp. Biochem. 70: 357-380, 1981.
211. MACCIONI, R. B., AND N. SEEDS. Stoichiometry of GTP hydrolysis and tubulin polymerization. Proc. Natl. Acad. Sci. USA 74: 462-468, 1977.
212. MACCIONI, R. B., AND N. SEEDS. Enhancement of tubulin assembly as monitored by a rapid nitration assay. Arch. Biochem. Biophys. 185: 262-271, 1978.
213. MACCIONI, R. B., AND N. W. SEEDS. Limited proteolysis of tubulin: nucleotide stabilizes an active conformation. Biochemistry 22: 1567-1572, 1983.
214. MACCIONI, R. B., L. SERRANO, J. AVILA, AND J. CANN. Characterization and structural aspects of the enhanced assembling capacity of tubulin after removal of its carboxyl-terminal domain. Eur. J. Biochem. 156: 375-381, 1985.
215. MACCIONI, R. B., L. SERRANO, AND J. AVILA. Structural and functional domains of tubulin. Bioessays 2: 166-169, 1986.
216. MACCIONI, R. B., C. RIVAS, AND J. VERA. Biochemical aspects of the regulation of microtubule assembly. In: The Cytoskeleton in Cell Differentiation and Development, edited by R. B. Maccioni and J. Arechaga. Oxford, UK: IRL, 1987, p. 39-48.
217. MACCIONI, R. B., C. RIVAS, AND J. VERA. Differential interaction of synthetic peptides from carboxyl-terminal regulatory domain on tubulin with microtubule associated proteins (MAPs). EMBO J. 7: 1957-1963, 1988.
218. MACCIONI, R. B., J. VERA, J. DOMINGUEZ, AND J. AVILA. A discrete repeated sequence defines a tubulin binding domain on microtubule-associated protein tau. Arch. Biochem. Biophys. 275: 568-579, 1989.
219. MACCIONI, R. B., J. C. VERA, AND J. C. SLEBE. Arginyl residues involvement in the microtubule assembly. Arch. Biochem. Biophys. 207: 248-255, 1981.
220. MACCIONI, R. B., C. VIAL, D. CROSS, AND M. GONZALEZ. Specific macromolecular interactions that modulate the cytoskeleton organization. In: Progress in Cell Biology, edited by J. Becerra, J. M. Pérez-Figares, and P. Fernández-Llebrez. Málaga, Spain: Servicio Editorial Universidad de Malaga, 1992, p. 153-159.
221. MACKAY, A. M., M. D. ECKLEY, C. CHUE, AND W. EARNSHAW. Molecular analysis of the INCENPs (inner centrosomere proteins): separate domains are required for association with microtubules during interphase and with the central spindle during anaphase. J. Cell Biol. 123: 373-385, 1993.
222. MAEKAWA, T., R. LESLIE, AND R. KURIYAMA. Identification of a minus end-specific microtubule-associated protein located at the mitotic poles in cultured mammalian cells. Eur. J. Cell Biol. 54: 255-267, 1991.
223. MAEKAWA, T., AND R. KURIYAMA. Primary structure and microtubule-interacting domain of the SP-H antigen: a mitotic map located at the spindle pole and characterized as a homologous protein to NuMA. J. Cell Sci. 105: 589-600, 1993.
224. MARGOLIS, R. L., AND L. WILSON. Opposite assembly and disassembly of microtubules at steady state in vitro. Cell 13: 1-8, 1978.
225. MARTINEZ, J., F. SANTIBANEZ, C. VIAL, AND R. B. MACCIONI. The antineoplasic agent estramustine and the derivative estramustine-phosphate inhibit secretion of interleukin-3 in leukemic cells. Possible roles of MAPs. Mol. Cell. Biochem. 117: 165-173, 1992.
226. MASSON, D., AND T. E. KREIS. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. J. Cell Biol. 123: 357-371, 1993.
227. MATUS, A. Microtubule associated proteins: the potential role in determining neuronal morphology. Annu. Rev. Neurosci. 11: 29-44, 1988.
228. MAVILIA, C., D. COUCHIE, M. G. MATTEI, M. P. NIVEZ, AND J. NUNEZ. High and low molecular weight Τ proteins are differentially expressed from a single gene. J. Neurochem. 61: 1073-1081, 1993.
229. McNALLY, F. J., AND R. D. VALE. Identification of katanin, an ATP-ase that severs and disassembles stable microtubules. Cell 75: 419-429, 1993.
230. MELKI, R., M. CARLIER, AND D. PANTALONI. Direct evidence for GTP and GDP-P, intermediates in microtubule assembly. Biochemistry 29: 8921-8932, 1990.
231. MELKI, R., P. KERJAN, J. P. WALLER, M. CARLIER, AND D. PANTALONI. Interaction of microtubule-associated protein with microtubules: yeast lysyl- and valyl-t-RNA synthetases and t218-235 synthetic peptide as model system. Biochemistry 30: 11536-11545, 1991.
232. MICHALIK, L., P. NEUVILLE, M.-T. VANIER, AND J.-F. LAUNAY. Biochemical and immunochemical identification of a microtubule-binding protein from bovine pancreas. Cell Motil. Cytoskeleton 25: 381-390, 1993.
233. MIGHELI, A., M. BUTLER, K. BROWN, AND M. M. SHELANSKI. Light and electron microscopic localization of the microtubule-associated tau protein in rat brain. J. Neurosci. 8: 1848-1851, 1988.
234. MITCHISON, T. Compare and contrast actin filaments and microtu-bules. Mol. Biol. Cell 3: 1309-1315, 1992.
235. MITCHISON, T., AND M. W. KIRSCHNER. Microtubule assembly nucleated by isolated centrosomes. Nature Lond. 312: 232-237, 1984.
236. MITCHISON, T., AND M. W. KIRSCHNER. Dynamic instability of microtubule growth. Nature Lond. 312: 237-242, 1984.
237. MITHIEUX, G., AND B. ROUSSET. Identification of a lysosome protein which could mediate ATP-dependent stable association of lysosomes with microtubules. J. Biol. Chem. 264: 4664-4668, 1989.
238. MORAGA, D., P. NUNEZ, J. GARRIDO, AND R. B. MACCIONI. A Τ fragment containing a repetitive sequence induces bundling of actin filaments. J. Neurochem. 61: 979-986, 1993.
239. MORAGA, D., A. RIVAS-BERRIOS, G. FARIAS, M. WALLIN, AND R. B. MACCIONI. Estramustine-phosphate binds to a tubulin binding domain on microtubule associated proteins MAP-2 and tau. Biochim. Biophys. Acta 1121: 97-103, 1992.
240. MOUDJOU, M., M. PAINTRAND, B. VIGUES, AND M. BORNENS. A human centrosomal protein is immunologically related to basal body-associated proteins from lower eukaryotes and is involved in the nucleation of microtubules. J. Cell Biol. 115: 129-140, 1991.
241. MURPHY, D. B., AND G. G. BORISY. Association of high molecular weight proteins with microtubules and their role in microtubule assembly in vitro. Proc. Natl. Acad. Sci. USA 72: 2696-2700, 1975.
242. MURPHY, D. B., K. JOHNSON, AND G. G. BORISY. Role of tubulin associated proteins in microtubule nucleation and elongation. J. Mol. Biol. 117: 33-52, 1977.
243. MURTHY, A. S., G. T. BRAMBLETT, AND N. FLAVIN. The site at which brain microtubule associated protein 2 is phosphorylated in vivo differs from those accessible to cAMP dependent kinase in vitro. J. Biol. Chem. 260: 4364-4370, 1985.
244. NAAS, E., K. ZILLES, H. GNAHN, H. BETZ, C.-M. BECKER, AND H. SCHROEDE. Glycine receptor immunoreactivity in rat and human cerebral cortex. Brain Res. 561: 139-146, 1991.
245. NEVE, R. L., P. HARRIS, K. S. KOSIK, D. M. KURNIT, AND T. A. DONLON. Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Mol. Brain Res. 1: 271-280, 1986.
246. NOBLE, M., S. A. LEWIS, AND J. COWAN. The microtubule binding domain of microtubule-associated protein MAP-1B contains a repeated sequence motif unrelated to that of MAP-2 and tau. J. Cell Biol. 109: 3367-3376, 1989.
247. NUNEZ, J. Immature and mature variants of MAP-2 and tau proteins and neuronal plasticity. Trends Neurosci. 11: 477-479, 1988.
248. OLMSTED, J. B. Microtubule-associated proteins. Annu. Rev. Cell Biol. 2: 421-458, 1986.
249. 2 fragment based on NMR. Biopolymers 31: 449-458, 1991.
250. PADILLA, R., R. B. MACCIONI, AND J. AVILA. Calmodulin binds to a tubulin binding site on the microtubule-associated protein tau. Mol. Cell. Biochem. 97: 35-41, 1990.
251. PALLAS, D., AND F. SOLOMON. Cytoplasmic microtubule-associated proteins: phosphorylation at novel sites is correlated with their incorporation into assembled microtubules. Cell 30: 407-414, 1982.
252. PAPANDRIKOPOULOU, A., T. DOLL, R. TUCKER, C. GARDNER, AND A. MATUS. Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP-2. Nature Lond. 430: 650-652, 1989.
253. PAPASOZOMENOS, S. C., AND L. L. BINDER. Microtubule-associated protein 2 (MAP2) is present in astrocytes of the optic nerve but is absent from astrocytes of the optic tract. J. Neurosci. 6: 1748-1756, 1986.
254. 150GLUEDand a novel actin J. Biol. Chem. 268: 15318-15323, 1993.
255. PASCHAL, B. M., R. A. OBAR, AND R. B. VALLEE. Interaction of brain cytoplasmic dynein and MAP-2 with common sequences at the C-terminus of tubulin. Nature Lond. 342: 569-572, 1989.
256. PATTERSON, C. L., AND M. FLAVIN. A brain phosphatase with specificity for microtubule-associated protein-2. J. Biol. Chem. 261: 7791-7796, 1986.
257. PATURLE-LAFANECHERE, L., B. EDDE, P. DENOULET, A. VAN DOSSELAER, H. MAZARGUIL, J. P. LE ACER, J. WEHLAND, AND D. JOB. Characterization of a major brain tubulin variant which cannot be tyrosinated. Biochemistry 30: 10523-10528, 1991.
258. PEREIRA, A., J. DOSHEN, E. TANAKA, AND L. GOLDSTEIN. Genetic analysis of a Drosophila microtubule-associated protein. J. Cell Biol. 116: 377-383, 1992.
259. PIERRE, P., R. PEPPERKOK, AND T. E. KREIS. Molecular characterization of two functional domains of CLIP-170 in vivo. J. Cell Sci. 107: 1909-1920, 1994.
260. PIERRE, P., J. SCHEEL, J. E. RICKARD, AND T. E. KREIS. Clip-170 links endocytic vesicles to microtubules. Cell 70: 887-900, 1992.
261. PILLUS, L., AND F. SOLOMON. Components of microtubular structures in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 83: 2468-2472, 1986.
262. POLLARD, T., C. SELDEN, AND P. MAUPIN. Interactions of actin filaments with microtubules. J. Cell Biol. 99, Suppl.: 33s-37s, 1984.
263. PORTER, K. R. The cytomatrix: a short history of its study. J. Cell Biol. 99, Suppl: 3s-12s, 1984.
264. PRIOR, P., B. SCHMIT, G. GRENNINGLOH, I. PRIBILLA, G. MULTHAUP, K. BEYREUTHER, Y. MAULET, P. WERNER, D. LANGOSH, J. KIRSCH, AND H. BETZ. Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron 8: 1161-1170, 1992.
265. PRYER, N. K., R. A. WALKER, V. P. SKEEN, B. D. BURNS, M. F. SOPOEIRO, AND E. D. SALMON. Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro. J. Cell Sci. 103: 965-976, 1992.
266. RAFF, J. W., D. R. KELLOG, AND B. M. ALBERTS. Drosophila gamma-tubulin is part of a complex containing previously identified centrosomal MAPs. J. Cell Biol. 121: 823-835, 1993.
267. RAO, P. N., J. ZHAO, R. K. GANJU, AND C. L. ASHORN. Monoclonal antibody against the centrosome. J. Cell Sci. 93: 63-69, 1989.
268. RICKARD, J. E., AND T. E. KREIS. Identification of a novel nucleotide-sensitive microtubule binding protein in HeLa cells. J. Cell Biol. 110: 1623-1633, 1991.
269. RICKARD, J. E., AND T. E. KREIS. Binding of pp170 to microtubules is regulated by phosphorylation. J. Biol Chem. 266: 17597-17605, 1991.
270. RIVAS, C., J. C. VERA, AND R. B. MACCIONI, Anti-idiotypic antibodies reacting with MAPs in the sera of rabbits immunized with synthetic peptides from tubulin regulatory domain. Proc. Natl Acad. Sci. USA 85: 6092-6096, 1988.
271. RIVAS-BERRIOS, A., M. A. HERNANDEZ, J. DOMINGUEZ, J. AVILA, AND R. B. MACCIONI. Common antigenic determinants of the tubulin binding domains of the microtubule-associated proteins MAP-2 and tau. Biochim. Biophys. Acta 1040: 382-390, 1990.
272. ROSE, M. D., S. BIGGINS, AND L. L. SATTERWHITE. Unravelling the tangled web at the microtubule-organizing center. Curr. Opin. Cell Biol. 5: 105-115, 1993.
273. SALMON, E. D., R. J. LESLIE, W. M. SEXTON, M. L. KARNOW, AND R. F. McINTOSH. Spindle microtubule dynamics in sea urchin embryos: analysis using fluorescein-labeled tubulin and measurements of fluorescence redistribution after laser photobleaching. J. Cell Biol. 99: 2165-2174, 1984.
274. SATILLARO, R. F. Interaction of microtubule-associated protein 2 with actin filaments. Biochemistry 25: 2003-2009, 1986.
275. SATO, C., K. NISHIZAWA, H. NAKAMURA, Y. KOMAGOE, K. SHIMADA, R. UEDA, AND S. SUZUKI. Monoclonal antibody against MAP-1 produces immunofluorescence spots in the nucleus and centrosome of cultured mammalian cells. Cell Struct. Fund 8: 245-254, 1983.
276. SCHEEL, J., AND T. E. KREIS. Motor protein independent binding of endocytic carrier vesicles to microtubules in vitro. J. Biol. Chem. 27: 18141-18148, 1991.
277. SCHELDEN, E., AND P. WADSWORTH. Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific. J. Cell Biol. 120: 935-945, 1993.
278. SCHIFF, P. B., J. FANT, AND S. B. HORWITZ. Promotion of microtubule assembly in vitro by taxol. Nature Lond. 277: 665-667, 1979.
279. SCHLIWA, M. The Cytoskeleton. New York: Springer-Verlag, 1985, p. 5-56.
280. SCHLIWA, M., U. EUTENEUER, J. C. BULINSKY, AND J. G. IZANT. Calcium lability of cytoplasmic microtubules and its modulation by microtubule-associated proteins. Proc. Natl. Acad. Sci. USA 78: 1037-1041, 1981.
281. SCHNEIDER, A., A. HEMPHILL, T. WYLER, AND T. SEEBECK. Large microtubule-associated protein of T. brucei has tandemly repeated, near-identical sequences. Nature Lond. 241: 459-462, 1988.
282. SCHOENFELD, T. A., L. McKARRACHER, R. A. OBAR, AND R. B. VALLEE. MAP1A and MAP1B are structurally related microtubule-associated proteins with distinct developmental patterns in the CNS. J. Neurosci, 9: 1712-1730, 1989.
283. SCHOENFELD, T. A., AND R. A. OBAR. Diverse distribution and functions of fibrous microtubule-associated proteins in the nervous system. Int. Rev. Cytol. 151: 67-137, 1994.
284. SCHROER, T. A., AND M. P. SHEETZ. Two activators of microtubule-based vesicle transport. J. Cell Biol 115: 1309-1318, 1991.
285. SCHULZE, E., D. ASAI, J. C. BULINSKI, AND M. W. KIRSCHNER. Posttranslational modification and microtubule stability. J. Cell Biol. 105: 2167-2177, 1987.
286. SEEDS, N. W., AND R. B. MACCIONI. Proteins from morphologically differentiated neuroblastoma cells promote tubulin polymerization. J. Cell Biol. 78: 547-555, 1978.
287. SELDEN, S. C., AND T. D. POLLARD. Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments. J. Biol. Chem. 258: 7064-7071, 1983.
288. SERRANO, L., J. AVILA, AND R. B. MACCIONI. Controlled proteolysis of tubulin by subtilisin. Localization of the site for MAP 2 interaction. Biochemistry 23: 4675-4681, 1984.
289. SERRANO, L., J. DE LA TORRE, R. B. MACCIONI, AND J. AVILA. Involvement of the carboxy-terminal domain of tubulin in microtubule assembly and regulation. Proc. Natl. Acad. Sci. USA 81: 5989-5993, 1984.
290. SERRANO, L., A. VALENCIA, R. CABALLERO, AND J. AVILA. Localization of the high affinity calcium-binding site on the tubulin molecule. J. Biol. Chem. 261: 7076-7081, 1986.
291. SHELANSKI, M. L., F. GASKIN, AND C. R. CANTOR. Assembly of microtubules in the absence of added nucleotides. Proc. Natl. Acad. Sci. USA 70: 765-768, 1973.
292. SHIINA, N., T. MORIGUCHI, K. OHTA, Y. GOTOH, AND E. NISHIDA. Regulation of a major microtubule-associated protein by MPF and MAP kinase. EMBO J. 11: 3977-3984, 1992.
293. SHIOMURA, Y., AND N. HIROKAWA. Colocalization of MAP-1 and MAP-2 on the neuronal microtubules revealed by double labelling immunoelectron microscopy. J. Cell Biol. 104: 1575-1578, 1987.
294. SHPETNER, H. S., AND R. B. VALLEE. Identification of dynamin, a novel mechanochemical enzyme that mediates interactions between microtubules. Cell 59: 421-432, 1989.
295. SLOBODA, R. D., W. L. DENTLER, R. A. BLOODGOOD, B. R. TEIZER, S. GRANETTE, AND J. L. ROSENBAUM. Microtubule-associated proteins (MAPs) and the assembly of microtubules in vitro. In: Cell Motility, edited by R. Goldman, T. Pollard, and J. L. Rosenbaum. Cold Spring Harbor, NY: Cold Spring Harbor, 1976, p. 1171-1212.
296. SLOBODA, R. D., W. L. DENTLER, AND J. L. ROSENBAUM. Microtubule-associated proteins and the stimulation of tubulin assembly in vitro. Biochemistry 15: 4497-4505, 1976.
297. SOBUE, K., M. FUJITA, Y. MURAMOTO, AND S. KAKICHI. The calmodulin-binding protein in microtubules is tau factor. FEBS Lett. 132: 137-140, 1981.
298. SOIFER, D. Factors regulating the presence of microtubules in cells. In: Dynamic Aspects of Microtubule Biology, edited by D. Soider. New York: NY Acad. Sci., 1986, p. 1-7.
299. SOLOMON, F., M. MAGENDANTZ, AND A. SALZMAN. Identification with cellular microtubules of one of the co-assembling microtubule associated proteins. Cell 18: 431-438, 1979.
300. 2+-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. EMBO J. 9: 3539-3544, 1990.
301. SUPRENANT, K. A, K. DEAN, J. McKEE, AND S. HAKE. EMAP, an echinoderm microtubule-associated protein found in microtubuleribosome complexes. J. Cell Sci. 104: 445-456, 1993.
302. SWAROOP, A., M. SWAROOP, AND A. GAREN. Sequence analysis of the complete cDNA and encoded polypeptide for the Glued gene of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 84: 6501-6505, 1987.
303. TAKEMURA, R., S. OKABE, T. UMEYAMA, Y. KANAI, N. J. COWAN, AND N. HIROKAWA. Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP-1B, MAP2 and tau. J. Cell Sci. 103: 953-964, 1992.
304. TALEGHANY, N., AND M. M. OBLINGER. Regional distribution and biochemical characteristics of high molecular weight tau in the nervous system. J. Neurosci. Res. 33: 257-265, 1992.
305. TANG, T. K, C.-J. C. TANG, Y.-J. CHAO, AND C.-W. WU. Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various NuMA isoforms. J. Cell Sci. 107: 1389-1402, 1994.
306. TANG, T. K., C.-J. C. TANG, Y.-L. CHEN, AND C.-W. WU. Nuclear proteins from the bovine esophageal epithelium. II. The NuMA gene gives rise to multiple mRNAs and gene products reactive with monoclonal antibody W1. J. Cell Sci. 104: 249-260, 1993.
307. THERIOT, J. A., AND T. J. MITCHISON. The nucleation-release model of actin filament dynamics in cell motility. Trends Cell Biol. 2: 219-221, 1992.
308. THEURKAUF, W. E., AND R. B. VALLEE. Extensive cAMP-dependent and cAMP-independent phosphorylations of microtubule-associated protein 2. J. Biol. Chem. 258: 7883-7886, 1983.
309. TOUSSON, A., C. ZENG, B. BRINLEY, AND M. M. VALDIVIA. Centrophilin: a novel mitotic spindle protein involved in microtubule nucleation. J. Cell Biol. 112: 427-440, 1991.
310. TRILLER, A., F. CLUZEAUD, F. PFEIFFER, H. BETZ, AND H. KORN. Distribution of glycine receptors at central synapses: an immunoelectron microscopy study. J. Cell Biol. 101: 683-688, 1985.
311. TRUEHEART, J., J. D. BOEKE, AND G. R. FINK. Two genes required for cell fusion during yeast conjugation: evidence for a pheromoneinduced surface protein. Mol. Cell. Biol. 1: 2316-2328, 1987.
312. TSUYAMA, S., G. T. BRAMBLETT, K. P. HUANG, AND M. FLAVIN. Calcium/phospholipid-dependent kinase recognizes sites in microtubule-associated protein 2 which are phosphorylated in living brain and are not accessible to other kinases. J. Biol. Chem. 261: 4110-4116, 1988.
313. TSUYAMA, S., Y. TERAYAMA, AND S. MATSUYAMA. Numerous phosphates of microtubule-associated protein MAP-2 in living rat brain. J. Biol. Chem. 262: 10886-10892, 1987.
314. TUCKER, R. P., AND A. I. MATUS. Developmental regulation of two microtubule-associated proteins (MAP2 and MAP5) in the embryonic avian retina. Development 101: 535-546, 1987.
315. VALDIVIA, M. M., J. AVILA, J. COLL, C. COLACO, AND I. SANDOVAL. Quantitation and characterization of the microtubule-associated MAP 2 in porcine tissues and its isolation from porcine PK15 and human (HeLa) cell lines. Biochem. Biophys. Res. Commun. 105: 1241-1249, 1982.
316. VALE, R. D. Intracellular transport using microtubule-based motors. Annu. Rev. Cell Biol. 3: 347-378, 1987.
317. VALE, R. D., AND L. S. B. GOLDSTEIN. One motor, many tails: an expanding repertoire of force-generating enzymes. Cell 60: 883-885, 1990.
318. VALLANO, M. L., J. R. GOLDENRING, R. S. LASHER, AND R. J. DELORENZO. Association of calcium/calmodulin-dependent kinase with cytoskeleton: phosphorylation of tubulin, neurofilament, and microtubule-associated proteins. In: Dynamic Aspects of Microtubule Biology, edited by D. Soifer. New York: NY Acad. Sci., 1986, p. 357-374.
319. VALLEE, R. B. Structure and phosphorylation of microtubule-associated protein 2 (MAP-2). Proc. Natl. Acad. Sci. USA 77: 3206-3210, 1980.
320. VALLEE, R. B. A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs). J. Cell Biol. 92: 435-442, 1982.
321. VALLEE, R. B. On the use of heat stability as a criterion for the identification of microtubule associated proteins (MAPs). Biochem. Biophys. Res. Commun. 133: 128-133, 1985.
322. VALLEE, R. B. Dynamim: motor protein or regulatory GTPase. J. Muscle Res. Cell Motil. 14: 493-496, 1992.
323. VALLEE, R. B., AND G. S. BLOOM. Isolation of sea urchin egg microtubules with taxol and identification of mitotic spindle microtubule-associated proteins with monoclonal antibodies. Proc. Natl. Acad. Sci. USA 80: 6259-6263, 1983.
324. VALLEE, R. B., AND S. E. DAVIS. Low molecular weight microtubule-associated proteins are light chains of microtubule-associated protein 1 (MAP1). Proc. Natl. Acad. Sci. USA 80: 1342-1346, 1983.
325. VANDRE, D. D., V. E. CENTONZE, J. PELOQUIN, R. M. TOMBES, AND G. G. BORISY. Proteins of the mammalian mitotic spindle: phosphorylation/dephosphorylation of MAP-4 during mitosis. J. Cell Sci. 98: 577-588, 1991.
326. VANTARD, M., P. SCHELLENBAUM, A. FELLOUS, AND A. LAMBERT. Characterization of maize microtubule-associated proteins, one of which is immunologically related to Tau. Biochemistry 30: 9334-9340, 1991.
327. VERA, J. C., C. RIVAS, AND R. B. MACCIONI. Antibodies to synthetic peptides from the tubulin regulatory domain interact with tubulin and microtubules. Proc. Natl. Acad. Sci. USA 85: 6763-6767, 1988.
328. VERA, J. C., C. RIVAS, AND R. B. MACCIONI. Biochemical dissection of the role of the 1 kDa C-terminal domain of tubulin subunits in the assembly of microtubules. Biochemistry 28: 333-339, 1989.
329. VERA, J. C., C. RIVAS, AND R. B. MACCIONI. Heat stable microtubule protein MAP-1 binds to microtubules and induces microtubule assembly. FEBS Lett. 232: 159-162, 1988.
330. VIAL, C., R. ARMAS-PORTELA, J. AVILA, M. GONZALEZ, AND R. B. MACCIONI. A 205 kDa protein from non-neuronal cells in culture contains tubulin binding epitopes. Mol. Cell Biochem. 144: 109-116, 1995.
331. WALKER, R. A., AND M. P. SHEETZ. Cytoplasmic microtubule-associated motors. Annu. Rev. Biochem. 62: 429-451, 1993.
332. WALLIS, K, S. AZHAR, M. RHO, S. LEWIS, N. COWAN, AND D. B. MURPHY. The mechanism of equilibrium binding of microtubule-associated protein 2 to microtubules. J. Biol. Chem. 268: 15158-15167, 1993.
333. WANG, Y., P. LOOMIS, R. ZINKOWSKI, AND L. I. BINDER. A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau. J. Cell Biol. 121: 256-267, 1993.
334. 150Glued-centractin complex reveals a microtubule-binding function in vivo and in vitro (Abstract). Mol. Biol. Cell. 4: 162a, 1993.
335. WEISENBERG, R. C. Microtubule formation in vitro in solutions containing low calcium concentrations. Science Wash. DC 177: 1104-1105, 1972.
336. WEINGARTEN, M., A. LOCKWOOD, S. HWO, AND M. KIRSCHNER. A protein factor essential for microtubule assembly. Proc. Natl. Acad. Sci. USA 72: 1858-1862, 1975.
337. WEINGARTEN, M., M. M. SUTER, D. R. LITTMAN, AND M. W. KIRSCHNER. Properties of the depolymerization products of microtubules from mammalian brain. Biochemistry 13: 5529-5536, 1974.
338. WELSH, M. J., J. R. DEDMAN, B. R. BRINKLEY, AND A. R. MEANS. Calcium dependent regulator protein: localization in the mitotic apparatus of eukaryotic cells. Proc. Natl. Acad. Sci. USA 75: 1867-1871, 1978.
339. WEST, R. R., K. M. TENBARGE, AND J. B. OLMSTED. A model for microtubule-associated protein 4 structure. J. Biol. Chem. 266: 21886-21896, 1991.
340. WHITFIELD, W. G. F., S. E. MILLAR, H. SAUMWEBER, M. FRASCH, AND D. M. GLOVER. Cloning of a gene encoding an antigen associated with the centrosome in Drosophila. J. Cell Sci. 89: 467-480, 1988.
341. WICHE, G., C. OBERKANINS, AND A. HIMMLER. Molecular structure and function of microtubule-associated proteins. Int. Rev. Cytol. 124: 217-273, 1991.
342. WILLE, H., G. DREWES, J. BIERNAT, E. M. MANDELKOW, AND E. MANDELKOW. Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro. J. Cell Biol. 118: 573-584, 1992.
343. WILSON, L. Methods in Cell Biology. The Cytoskeleton. Biological Systems and In Vitro Models. New York: Academic, 1982, vol. 25, pt. B.
344. o) is a microtubule associated protein (Abstract). Mol. Biol. Cell. 5: 292a, 1994.
345. 2+/calmodulin-dependent regulation of microtubule formation via phosphorylation of microtubule-associated protein 2, tau factor, and tubulin, and comparison with cyclic AMP-dependent phosphorylation. J. Neurochem. 44: 759-768, 1985.
346. YANG, C. H., E. J. LAMBIE, AND M. SNYDER. NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. J. Cell Biol. 116: 1303-1317, 1992.
347. YEN, T. J., D. A, COMPTON, Q. WISE, R. ZINKOWSKI, B. BRINKLEY, W. EARNSHAW, AND D. W. CLEVELAND. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J. 10: 1245-1254, 1991.
348. YEN, T. J., G. LI, B. T. SCHAAR, I. SZILAK, AND D. W. CLEVELAND. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature Lond. 359: 536-539, 1992.