Immunosuppressive and anti-inflammatory properties of interleukin 10

Annals of Medicine

Volumn 27, Issue 5, 1995, Pages 537-541

  De Vries, Jan E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anti inflammatory effects; IL 10; Immunosuppression; Inflammatory bowel disease; Lethal shock

Indexed keywords

ANTIINFLAMMATORY AGENT; CHEMOKINE; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; STAPHYLOCOCCUS ENTEROTOXIN B;

ACCESSORY CELL; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; AUTOIMMUNITY; CELL FUNCTION; CHRONIC INFLAMMATION; COLITIS; DENDRITIC CELL; ENTERITIS; EOSINOPHIL; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; LANGERHANS CELL; MACROPHAGE; MALE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEPSIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMAL; ANTI-INFLAMMATORY AGENTS; HUMAN; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-10;

EID: 0028845021     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853899509002465     Document Type: Article

References (48)

1. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties
2. Lymphokine production by human T cells in disease states
3. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
4. + T cell clones and peripheral blood T cells
5. Interleukin 10 (IL-10) and viral IL-10 strongly reduced antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class major histocompatibility complex expression
6. Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10
7. Identification and induction of keratinocytes-derived IL-10
8. Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10
9. Human B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10
10. Interleukin 10
11. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI
12. Interleukin-10
13. Interleukin-10 and its receptor
14. The B7 and CD28 receptor families
15. B70 antigen is a second ligand for CTLA-4 and CD28
16. Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells
17. Low affinity interaction of peptide-MHC complexes with T cell receptors
18. Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary lymphocyte cultures
19. Interleukin-10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells
20. Interleukin-10 inhibits T-cell alloreaction induced by human dendritic cells
21. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression
22. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes
23. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells
24. Regulation of human monocyte functions by interleukin-10
25. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells
26. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
27. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: Comparison to IL-4 and modulation by IFN-y or IL-10
28. Interleukin-8 and related chemotactic cytokines — CXC and CC chemokines
29. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide
30. Regulation of neutrophil-derived chemokine expression by IL-10
31. Interleukin-10 inhibits interleukin-8 production in human neutrophils
32. Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokines production by human peripheral blood eosinophils
33. The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils
34. Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation
35. Interferon y inhibits interleukin 10 production by monocytes
36. Interleukin 10 protects mice from lethal endotoxemia
37. Interleukin 10 reduces the release of tumour necrosis factor and prevents lethality in experimental endotoxemia
38. Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock
39. Superantigens: biology, immunology and potential role in disease
40. T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumour necrosis factor
41. IL-10 acts on the antigen presenting cell to inhibit cytokine production by Th1 cells
42. Interleukin-10-deficient mice develop chronic enterocolitis
43. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
44. + T cells
45. A phase I study of interleukin-10 in healthy humans: safety and effects on cytokine production
46. IL-10 is a potent growth and differentiation factor for activated human B lymphocytes
47. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse
48. High levels of IL-10 production in vivo are associated with tolerance in a SCID patient transplanted with HLA mismatched hematopoietic stem cells