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0019826665
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Establishment in culture of pluripotential cells from mouse embryos
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(1981)
Nature
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Evans1
Kaufman2
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2
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0001007610
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Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
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(1981)
Proc Natl Acad Sci USA
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Martin1
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0024328536
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Altering the genome by homologous recombination
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(1989)
Science
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Capecchi1
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0025975926
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Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture
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(1991)
Development
, vol.111
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Wiles1
Keller2
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10
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0027980468
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Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents
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of special interest, This study demontrates that the development of skeletal muscle myocytes in culture follows a developmental program similar to that observed in vivo.
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(1994)
Dev Biol
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Rohwedel1
Maltsev2
Bober3
Arnold4
Hescheler5
Wobus6
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11
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0028907753
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Embryonic stem cells express neuronal properties in vitro
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of special interest, This paper shows that cells with neuronal properties develop efficiently in culture from embryoid bodies treated with retinoic acid.
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(1995)
Dev Biol
, vol.168
, pp. 342-357
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Bain1
Kitchens2
Yao3
Huettner4
Gottleib5
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15
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0025597062
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An in vitro globin gene switching model based on differentiated embryonic stem cells
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(1990)
Genes Dev
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Lindenbaum1
Grosveld2
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16
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0025910382
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Early fetal hematopoietic developments from in vitro differentiated embryonic stem cells
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(1991)
New Biol
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Burkert1
Von Ruden2
Wagner3
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0025732077
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Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression
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(1991)
Genes Dev
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Schmitt1
Bruyns2
Snodgrass3
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18
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0026545238
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Establishment and characterization of lymphoid and myeloid mixed-cell populations from mouse late embryoid bodies, ‘embryonic-stem-cell fetuses’
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(1992)
Proc Natl Acad Sci USA
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Chen1
Kosco2
Staerz3
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19
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0026465938
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Differentiation of mouse embryonic stem cells to lympho-hematopoietic lineages in vitro
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(1992)
Dev Immunol
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Chen1
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21
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0027270776
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ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients
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(1993)
Development
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Muller1
Dzierzak2
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22
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0028048369
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Generation of lymphohematopoietic cells from embryonic stem cells in culture
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of special interest, This study describes the use of a novel stromal cell line to support the development of B lymphocytes from ES cells differentiated in culture.
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(1994)
Science
, vol.265
, pp. 1098-1101
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Nakano1
Kodama2
Honjo3
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23
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0028271198
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Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo
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(1994)
Int J Immunol
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Nisitani1
Tsubata2
Honjo3
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25
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0029014217
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Generation of hematopoietic colony forming cells from embryonic stem cells: synergy between a soluble factor from NIH-3T3 cells and hematopoietic growth factors
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(1995)
Blood
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Bigas1
Martin2
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27
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0026593326
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Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development
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(1992)
Development
, vol.114
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Wang1
Clark2
Bautch3
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31
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0028970392
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Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development
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of special interest, In this study, embryonic stem cells undergo differentiation in a serum-free defined medium. Under these conditions, BMP-4 is shown to be a potent inducer of hematopoiesis within embryoid bodies.
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(1995)
Mol Cell Biol
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Johansson1
Wiles2
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32
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0027193954
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Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells
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(1993)
Blood
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McClannahan1
Dalrymple2
Barkett3
Lee4
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0018625422
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Hereditary anemias of the mouse: a review for geneticists
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(1979)
Adv Genet
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Russell1
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0021801002
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Erythroid progenitor cells and stimulating factors during murine embryonic and fetal development
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(1985)
Exp Hematol
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Johnson1
Barker2
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38
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0028233760
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Novel insights into erythroid development revealed through in vitro differentiation of GATA-1-embryonic stem cells
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of outstanding interest, Using in vitro differentiation this study identified the defect in GATA-1 ES cells as a block late in the erythroid lineage. These findings highlight the strength of the in vitro differentiation system when analyzing ES cells containing targeted mutations.
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(1994)
Genes Dev
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Weiss1
Keller2
Orkin3
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39
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0028022916
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An early haematopoietic defect in mice lacking the transcription factor GATA-2
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−/− embryo and embryoid bodies are a significant decrease in the number of primitive erythroid precursors and a complete absence of definitive erythroid precursors.
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(1994)
Nature
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Tsai1
Keller2
Kuo3
Weiss4
Chen5
Rosenblatt6
Alt7
Orkin8
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40
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0028030396
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ES-cells carrying two inactivated myf-5 alleles form skeletal muscle cells: activation of an alternative myf-5-independent differentiation pathway
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(1994)
Dev Biol
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, pp. 24-36
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Braun1
Arnols2
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42
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0028670479
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Hematopoietic development of vav−/− mouse embryonic stem cells
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−/− ES cells can generate erythroid and myeloid cells in vitro as well as in chimeric mice.
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(1994)
Proc Natl Acad Sci USA
, vol.91
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Zhang1
Tsai2
Orkin3
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43
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0028859034
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The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro
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−/− embryonic stem cells in this study demonstrates that this gene is essential for early embryonic development but not for early hematopoiesis.
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(1995)
EMBO J
, vol.14
, pp. 1-11
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Zmuidzinas1
Fischer2
Llra3
Forrester4
Bryant5
Bernstein6
Barbacid7
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44
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0026691333
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GATA-binding transcription factors in hematopoietic cells
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(1992)
Blood
, vol.80
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Orkin1
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46
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0024433697
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vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
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(1989)
EMBO J
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Katzav1
Martin2
Barbacid3
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48
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0028915948
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Defective signalling through the T-and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
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(1995)
Nature
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Zhang1
Alt2
Davidson3
Orkin4
Swat5
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50
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0029006696
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Failure of blood island formation and vasculogenesis in FLK-1 deficient mice
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of outstanding interest, This study demonstrates that the receptor tyrosine kinase gene flk-1 is essential for both endothelial and hematopoietic development.
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(1995)
Nature
, vol.376
, pp. 62-66
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Shalaby1
Rossant2
Yamaguchi3
Breitman4
Schuh5
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