The antianginal agent ranolazine is a weak inhibitor of the respiratory Complex I, but with greater potency in broken or uncoupled than in coupled mitochondria

Biochemical Pharmacology

Volumn 50, Issue 10, 1995, Pages 1599-1606

  Wyatt, Katrina M ^a   Skene, Caroline ^a   Veitch, Keith ^b   Hue, Louis ^b   McCormack, James G ^a  

^a HERIOT WATT UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

Author keywords

amytal; mitochondria; NADH dehydrogenase; ranolazine; respiratory Complex I; rotenone

Indexed keywords

AMOBARBITAL; ANTIANGINA PECTORIS AGENT; FERRICYANIDE; MENADIONE; METABOLIC INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; RADIOLIGAND; RANOLAZINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; ROTENONE; SUCCINIC ACID; UBIQUINONE 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GUINEA PIG; HEART MITOCHONDRION; HUMAN; HUMAN TISSUE; LIVER; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SWINE;

ANIMAL; CARBON RADIOISOTOPES; COMPARATIVE STUDY; ELECTRON TRANSPORT; ENZYME INHIBITORS; GUINEA PIGS; HUMAN; MALE; MITOCHONDRIA, HEART; MITOCHONDRIA, LIVER; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; SWINE; TRITIUM;

EID: 0028841015     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02042-X     Document Type: Article

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