Degradation of CFTR by the ubiquitin-proteasome pathway

Cell

Volumn 83, Issue 1, 1995, Pages 121-127

  Ward, Cristina L ^a   Omura, Satoshi ^b   Kopito, Ron R ^a  

^a STANFORD UNIVERSITY   (United States)

^b KITASATO INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEASOME; UBIQUITIN;

ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; ENDOPLASMIC RETICULUM; GENE MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PROCESSING; TEMPERATURE SENSITIVE MUTANT;

EID: 0028840915     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90240-6     Document Type: Article

References (31)

1. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
2. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
3. The ubiquitin-proteasome proteolytic pathway
4. Altered chloride ion channel kinetics associated with the †F508 cystic fibrosis mutation
5. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
6. Chloride conductance expressed by ΔF508 and other mutant CFTRs in Xenopus oocytes
7. Inhibition of proteasome activities and subunitspecific amino-terminal threonine modification by lactacystin
8. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant
9. The endoplasmic reticulum as a site of protein degradation
10. Proteolysis, proteasomes and antigen presentation
11. Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland
12. Identifications of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene
13. Protein degradation in the endoplasmic reticulum
14. A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitinactivating enzyme, E1
15. A general method for rapid site-directed mutagenesis using the polymerase chain reaction
16. Functional differences among nonerythroid anion exchangers expressed in a transfected human cell line
17. Crystal structure of the 20S proteasome from the archaeon T. acidophitum at 3.4 Å resolution
18. Conformational maturation of CFTR but not its mutant counterpart (ΔF508) occurs in the ER and requires ATP
19. Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro
20. Regulation of protein degradation rates in eukaryotes
21. Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells
22. Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator
23. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
24. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
25. The “megaprimer” method of site-directed mutagenesis
26. Translocation of TCR a chains into the lumen of the endoplasmic reticulum and their degradation
27. A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
28. The spectrum of cystic fibrosis mutations
29. Intracellular turnover of cystic fibrosis transmembrane conductance regulator: inefficient processing and rapid degradation of wild-type and mutant proteins
30. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
31. The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment