Design, Synthesis, and Structure-Activity Relationships of a New Series of α-Adrenergic Agonists: Spiro[(1,3-diazacyclopent-1-ene›-5,2′-(1′,2′,3′,4′-tetrahydronaphthalene)]

Journal of Medicinal Chemistry

Volumn 38, Issue 20, 1995, Pages 4056-4069

  Cordi, Alex A ^a   Lacoste, Jean Michel ^a   Descombes, Jean Jacques ^a   Courchay, Christine ^a   Vanhoutte, Paul M ^a   Laubie, Michel ^a   Verbeuren, Tony J ^a  

^a Institut de Recherches Serυier ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 5 TRIFLUOROMETHYLPHENYLIMINO)IMIDAZOLIDINE; 3,4,4A,5,10,10A HEXAHYDRO 6 METHOXY 4 METHYL 9 METHYLTHIO 2H NAPHTH[2,3 B][1,4]OXAZINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; IMIDAZOLINE DERIVATIVE; PRAZOSIN; SPIRO COMPOUND; SPIRO[(1,3 DIAZACYCLOPENT 1 ENE) 5,2' (1',2',3',4' TETRAHYDRONAPHTHALENE)]; TERTATOLOL; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; RAT; SAPHENOUS VEIN; STRUCTURE ACTIVITY RELATION; TEMPERATURE SENSITIVITY; VEIN INSUFFICIENCY;

ADRENERGIC ALPHA-AGONISTS; ANIMAL; DOGS; IMIDAZOLES; IN VITRO; MALE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; VASOCONSTRICTION;

EID: 0028838408     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00020a021     Document Type: Article

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