The genetic toxicology of ethylenethiourea: a case study concerning the evaluation of a chemical's genotoxic potential

Mutation Research/Genetic Toxicology

Volumn 341, Issue 3, 1995, Pages 141-149

  Elia, Michael C ^a,b   Arce, Gail ^a,c   Hurt, Susan S ^a,b   O'Neill, Patricia J ^a,b   Scribner, Harvey E ^a,b  

^a EBDC/ETU Task Force ^*  (United States)

^b ROHM AND HAAS COMPANY   (United States)

^c Department of Regulatory Affairs Elf Atochem North America ^*  (United States)

Author keywords

Ethylenethiourea; Mutagenicity testing; Safety assessment

Indexed keywords

2 IMIDAZOLIDINETHIONE;

ARTICLE; GENOTOXICITY; MUTAGEN TESTING; MUTAGENICITY; MUTATION; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; BACTERIA; CHO CELLS; CHROMOSOME ABERRATIONS; DATABASES, FACTUAL; DNA DAMAGE; DROSOPHILA MELANOGASTER; ETHYLENETHIOUREA; EVALUATION STUDIES; FUNGI; HAMSTERS; MUTAGENICITY TESTS; MUTAGENS;

APOGON BRACHYGRAMMUS; MAMMALIA; RODENTIA;

EID: 0028835623     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1218(95)90004-7     Document Type: Article

References (21)

1. Determination of the genotoxic status of a chemical
2. Overview of study and test chemical activities
3. A method for comparing and combining short-term genotoxicity test data Preface
4. Perspective on the usefulness of the mouse lymphoma assay as an indicator of genotoxic carcinogen - ten compounds which are positive in the mouse lymphoma assay but are not genotoxic carcinogens
5. Comparative carcinogenicity of ethylene thiourea with or without perinatal exposure in rats and mice
6. Ethylene thiourea (ETU) A review of the genetic toxicity studies
7. Evaluation of Short-Term Tests for Carcinogens. Report of the International Collaborative Program
8. Current status of bio-assays in genetic toxicology — the dominant lethal assay. A report of the U.S. Environmental Protection Agency Gene-Tox Program
9. Thyroid follicular cell carcinogenesis
10. A method for comparing and combining short-term genotoxicity test data: the basic system
11. A method for comparing and combining short-term genotoxicity test data: results and interpretation
12. A method for comparing and combining short-term genotoxicity test data: the optimal use of dose information
13. National Toxicology Program, Toxicology and carcinogenesis studies of ethylene thiourea in F344/N rats and B6C3F1 mice (feed studies)
14. Analysis of the cytogenetic activity of ethylenethiourea (ETU) in human peripheral lymphoblast culture in vitro
15. Genotoxicity under extreme conditions
16. Ethylenethiourea (ETU), a carcinogenic and mutagenic metabolite of ethylenebis-dithiocarbamate
17. Genetic risk from chemicals: mutagenicity studies and evalution
18. Evidence for and possible mechanisms of non-genotoxic carcinogenesis in the rodent thyroid