Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

Cell

Volumn 83, Issue 5, 1995, Pages 683-692

  Rexach, Michael ^a   Blobel, Günter ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOPORIN;

ARTICLE; ASSOCIATION; BINDING AFFINITY; DISSOCIATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; STATISTICS;

EID: 0028834428     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90181-7     Document Type: Article

References (38)

1. Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope
2. Cysosolic proteins that specifically bind nuclear location signals are receptors for nuclear import
3. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
4. Genetic and physical interactions between Srpl and nuclear pore complex proteins Nup1p and Nup2p
5. Gsp1 and Gsp2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP binding proteins involved in the maintenance of nuclear organization
6. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1
7. Sequence and characterization of cytoplasmic nuclear import factor p97
8. Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4
9. The NUP1 gene encodes an essential component of the yeast nuclear pore complex
10. Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes
11. Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif
12. Movement of a karyophilic protein through the nuclear pores of oocytes
13. Isolation of a protein that is essential for the first step of nuclear protein import
14. Two different subunits of importin cooperate to recognize nuclear location signals and bind them to the nuclear envelope
15. Distinct functions for the two importin subunits in nuclear protein import
16. Functional interaction of Nic96p with a core nucleoporin complex consisting of Nspl p, Nup49p, and a novel nucleoporin Nup57p
17. A karyophilic protein forms a complex with cytoplasmic components prior to nuclear pore binding
18. In vivo evidence for involvement of a 58 kDa component of nuclear poretargeting complex in nuclear protein import,
19. Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants
20. A short amino acid sequence able to specify nuclear location
21. The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate
22. NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex
23. Inhibition of nuclear protein import by nonhydrolyzable analogs of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor
24. The GTP-binding protein Ran/ TC4 is required for protein import into the nucleus
25. Purification of a Ran-interacting protein that is required for protein import into the nucleus
26. Previously identified protein of uncertain function is karyopherin a and together with karyopherin p docks import substrate at the nuclear pore complex
27. 2β heterodimers: a, or a2 bind nuclear localization signal and p interacts with peptide repeat containing nucleoporins
28. Identification of NTF2, a cytosolic factor for nuclear protein import that interacts with nuclear pore complex protein p62
29. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
30. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins
31. Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores
32. Isolation of the yeast nuclear pore complex
33. Pores for thought: nuclear pore complex proteins
34. + in the cytoplasm
35. Signal recognition particle contains a 7S RNA essential for protein transport across the endoplasmic reticulum
36. Identification of hSRP1a as a functional receptor for nuclear localization sequences
37. NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structure
38. Cloning and characterization of SRP1, a suppressor of temperature-sensitive RNA polymerase I mutations in charomyces cerevisiae