SCOPUS 정보 검색 플랫폼

Volumn 5, Issue 1, 1995, Pages 47-50

Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library

Author keywords

[No Author keywords available]

Indexed keywords

PIPERAZINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS;

EID: 0028833961 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/0960-894X(94)00455-O Document Type: Article

Times cited : (172)

References (16)

3
- 0026419319
- Early publications that describe the use of combinatorial mix and split synthesis include
- (1991) Nature , vol.354 , pp. 84
- Houghten¹ Pinilla² Blondelle³ Appel⁴ Dooley⁵ Cuervo⁶

6
- 0028243847
- For two useful recent surveys of library methods, see:
- (1994) J. Med. Chem. , vol.37 , pp. 1233
- Gallop¹ Barrett² Dower³ Fodor⁴ Gordon⁵

7
- 0028318863
- (two parts)
- (1994) J. Med. Chem. , vol.37 , pp. 1385
- Gallop¹ Barrett² Dower³ Fodor⁴ Gordon⁵

8
- 0027398133
- and subsequent articles in that issue
- (1993) Bioorg. Med. Chem. Lett. , vol.3 , pp. 387
- Pavia¹ Sawyer² Moos³

9
- 0027068161
- For example, (benzodiazepinones)
- (1992) J. Am. Chem. Soc. , vol.114 , pp. 10997
- Bunin¹ Ellman²

14
- 84916569274
- HPLC analytical separation achieved using a reverse phase ES-OVM 4.6mm × 16cm column, eluting 97:3 phosphate buffer (pH6.6): MeCN at 1ml/min. UV detection at 270nM.

16
- 84916569272
- LC/MS analysis. Putative ten-component mixture samples were analysed by capillary LC-MS using a 150 × 0.32mm capillary column containing hypersil ODS 5μm packing, operating at a flow rate of 3 μl/min. Separations were achieved using a water/acetonitrile/trifluoroacetic acid gradient, increasing from 25% to 50% acetonitrile over 30 min. The mobile phase contained 10% glycerol as a matrix for the Continuous Flow Liquid Secondary Ionisation Mass Spectrometry (CF-LSIMS) interface. All of the eluent was transferred directly to the CF-LSIMS interface on a Kratos Concept-1S mass spectrometer scanning from 725 to 150 amu in 3 seconds. Direct MS analysis of the mixtures without prior separation was achieved by chemical ionisation on a VG Trio-3 triple quadrupole instrument using ammonia as the reagent gas. Component structures were confirmed by daughter ion MS/MS using argon as the collision gas.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.